4-(ソジオオキシ)安息香酸プロピル 化学特性,用途語,生産方法
定義
本品は、プロピルパラベン(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称：プロピルパラベン
化粧品の成分用途
防腐剤
効能
抗菌性保存剤
化学的特性
White or almost white, hygroscopic, crystalline powder.
使用
Sodium Propylparaben is a preservative. Sodium Propylparaben is also an excipient used in various pharmaceutical formulations.
調製方法
Propylparaben sodium is produced from benzoic acid.
応用例（製薬）
Propylparaben sodium is used as an antimicrobial or antifungal
preservative in oral pharmaceuticals and in many water-based
cosmetics. It is generally used in combination with other paraben
esters.
接触アレルゲン
This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid
and an alcohol. They are largely used as biocides in
cosmetics and toiletries, medicaments, or food. They
have synergistic power with other biocides. Parabens
can induce allergic contact dermatitis, mainly in
chronic dermatitis and wounded skin.
安全性
Propylparaben sodium is used in oral pharmaceuticals and
cosmetics. The pure form is toxic by the IV route and moderately
toxic by ingestion and the IP route. Propylparaben sodium may
cause asthma, rashes, and hyperactivity.
LD50 (mouse, IP): 0.49 g/kg
LD50 (mouse, IV): 0.18 g/kg
LD50 (mouse, oral): 3.7 g/kg
貯蔵
Propylparaben sodium is stable under normal conditions. It
decomposes on heating. Store in a tightly closed container.
不和合性
The activity of propylparaben sodium can be adversely affected by
the presence of other excipients or active ingredients, such as
atropine, essential oils, iron, magnesium trisilicate, talc, polysorbate
80 and other nonionic surfactants, sorbitol, weak alkalis, and
strong acids.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (oral capsules,
tablets, suspensions). Accepted for use as a food additive in Europe.
Included in nonparenteral medicines (oral capsules, mixtures,
orodispersible tablets, solutions and suspensions; cutaneous emulsions)
licensed in the UK.
4-(ソジオオキシ)安息香酸プロピル 上流と下流の製品情報
原材料
準備製品