4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン
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- CAS番号.
- 941685-27-4
- 化学名:
- 4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン
- 别名:
- 4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン;4-(1H-ピラゾール-4-イル)-7-[[2-(トリメチルシリル)エトキシ]メチル]-7H-ピロロ[2,3-d]ピリミジン;4-(7-{[2-(トリメチルシリル)エトキシ]メチル}-7H-ピロロ[2,3-d]ピリミジン-4-イル)-1H-ピラゾール
- 英語名:
- 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
- 英語别名:
- INCB032304;CS-1703;RROLO[2,3-D]PYRIMIDINE;-7-((2-(trimethylsilyl);Barretinib Intermediate 1;4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl-7H-p...;4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]p;4-(4-Pyrazolyl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine;(1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine;rimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
- CBNumber:
- CB72467325
- 化学式:
- C15H21N5OSi
- 分子量:
- 315.45
- MOL File:
- 941685-27-4.mol
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4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン 物理性質
- 沸点 :
- 501.8±50.0 °C(Predicted)
- 比重(密度) :
- 1.20±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 酸解離定数(Pka):
- 10.87±0.50(Predicted)
- InChIKey:
- AVMLPTWVYQXRSV-UHFFFAOYSA-N
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
主な危険性 |
Xn |
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Rフレーズ |
22 |
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国連危険物分類 |
IRRITANT |
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絵表示(GHS) |
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注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
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注意書き |
P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン 価格
もっと(16)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS035271 |
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine |
941685-27-4 |
1g |
¥149500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCP847000 |
4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine |
941685-27-4 |
100mg |
¥388500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS035271 |
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine |
941685-27-4 |
5g |
¥402500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBST-0174 |
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7h-pyrrolo[2,3-d]pyrimidine |
941685-27-4 |
1g |
¥16000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBST-0174 |
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7h-pyrrolo[2,3-d]pyrimidine |
941685-27-4 |
5g |
¥47500 |
2024-03-01 |
購入 |
4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン 化学特性,用途語,生産方法
使用
4-(1H-Pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine is an important intermediate in the preparation of the janus kinase inhibitor INCB018424.
合成
To a flask equipped was added 4-chloro-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine and dioxane and then added 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole followed by a solution of potassium carbonate in water. The solution was degassed by passing a stream of nitrogen through the solution for 15 minutes before being treated with tetrakis(triphenylphosphine)palladium(0), and the resulting reaction mixture was heated at reflux (about 90° C) for 2 hours. When the reaction was complete, the mixture was cooled to room temperature and diluted with ethyl acetate and water. The two layers were separated, and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulfate (Na2SO4), and concentrated under reduced pressure. The residue was suspended in toluene, and the solvent was removed under reduced pressure. The residue was finally triturated with methyl tert-butyl ether, and the solid was collected by filtration and washed with MTBE to afford 4-(1H-pyrazol-4-yl)-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine (yield 64%) as white crystalline solids.
4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン 上流と下流の製品情報
原材料
methyl 4-cyano-3-oxobutanoate
ETHYL 4-CYANOACETOACETATE
1-(1-エトキシエチル)-4-(4,4,5,5-テトラメチル-1,3,2-ジオキサボロラン-2-イル)-1H-ピラゾール
4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
2-(クロロメトキシ)エチルトリメチルシラン
4-(4,4,5,5-テトラメチル-1,3,2-ジオキサボロラン-2-イル)ピラゾール
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-[7-[[2-(triMethylsilyl)ethoxy]Methyl]-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-[7-[[2-(triMethylsilyl)ethoxy]Methyl]-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-, (βS)-
6-クロロ-7-デアザプリン
4-クロロ-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン
準備製品
4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン 生産企業
Global( 243)Suppliers
4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン スペクトルデータ(1HNMR)
941685-27-4(4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン)キーワード:
- 941685-27-4
- 4-(1H-PYRAZOL-4-YL)-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE
- trimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
- 4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
- -7-((2-(trimethylsilyl)
- Barretinib Intermediate 1
- CS-1703
- 4-(4-Pyrazolyl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-7H-pyrrolo[2,3-d]pyrimidine
- 4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]p
- 7H-Pyrrolo[2,3-d]pyrimidine, 4-(1H-pyrazol-4-yl)-7-[[2-(trimethylsilyl)ethoxy]methyl]-
- RROLO[2,3-D]PYRIMIDINE
- 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl-7H-p...
- 4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole
- 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidineQ: What is
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Q: What is the CAS Number of
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine Q: What is the storage condition of
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
- INCB032304
- (1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
- rimethyl-[2-[[4-(1H-pyrazol-4-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methoxy]ethyl]silane
- 4- (1H pyrazole-4-yl) -7- (2- (trimethylsilyl) ethoxy) - methyl) -7H pyrrolo [2,3-d] pyrimidine
- 4-(1H-ピラゾール-4-イル)-7-((2-(トリメチルシリル)エトキシ)メチル)-7H-ピロロ[2,3-D]ピリミジン
- 4-(1H-ピラゾール-4-イル)-7-[[2-(トリメチルシリル)エトキシ]メチル]-7H-ピロロ[2,3-d]ピリミジン
- 4-(7-{[2-(トリメチルシリル)エトキシ]メチル}-7H-ピロロ[2,3-d]ピリミジン-4-イル)-1H-ピラゾール