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Pyr3

Pyr3 化学構造式
1160514-60-2
CAS番号.
1160514-60-2
化学名:
Pyr3
别名:
Pyr3;2,3,3-トリクロロ-N-[4-[4-(エトキシカルボニル)-5-(トリフルオロメチル)-1H-ピラゾール-1-イル]フェニル]アクリルアミド;1-[4-(2,3,3-トリクロロプロペノイルアミノ)フェニル]-5-(トリフルオロメチル)-1H-ピラゾール-4-カルボン酸エチル;5-(トリフルオロメチル)-1-[4-[(2,3,3-トリクロロプロペノイル)アミノ]フェニル]-1H-ピラゾール-4-カルボン酸エチル;5-(トリフルオロメチル)-1-[4-[(2,3,3-トリクロロアクリロイル)アミノ]フェニル]-1H-ピラゾール-4-カルボン酸エチル;エチル 1-[4-(2,3,3-トリクロロプロパ-2-エンアミド)フェニル]-5-(トリフルオロメチル)-1H-ピラゾール-4-カルボキシラート
英語名:
1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
英語别名:
Pyr3;Pyr3,Pyr-3;TRPC3 Channel Inhibitor, Pyr3;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester
CBNumber:
CB72518795
化学式:
C16H11Cl3F3N3O3
分子量:
456.63
MOL File:
1160514-60-2.mol

Pyr3 物理性質

融点 :
151-153 °C(Solv: toluene (108-88-3))
沸点 :
534.0±50.0 °C(Predicted)
比重(密度) :
1.54±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO に可溶 (最大 40 mg/ml)。
外見 :
粉
酸解離定数(Pka):
9.97±0.70(Predicted)
色:
白からベージュ
安定性：:
購入日から2年間安定です。この DMSO 溶液は、-20°C で 3 か月間保存できます。

安全性情報

Pyr3 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3751
Pyr3 		1160514-60-2 10mg ￥67000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3751
Pyr3 		1160514-60-2 50mg ￥281000 2024-03-01 購入
Sigma-Aldrich Japan P0032 ≥98% (HPLC)
Pyr3 ≥98% (HPLC)		 1160514-60-2 5mg ￥52500 2024-03-01 購入
Sigma-Aldrich Japan P0032 ≥98% (HPLC)
Pyr3 ≥98% (HPLC)		 1160514-60-2 25mg ￥124000 2024-03-01 購入

Pyr3 化学特性,用途語,生産方法

使用

Pyr3 is a pyrazole derivative that is used to discriminate between (transient receptor potential cation) TRPC4 mediated receptor operated calcium entry and STIM1/Ora1 mediated store operated calcium entry pathway in human embryonic kidney and rat mast cells.

一般的な説明

A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 μM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 μM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies.

Biochem/physiol Actions

Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.

Pyr3 上流と下流の製品情報

原材料

準備製品

Pyr3 生産企業

Global( 51)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 57511 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14059 65
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 3444 55
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049
 3119594100@qq.com China 7765 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
 liming@bio-fount.com China 9730 58

Pyr3  スペクトルデータ(1HNMR)

1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid(1160514-60-2)1HNMR

1160514-60-2(Pyr3)キーワード:

イコサペンタエン酸 KY02111 ドルソモルヒン ベラパミル塩酸塩
  • 1160514-60-2
  • 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
  • Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
  • TRPC3 Channel Inhibitor, Pyr3
  • 1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester
  • TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
  • 1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester
  • Pyr3
  • Pyr3,Pyr-3
  • Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
  • Pyr3
  • 2,3,3-トリクロロ-N-[4-[4-(エトキシカルボニル)-5-(トリフルオロメチル)-1H-ピラゾール-1-イル]フェニル]アクリルアミド
  • 1-[4-(2,3,3-トリクロロプロペノイルアミノ)フェニル]-5-(トリフルオロメチル)-1H-ピラゾール-4-カルボン酸エチル
  • 5-(トリフルオロメチル)-1-[4-[(2,3,3-トリクロロプロペノイル)アミノ]フェニル]-1H-ピラゾール-4-カルボン酸エチル
  • 5-(トリフルオロメチル)-1-[4-[(2,3,3-トリクロロアクリロイル)アミノ]フェニル]-1H-ピラゾール-4-カルボン酸エチル
  • エチル 1-[4-(2,3,3-トリクロロプロパ-2-エンアミド)フェニル]-5-(トリフルオロメチル)-1H-ピラゾール-4-カルボキシラート
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