クロロぎ酸イソブチル 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
溶解性
水に不溶 (徐々に分解)。ベンゼン, エーテル, クロロホルムに可溶。アセトンに極めて溶けやすく、水及びエタノールを加えると、徐々に分解する。
用途
重合触媒?医薬?農薬?樹脂改質剤原料
用途
ペプチド合成における混合酸無水物法。
使用上の注意
クロロぎ酸エステルの一般的性質として、極めて加水分解しやすく、発生する二酸化炭素により、容器内圧が非常に高くなる場合があります。冷所に保存し、開栓時は眼鏡など各種保護具を着用し、少しずつゆっくりと開けて下さい。不活性ガス封入
化学的特性
clear liquid
使用
Isobutyl chloroformate is used as a peptide reagent. It is also used in the preparation of phenethyl-carbamic acid isobutyl ester by reaction with phenethylamine.
一般的な説明
A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible.
空気と水の反応
Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water.
反応プロフィール
Isobutyl chloroformate is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
危険性
Flammable. Corrosive.
健康ハザード
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
火災危険
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
職業ばく露
This is a high volume chemical
with production exceeding 1 million pounds annually in the
U.S . No specific use found
輸送方法
UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison
Inhalation Hazard, 8—Corrosive material; 3—Flammable
liquid; Technical Name Required, Potential Inhalation
Hazard (Special Provision 5). PG II. UN3390 Toxic
by inhalation liquid, corrosive, n.o.s. with an LC50
# 1000 mL/m3 and saturated vapor concentration ≥ 10
LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials,
8—Corrosive material, Technical Name Required,
Inhalation Hazard Zone B
純化方法
It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.]
不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, alcohols, ethers, amines.
Forms explosive mixture with air above flash point
(27C). Compounds of the carboxyl group react with all
bases, both inorganic and organic (i.e., amines) releasing
substantial heat, water and a salt that may be harmful.
Incompatible with arsenic compounds (releases hydrogen
cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat,
toxic and possibly flammable gases), thiosulfates and
dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with
moisture in air to produce highly corrosive and toxic
fumes of hydrogen chloride gas
廃棄物の処理
Disposal of unused product
must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate
protective equipment. For proper handling and disposal,
always comply with federal, state, and local regulations.
クロロぎ酸イソブチル 上流と下流の製品情報
原材料
準備製品