2'-デオキシアデノシン
2'-デオキシアデノシン 物理性質
- 融点 :
- 187-189 °C
- 沸点 :
- 394.4°C (rough estimate)
- 比重(密度) :
- 1.2938 (rough estimate)
- 屈折率 :
- 1.7610 (estimate)
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,2-8°C
- 溶解性:
- DMSO（微量）、メタノール（微量）、水（微量）
- 酸解離定数(Pka):
- pK1:3.8(+1) (25°C,μ=0.1)
- 外見 :
- 粉
- 色:
- 白い
- 水溶解度 :
- 水、苛性ソーダに溶ける。
- 安定性：:
- 吸湿性
- InChI:
- InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
- InChIKey:
- OLXZPDWKRNYJJZ-RRKCRQDMSA-N
- SMILES:
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)C[C@@H]1O
- CAS データベース:
- 958-09-8(CAS DataBase Reference)
- NISTの化学物質情報:
- Deoxyadenosine(958-09-8)
- EPAの化学物質情報:
- Adenosine, 2'-deoxy- (958-09-8)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| RIDADR |
2811 |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番号 |
AU7358600 |
|
|
| F |
10-23 |
|
|
| TSCA |
Yes |
|
|
| 国連危険物分類 |
6.1 |
|
|
| 容器等級 |
Ⅲ |
|
|
| HSコード |
2934999090 |
|
|
| 化審法 |
(5)-6829, (8)-683 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P310 |
飲み込んだ場合：直ちに医師に連絡すること。 |
|
2'-デオキシアデノシン 価格
もっと(1)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
D4137 |
2'-デオキシアデノシン (無水) >98.0%(HPLC)(T)
2'-Deoxyadenosine Anhydrous
>98.0%(HPLC)(T) |
958-09-8 |
5g |
￥16100 |
2024-03-01 |
購入 |
2'-デオキシアデノシン 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
説明
2'-Deoxyadenosine is a natural deoxyribonucleoside, which is a structural fragment of deoxyribonucleic acid DNA. It is a purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose. Like other natural nucleosides, it is involved in the transmission of genetic information in almost all biological cells, affecting protein synthesis and polysaccharide. It plays a very important role in regulating the growth, proliferation, differentiation and inhibition of cells in vivo.
使用
2'-Deoxyadenosine is used in paradoxical stimulation study of human sperm motility. It plays an essential role as sperm motility stimulants used in sperm micro-injection on mouse and human embryo development. It finds an application in some cells as an energy source under energy stress conditions. It is involved in various biological processes to compare the functions of adenosine analogues.
製造方法
2'-deoxyadenosine synthesis: esterification of adenosine, acylation of an acylating agent and an acid binding agent to obtain an acylate; the obtained acylate is then subjected to reduction and purification to obtain 2'-deoxyadenosine. The esterification agent used in the esterification process is dialkyl tin oxide, 2'-O-p-toluenesulfonyladenosine is synthesized from adenosine, and 2'-deoxyadenosine is synthesized from 2'-O-p-toluenesulfonyladenosine glycosides.
定義
ChEBI: 2'-deoxyadenosine is a purine 2'-deoxyribonucleoside having adenine as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside.
生物活性
2'-Deoxyadenosine is a deoxyribonucleoside and an intermediate in the purine nucleotide degradation pathway. It is transported into cells via facilitated diffusion or formed within cells by degradation of S-adenosylhomocysteine or AMP and is removed from cells by purine metabolism or is converted into adenine nucleotides. 2'-Deoxyadenosine has been used in the characterization of DNA conformations and the synthesis of nucleoside analogs as antiviral agents.
Source
2'-Deoxyadenosine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 2'-Deoxyadenosine is a natural product found in Streptomyces jiujiangensis, Fritillaria przewalskii, and other organisms with data available.
2'-デオキシアデノシン 上流と下流の製品情報
原材料
準備製品
2'-デオキシアデノシン 生産企業
Global( 408)Suppliers
2'-デオキシアデノシン スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS)
958-09-8(2'-デオキシアデノシン)キーワード:
- 958-09-8
- (2R,3S,5R)-5-(6-AMINO-PURIN-9-YL)-2-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-OL
- 2'-DEOXYADENOSINE
- 2'-DEOXY-D-ADENOSINE
- 2'-Deoxyadenosineanhydrous
- 2'-dA·H2O
- 2'-Deoxy-a-adenosine
- 2’-deoxy-adenosin
- 9-(2-Deoxy-beta-D-erythro-pentofuranosyl)adenine
- 9H-Purin-6-amine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
- 9H-Purin-6-amine, 9-(2-deoxy-beta-D-ribofuranosyl)-
- Adenine deoxy nucleoside
- Adenine deoxyribonucleoside
- 2''-DEOXYADENOSINE (isolated from DNA)
- adeninedeoxyribonucleoside
- adeninedeoxyribose
- Adenosine, 2'-deoxy-
- Adenyldeoxyriboside
- beta-D-Erythro-Pentofuranoside, adenine-9 2-deoxy-
- beta-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-
- ADENINE DESOXYRIBOSIDE
- DEOXYADENOSINE-2'
- DESOXYADENOSINE
- 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)ADENINE
- 2-Methoxy 2&rsquo
- N6-Benzoyl-8-benzyloxy-2&rsquo
- 3-Deaza-3-methyl-2&rsquo
- -dA CEP
- 2'-Deoxyadenosine(Da)
- N6-(6-Aminohexyl)-2&rsquo
- -deoxyadenosine-13C2,15N
- アデニンデオキシリボース
- アデニンデオキシリボヌクレオシド
- アデニルデオキシリボシド
- 2'-デオキシアデノシン
- 9-(2-デオキシ-β-D-リボフラノシル)-9H-プリン-6-アミン
- 2'-デオキシ-D-アデノシン
- デオキシアデノシン
- 6-アミノ-9-(2-デオキシ-β-D-リボフラノシル)-9H-プリン
- 2-デオキシアデノシン
- 2'-デオキシアデノシン (無水)
- 2′-デオキシ-D-アデノシン
- 2′-デオキシアデノシン