5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン
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- CAS番号.
- 648450-29-7
- 化学名:
- 5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン
- 别名:
- 5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン;AS-605240;5-[(4-メチル-3,4-ジヒドロ-2H-1,4-ベンゾオキサジン-7-イル)メチレン]チアゾリジン-2,4-ジオン;5-[(4-メチル-3,4-ジヒドロ-2H-1,4-ベンゾオキサジン-7-イル)メチリデン]-1,3-チアゾリジン-2,4-ジオン
- 英語名:
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- 英語别名:
- AS605240;AS-605240, >=98%;AS-605240(AS 605240);PI 3-Kinase Inhibitor (AS605240);PI 3-Kγ Inhibitor AS-605240 AS605240;PI 3-Kinase Inhibitor (AS605240) B-0301;AS-605240, 98%, a specific inhibitor of PI3Kγ;PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem;5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione;5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- CBNumber:
- CB72100624
- 化学式:
- C12H7N3O2S
- 分子量:
- 257.27
- MOL File:
- 648450-29-7.mol
- MSDS File:
- SDS
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5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン 物理性質
- 比重(密度) :
- 1.553±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO:可溶1mg/mL、透明(加温)
- 酸解離定数(Pka):
- 6.02±0.20(Predicted)
- 外見 :
- 粉
- 色:
- 、淡い赤~オレンジ~こげ茶色
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン 価格
もっと(4)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3578 |
AS 605240 |
648450-29-7 |
10mg |
¥41000 |
2021-03-23 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3578 |
AS 605240 |
648450-29-7 |
50mg |
¥184000 |
2021-03-23 |
購入 |
Sigma-Aldrich Japan
|
A0233 |
≥98% (HPLC)
AS605240 ≥98% (HPLC) |
648450-29-7 |
5mg |
¥20500 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
A0233 |
≥98% (HPLC)
AS605240 ≥98% (HPLC) |
648450-29-7 |
25mg |
¥73200 |
2024-03-01 |
購入 |
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン 化学特性,用途語,生産方法
使用
AS605240 has been used:
- as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
- as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
- as a class 1A PI3K inhibitor?to treat CD4+?T cells.
生物活性
Potent and selective inhibitor of PI 3-kinase γ (PI3K γ ) (IC 50 = 8 nM). Displays 30-fold selectivity over PI3K δ and PI3K β and 7.5-fold selectivity over PI3K α . Suppresses the progression of joint inflammation and damage in both lymphocyte-independent and lymphocyte-dependent mouse models of rheumatoid arthritis. Orally active and ATP-competitive.
Biochem/physiol Actions
AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン 上流と下流の製品情報
原材料
準備製品
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン 生産企業
Global( 137)Suppliers
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン スペクトルデータ(1HNMR)
648450-29-7(5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン)キーワード:
- 648450-29-7
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- AS605240
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
- PI 3-Kinase Inhibitor (AS605240) B-0301
- AS-605240, >=98%
- (E)-5-(quinoxalin-6-ylMethylene)thiazolidine-2,4-dione
- 2,4-Thiazolidinedione, 5-(6-quinoxalinylMethylene)-
- AS-605240(AS 605240)
- (Z)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione AS-605240
- AS-605240
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
- AS-605240, 98%, a specific inhibitor of PI3Kγ
- PI 3-Kinase Inhibitor (AS605240)
- AS 605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
- PI 3-Kγ Inhibitor - CAS 648450-29-7 - Calbiochem
- 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione USP/EP/BP
- 5-(Quinoxalin-6-ylmethylene)thiazolidine-2,4-dione
- PI 3-Kγ Inhibitor AS-605240 AS605240
- 5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン
- AS-605240
- 5-[(4-メチル-3,4-ジヒドロ-2H-1,4-ベンゾオキサジン-7-イル)メチレン]チアゾリジン-2,4-ジオン
- 5-[(4-メチル-3,4-ジヒドロ-2H-1,4-ベンゾオキサジン-7-イル)メチリデン]-1,3-チアゾリジン-2,4-ジオン