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ニタゾキサニド

ニタゾキサニド 化学構造式
55981-09-4
CAS番号.
55981-09-4
化学名:
ニタゾキサニド
别名:
ニタゾキサニド;2-(アセチルオキシ)-N-(5-ニトロ-2-チアゾリル)ベンズアミド
英語化学名:
Nitazoxanide
英語别名:
BRN 1225475;nitazoxamide;NITAZOXANIDE;AURORA KA-645;Nitazoxanide API;Nitazoxanide (200 mg);Nitazoxanide(Alinia, Annita);2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide;2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid;2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
CBNumber:
CB7219063
化学式:
C12H9N3O5S
分子量:
307.28
MOL File:
55981-09-4.mol

ニタゾキサニド 物理性質

融点 :
202°C
比重(密度) :
1.629 g/cm3
貯蔵温度 :
-20°C Freezer
酸解離定数(Pka):
6.18±0.50(Predicted)
極大吸収波長 (λmax):
416nm(Phosphate buffer sol.)(lit.)
Merck :
14,6567
CAS データベース:
55981-09-4(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-36/37/38
Sフレーズ  26-36
WGK Germany  3
RTECS 番号 VN7830000
HSコード  2934100000
毒性 LD50 orally in male, female mice: 1350, 1380 mg/kg; in rats: >10 g/kg (Murphy, Friedmann)
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P501 内容物/容器を...に廃棄すること。

ニタゾキサニド 価格 もっと(9)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQA-5538 ニタゾキサニド
Nitazoxanide
55981-09-4 1g ¥3600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TRCN490100 ニタゾキサニド
Nitazoxanide
55981-09-4 10mg ¥12500 2018-12-26 購入
東京化成工業 N1031 ニタゾキサニド >98.0%(HPLC)(T)
Nitazoxanide >98.0%(HPLC)(T)
55981-09-4 200mg ¥5200 2018-12-04 購入
東京化成工業 N1031 ニタゾキサニド >98.0%(HPLC)(T)
Nitazoxanide >98.0%(HPLC)(T)
55981-09-4 1g ¥16800 2018-12-04 購入
Sigma-Aldrich Japan N0290 ニタゾキサニド ≥98% (HPLC)
Nitazoxanide ≥98% (HPLC)
55981-09-4 10mg ¥16200 2018-12-25 購入

ニタゾキサニド 化学特性,用途語,生産方法

効能

抗原虫薬

化学的特性

Crystalline Solid

使用

An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.

使用

antihypertensive

使用

For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia and for the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum.

brand name

Alinia (Romark).

抗菌性

In vitro Cryptosporidium parvum sporocytes and oocysts are inhibited by <33 μm, and Giardia lamblia (intestinalis) trophozoites by <10 μm. The metabolite tizoxanide is more active than the parent compound against some isolates. E. histolytica is inhibited by 6–23 μm (parent compound) and 5.6– 28 μm (metabolite), and T. vaginalis by 0.5–15.5 μm (parent compound) and 0.3–12.2 μm (metabolite). Activity against other micro- organisms, including some helminths, bacteria (Clostridium difficile) and viruses (hepatitis C) has also been demonstrated.

獲得抵抗性

Resistance caused by altered expression of genes involved in stress response has been demonstrated in experimental studies with G. lamblia.

応用例(製薬)

A synthetic broad-spectrum antiparasitic nitroheterocycle (2-acetyloxy- N-(5-nitro-2-thiazolyl) benzamide), formulated for oral use.

薬物動態学

After oral administration the major circulating metabolites are tizoxanide (desacetyl nitazoxanide) and its glucuronide. Minor metabolites include salicyluric acid and tizoxanide sulfate. Maximum concentrations of the active metabolites tizoxanide and tizoxanide glucuronide are observed within 1–4 h. Following a single oral dose of 500 mg given with food, the Cmax of both metabolites was around 10 mg/L. Tizoxanide has a halflife of around 1–2 h and is >99.9% bound to plasma proteins.

臨床応用

It is indicated for the treatment of diarrhea caused by G. lamblia or C. parvum.

副作用

Nitazoxanide appears well tolerated. Side effects may include abdominal pain diarrhea, headache and nausea.

Veterinary Drugs and Treatments

Nitazoxanide oral paste is indicated for the treatment of horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
In humans, nitazoxanide is approved (in the USA) for use in treating diarrhea caused by Cryptosporidium parvum and Giardia lamblia in pediatric patients from ages 1 to 11 years old.
Because of the drug’s spectrum of activity and apparent safety, there is considerable interest in using it in a variety of companion animal species, but data is lacking for specific indications and dosages.

ニタゾキサニド 上流と下流の製品情報

原材料

準備製品


ニタゾキサニド 生産企業

Global( 211)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
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Haihang Industry Co.,Ltd
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Hebei Guanlang Biotechnology Co., Ltd.
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Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

55981-09-4(ニタゾキサニド)キーワード:


  • 55981-09-4
  • n-(5-nitro-2-thiazolyl)-salicylamidacetate(ester)
  • n-(5-nitro-2-thiazolyl)salicylamideacetate(ester)
  • AURORA KA-645
  • o-[n-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate
  • NITAZOXANIDE
  • nitazoxamide
  • PH-5776, Cryptaz, 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
  • 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
  • [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
  • [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] ethanoate
  • acetic acid [2-[(5-nitrothiazol-2-yl)carbamoyl]phenyl] ester
  • Nitazoxanide (200 mg)
  • Nitazoxanide(Alinia, Annita)
  • Nitazoxanide API
  • 2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
  • 2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid
  • BRN 1225475
  • 2-((5-nitrothiazol-2-yl)carbaMoyl)phenyl acetate
  • Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-
  • ニタゾキサニド
  • 2-(アセチルオキシ)-N-(5-ニトロ-2-チアゾリル)ベンズアミド
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