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(±)-カンファー

(±)-カンファー 化学構造式
76-22-2
CAS番号.
76-22-2
化学名:
(±)-カンファー
别名:
(±)-カンファー;カンホル;2-ボルナノン;1,7,7-トリメチルビシクロ[2.2.1]ヘプタン-2-オン;1,7,7-トリメチルノルカンファー;1,7,7-トリメチル-ビシクロ[2.2.1]-ヘプタノン-2;ボルナン-2-オン;しょうのう;2-カンファノン;カンファー;樟脳;シャEノウ;カンフル;(D,L)-ショウ脳;しよう脳;(^+)-カンファー;カンファー, (+/-)-;(^+)-カンファー, 96%;dl-カンフル (JP17);ショウノウ,クロロカンファー
英語化学名:
Camphor
英語别名:
Camphor;camphre;Kampfer;lphanon;Formosa;Caladryl;Radian B;Alphanon;2-CAMPHOR;2-Kamfanon
CBNumber:
CB7159844
化学式:
C10H16O
分子量:
152.23
MOL File:
76-22-2.mol

(±)-カンファー 物理性質

融点 :
175-177 °C(lit.)
沸点 :
204 °C(lit.)
比重(密度) :
0.992
蒸気密度:
5.2 (vs air)
蒸気圧:
4 mm Hg ( 70 °C)
屈折率 :
1.5462 (estimate)
FEMA :
4513 | dl-CAMPHOR
闪点 :
148 °F
貯蔵温度 :
Store below +30°C.
溶解性:
Soluble in acetone, ethanol, diethylether, chloroform and acetic acid.
外見 :
neat
光学活性 (optical activity):
[α]20/D +0.15 to -0.15°, c = 10% in ethanol
爆発限界(explosive limit):
0.6-4.5%(V)
水溶解度 :
0.12 g/100 mL (25 ºC)
Merck :
14,1732
JECFA Number:
2199
BRN :
1907611
Henry's Law Constant:
(x 10-5 atm?m3/mol): 3.00 at 20 °C (approximate - calculated from water solubility and vapor pressure)
暴露限界値:
TLV-TWA 12 mg/m3 (2 ppm), STEL 18 mg/m3 (3 ppm) (ACGIH); IDLH 200 mg/m3 (NIOSH). .
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.
InChIKey:
DSSYKIVIOFKYAU-MHPPCMCBSA-N
CAS データベース:
76-22-2(CAS DataBase Reference)
NISTの化学物質情報:
Camphor(76-22-2)
EPAの化学物質情報:
Camphor (76-22-2)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,Xn,Xi
Rフレーズ  11-22-36/37/38-20/21/22
Sフレーズ  16-26-37/39
RIDADR  UN 2717 4.1/PG 3
WGK Germany  1
RTECS 番号 EX1225000
自然発火温度 870 °F
TSCA  Yes
国連危険物分類  4.1
容器等級  III
HSコード  29142910
有毒物質データの 76-22-2(Hazardous Substances Data)
毒性 LD50 orally in mice: 1.3 g/kg (PB293505)
化審法 (4)-308, (4)-601
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H228 可燃性固体 可燃性固体 1
2
危険
警告
P210, P240,P241, P280, P370+P378
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H317 アレルギー性皮膚反応を起こすおそれ 感作性、皮膚 1 警告 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H371 臓器の障害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P264, P270, P309+P311, P405,P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P240 容器を接地すること/アースをとること。
P241 防爆型の電気機器/換気装置/照明機器/...機器を使 用すること。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場所でのみ使用すること。
P272 汚染された作業衣は作業場から出さないこと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

(±)-カンファー 価格 もっと(32)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA10936 (^+)-カンファー, 96%
(^+)-Camphor, 96%
76-22-2 100g ¥4250 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01AFAA10936 (^+)-カンファー, 96%
(^+)-Camphor, 96%
76-22-2 500g ¥7160 2021-03-23 購入
東京化成工業 C0011 (±)-カンファー >95.0%(GC)
(±)-Camphor >95.0%(GC)
76-22-2 25g ¥1600 2021-03-23 購入
東京化成工業 C0011 (±)-カンファー >95.0%(GC)
(±)-Camphor >95.0%(GC)
76-22-2 500g ¥6700 2021-03-23 購入
Sigma-Aldrich Japan W526606 ≥95.5%
(±)-Camphor ≥95.5%
76-22-2 1 kg ¥15000 2021-03-23 購入

(±)-カンファー 化学特性,用途語,生産方法

外観

本品は無色又は白色半透明の結晶,結晶性の粉末又は塊 で,特異な芳香があり,味はわずかに苦く,清涼味がある.
本品はエタノール(95),ジエチルエーテル又は二硫化炭素 に溶けやすく,水に溶けにくい.
本品は室温で徐々に揮散する.

定義

本品は、次の式で表されるケトンであり、クスノキ Cinnamomum camphora の木部から得られるか、又は合成される。

解説

C10H16O(152.24).カンファーまたはカンフルともいう.二環性モノテルペンケトン.クスノキCinnamomum camphoraに含まれている.クスノキの細片を水蒸気蒸留し,留出するショウノウ油を冷却すると粗結晶が析出する.昇華するか再結晶すれば右旋性のd-ショウノウが得られる."d-ショウノウは融点178~179 ℃,沸点209 ℃."0.99."+44°(エタノール).有機溶剤に可溶.昇華性がある.香料,防虫剤に用いられる.LD50 8000 mg/kg(マウス,静注).また,ピネンからカンフェン,イソボルネオールを経てd,l-ショウノウも合成されている.酸化するとショウノウ酸(camphoric acid),カンファン酸(camphanic acid),カンホロン酸(camphoronic acid)などを生じる."ショウノウ酸C10H16O4は融点187 ℃.[α]D+47°.カンファン酸C10H14O4は融点201 ℃.[α]D+9.1°.カンホロン酸C9H14O6は融点156 ℃.[α]D-27°.pKa1 3.53,pKa2 4.98,pKa3 7.43.
森北出版「化学辞典(第2版)

用途

興奮剤、香料、防虫剤、セルロイド、フィルムの可塑剤、塗料ワニス

化粧品の成分用途

変性剤、可塑剤、外用鎮痛剤、香料

効能

鎮痛薬, 抗炎症薬, 鎮痒薬

商品名

dl−カンフル (小堺製薬)

確認試験

本品0.1gをメタノール2mLに溶かし,2,4-ジニト ロフェニルヒドラジン試液1mLを加えた後,水浴上で5分間 加熱するとき,だいだい赤色の沈殿を生じる.

定量法

本品及びdl-カンフル標準品約0.1gずつを精密に量り, それぞれに内標準溶液5mLを正確に加えた後,エタノール (99.5)に溶かして100mLとし,試料溶液及び標準溶液とする. 試料溶液及び標準溶液2μLにつき,次の条件でガスクロマト グラフィーにより試験を行い,内標準物質のピーク 面積に対するdl-カンフルのピーク面積の比Q T及びQ Sを求 める.
dl-カンフル(C10H16O)の量(mg)=MS × Q T/Q S
MS:dl-カンフル標準品の秤取量(mg)
内標準溶液 サリチル酸メチルのエタノール(99.5)溶液(1 →25)
試験条件
検出器:水素炎イオン化検出器
カラム:内径3mm,長さ3mのガラス管に,ガスクロマ トグラフィー用ポリエチレングリコール20Mをシラ ン処理した180~250μmのガスクロマトグラフィー用 ケイソウ土に10%の割合で被覆したものを充てんす る.
カラム温度:160℃付近の一定温度
キャリヤーガス:窒素
流量:dl-カンフルの保持時間が約6分になるように調 整する.
システム適合性
システムの性能:標準溶液2μLにつき,上記の条件で操 作するとき,dl-カンフル,内標準物質の順に流出し, その分離度は7以上である.
システムの再現性:標準溶液2μLにつき,上記の条件で 試験を6回繰り返すとき,内標準物質のピーク面積に 対するdl-カンフルのピーク面積の比の相対標準偏差 は1.0%以下である.

純度試験

(1) 水分 本品1.0gに二硫化炭素10mLを加えて振り混ぜ るとき,液は濁らない.
(2) 塩素化合物 本品を粉末とし,その0.20gを乾燥した 磁製るつぼにとり,過酸化ナトリウム0.4gを加え,バーナー で徐々に加熱して完全に分解する.残留物を温湯20mLに溶 かし,希硝酸12mLを加えて酸性とした後,ネスラー管中に ろ過し,ろ紙を熱湯5mLずつで3回洗い,ろ液及び洗液を合 わせる.冷後,水を加えて50mLとし,硝酸銀試液1mLを加 えてよく振り混ぜ,5分間放置するとき,液の混濁は次の比 較液より濃くない.
比較液:0.01mol/L塩酸0.20mLを用いて同様に操作する. (3) 不揮発性残留物 本品2.0gを水浴上で加熱して昇華し, 更に105℃で3時間乾燥するとき,残留物は1.0mg以下であ る.

貯法

容器 気密容器.

説明

Camphor was recorded in the ancient books of traditional Chinese medicine, such as Pin Hui Jing Yao, Ben Cao Gang Mu, and Sheng Lian Fang. There has been a long history for traditional Chinese medicine to use camphor.

化学的特性

Camphor, C1oH160, also known as d-2-camphanone, Japan camphor, laurel camphor,Formosa camphor,and gumcamphor,is a terpene ketone. It is colourless solid with a characteristic odour that is obtained from the wood and bark of the camphor tree and is soluble in water and alcohol. It has two optically active forms (dextro and levo) and an optically inactive mixture (racemic) of these two forms. Camphor is used in pharmaceuticals,in disinfectants, in explosives,and to harden nitrocellulose plastics.

化学的特性

Camphor is a colorless glassy solid. Penetrating, characteristic odor.

化学的特性

Both optical isomers are found widely in nature, with (+)-camphor being the more abundant. It is, for example, the main component of oils obtained from the camphor tree C. camphora. Camphor is produced by fractional distillation and crystallization of camphor oil or, synthetically, by dehydrogenation of isoborneol over a copper catalyst.
Due to its characteristic penetrating, slightly minty odor, camphor is only used in perfuming industrial products. It is far more important as a plasticizer.

物理的性質

Colorless to white, flammable granules, crystals or waxy semi-solid with a strong, penetrating, fragrant or aromatic odor. Odor threshold concentration is 0.27 ppm (quoted, Amoore and Hautala, 1983).

来歴

The research and development process of camphor has gone through from the natural product extraction to the modern chemical drug synthesis. For a long time, the Chinese extracted camphor mainly from camphor tree (Cinnamomum camphora), root bark of bodinier cinnamon, and Yunnan camphor tree. With the development of chemical industry, human beings started to use chemical synthesis methods to obtain a large amount of camphor. At present, the chemical synthesis process of camphor in China has been well developed. The synthetic camphor is divided into industrial and pharmaceutical grades. The industrial grade camphor has a content of up to 96% or higher, and the pharmaceutical grade camphor with high purity can meet the standard of pharmacopeia.

使用

dl-Camphor is used as a plasticizer for celluloseesters and ethers; in the manufacture ofplastics and cymene; in cosmetics, lacquers,medicine, explosives, and pyrotechnics; andas a moth repellent.

使用

Antipruritic.

使用

camphor (Cinnamomum camphora) is credited with anesthetic, antiinflammatory, antiseptic, astringent, cooling, and refreshing properties, and thought to be slightly stimulating to blood circulation and function. once absorbed by the subcutaneous tissue, it combines in the body with glucoronic acid and is released through the urine. Camphor is effective for oily and acne skin treatment, and has a scent similar to eucalyptus. In high concentrations, it can be an irritant and numb the peripheral sensory nerves. natural camphor is derived from an evergreen tree indigenous to Asia, although now its synthetic substitute is often used.

定義

camphor: A white crystalline cyclicketone, C10H16O; r.d. 0.99; m.p.179°C; b.p. 204°C. It was formerly obtainedfrom the wood of the Formosancamphor tree, but can now besynthesized. The compound has acharacteristic odour associated withits use in mothballs. It is a plasticizerin celluloid.

適応症

Camphor is a ketone which, when applied in 1% to 3% concentration, has mild antipruritic effects through its anesthetic and counterirritant properties. Counterirritants are substances that, by inducing other sensations such as coolness or warmth, ‘‘crowd out’’ the perception of pain or itch. Camphor is used in various OTC topical analgesic products in concentrations as high as 9%.

定義

A ketone occurring naturally in the wood of the cam- phor tree (Cinnamomum camphora).

定義

A naturally- occurring white organic compound with a characteristic penetrating odor. It is a cyclic compound and a ketone, formerly obtained from the wood of the camphor tree but now made synthetically. Camphor is used as a platicizer for celluloid and as an insecticide against clothes moths.

brand name

Anbesol;Cresophene;Dasin;Ddd;Endrine;Makatussin;Mentol sedans sulfamidad;Nasello;Resol;Root bark oil;Spirit of camphor;Tcp;Tetesept;Topic.

世界保健機関(WHO)

Camphor, an aromatic crystalline substance with mild local anaesthetic activity, is available in preparations for both external application and inhalation. The use of such preparations has precipitated convulsions in susceptible infants. This has led several regulatory authorities to require the inclusion of appropriate warnings on labelling.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 3329, 1976 DOI: 10.1021/jo00882a030

一般的な説明

A colorless or white colored crystalline powder with a strong mothball-like odor. About the same density as water. Emits flammable vapors above 150°F. Used to make moth proofings, pharmaceuticals, and flavorings.

空気と水の反応

Highly flammable. Slightly soluble in water.

反応プロフィール

Naphthalene, Camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967 p. 68].

危険性

Evolves flammable and explosive vapors when heated. Eye and upper respiratory tract irri- tant, and anosmia. Questionable carcinogen.

健康ハザード

Vapors of camphor can irritate the eyes, nose,and throat. In humans, such irritation may be felt at >3 ppm concentration. Prolongedexposure can cause headache, dizziness, andloss of sense of smell. Ingestion can causeheadache, nausea, vomiting, and diarrhea,and at high dosages can lead to convulsion,dyspnea, and coma. High dosages can beharmful to gastrointestinal tracts, kidney,and brain.
LD50 value, intraperitoneal (mice): 3000mg/kg.

健康ハザード

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

火災危険

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

薬理学

Camphor is toxic to human. Overdose of camphor can cause irritability, drowsiness, muscle spasms, vomiting, convulsions, epilepsy, and other symptoms. The lethal dose of camphor is 50–500 mg/kg (oral administration). In general, 2 g of camphor can cause serious toxicity, and 4 g of camphor will produce fatal toxicity.
Camphor can cause a cold sensation similar to mint when applied to human skin. In addition, it has a slightly local anesthetic effect. It can act on the gastrointestinal mucosa to produce a certain degree of stimulating effect. An appropriate dose of camphor can make people feel warm and comfortable in the stomach, but high dose of camphor will cause nausea and vomiting reaction. The effect of camphor on the central nervous system is obvious. It can act on the motor area of cerebral cortex and brain stem to produce the epilepsy-like seizures.
It is generally believed that camphor may have some therapeutic effects on patients with acute heart failure or recurrent collapse. A low dose (50 mg) may treat mild heart fatigue and other illnesses. The oxidized camphor metabolite has a more obvious cardiotonic, hypertensive, and respiratory excitement effects.
Camphor can be absorbed by the body after oral administration easily through the mucous, subcutaneous, and muscle. The in vivo metabolism of camphor occurs mainly in the liver. It is firstly oxidized into camphorol and then goes through phase II metabolism to produce glucuronide conjugate with glucuronic acid. Finally, the vast majority of glucuronide conjugate is excreted from the urine.

臨床応用

Camphor is mainly used for the treatment of pruritic skin diseases, fibrous tissue inflammation, neuralgia, and influenza.

安全性プロファイル

A human poison by ingestion and possibly other routes. An experimental poison by inhalation, subcutaneous, and intraperitoneal routes. A local irritant. Ingestion causes nausea, vomiting, dizziness, excitation, and convulsions. Mutation data reported. Used

職業ばく露

Camphor, a natural product, is used as a plasticizer for cellulose esters and ethers; it is used in lacquers and varnishes; and in explosives and pyrotechnics formulations. It is used as a moth repellent and as a medicinal.

Carcinogenicity

Camphor was not teratogenic to rats or rabbits when administered orally during the fetal period of organogenesis at doses up to 1000mg/kg body weight (bw)/day or 681mg/kg bw/day, respectively.9 Signs of maternal toxicity included clonic convulsions, reduced motility, and reduced body weight gain in rats and reduced food consumption and body weight gain in rabbits.

Source

Major component in pine oil (quoted, Verschueren, 1983). Also present in a variety of rosemary shoots (330–3,290 ppm) (Soriano-Cano et al., 1993), anise-scented basil leaves (1,785 ppm) (Brophy et al., 1993), Iberian savory leaves (2,660 ppm) (Arrebola et al., 1994), African blue basil shoots (7,000 ppm), Greek sage (160–5,040 ppm), Montane Mountain mint (3,395–3,880 ppm), yarrow leaves (45–1,780 ppm), and coriander (100–1,300 ppm) (Duke, 1992).

輸送方法

UN2717 Camphor, synthetic, Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN1130 camphor oil, Hazard Class: 3; Labels: 3-Flammable liquid

不和合性

May form explosive mixture with air. Violent, possibly explosive, reaction with strong oxidizers, especially chromic anhydride, potassium permanganate. May accumulate static electrical charges, and may cause ignition of its vapors.

廃棄物の処理

ncineration of a solution in a flammable solven.

(±)-カンファー 上流と下流の製品情報

原材料

準備製品


(±)-カンファー 生産企業

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76-22-2((±)-カンファー)キーワード:


  • 76-22-2
  • CAMPHOR SQUARES SYNTHETIC TECHNICAL
  • CAMPHOR SYNTHETIC FLAKES
  • CAMPHOR SYNTHETIC POWDER
  • CAMPHOR TECH. GRADE
  • 1,7,7-trimethyl-bicyclo(2.2.1)heptan-2-on
  • 1,7,7-trimethylbicyclo[2.2.1]-2-heptanone (camphor)
  • 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-on
  • 1,7,7-trimethyl-norcampho
  • 2-Bornanone
  • 2-Camphanonoe
  • 2-Camphonone
  • 2-Kamfanon
  • 2-Keto-1,7,7-trimethylnorcamphane
  • 2-oxo-bornan
  • 2-oxobornane
  • Bicyclo[2,2,1]heptan-2-one,1,7,7-trimethyl-
  • Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-
  • Camphor Ep5
  • METHYLBENZYLIDENE
  • CHINESENASALOIL
  • 1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone
  • 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one
  • 1,7,7-Trimethylnorcamphor
  • 2-CAMPHOR
  • 2-Camphanone
  • Bornan-2-one
  • Caladryl
  • Camphor
  • Radian B
  • DL-CAMPHOR USP
  • (±)-カンファー
  • カンホル
  • 2-ボルナノン
  • 1,7,7-トリメチルビシクロ[2.2.1]ヘプタン-2-オン
  • 1,7,7-トリメチルノルカンファー
  • 1,7,7-トリメチル-ビシクロ[2.2.1]-ヘプタノン-2
  • ボルナン-2-オン
  • しょうのう
  • 2-カンファノン
  • カンファー
  • 樟脳
  • シャEノウ
  • カンフル
  • (D,L)-ショウ脳
  • しよう脳
  • (^+)-カンファー
  • カンファー, (+/-)-
  • (^+)-カンファー, 96%
  • dl-カンフル (JP17)
  • ショウノウ,クロロカンファー
  • カンファー他 (可塑剤)
  • テルペン
  • 二環式モノテルペン
  • 機能性材料
  • 可塑剤
  • 生化学
  • 非ステロイド系消炎薬
  • 忌避剤
  • 局所消炎薬
  • 収斂薬
  • 鎮痒剤
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