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ビラゾドン塩酸塩

ビラゾドン塩酸塩 化学構造式
163521-08-2
CAS番号.
163521-08-2
化学名:
ビラゾドン塩酸塩
别名:
ビラゾドン塩酸塩;5-[4-[4-(5-シアノ-1H-インドール-3-イル)ブチル]ピペラジン-1-イル]ベンゾフラン-2-カルボキサミド塩酸塩
英語化学名:
Vilazodone Hydrochloride
英語别名:
CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;Vilazodone hydrochloride;Vera trazodone hydrochloride;Vilazodone hydrochloride API;Vilazodone hydrochloride salt;Vilazodone hydrochloride solution;VILAZODONE; EMD 68843; SB 659746A
CBNumber:
CB72521214
化学式:
C26H28ClN5O2
分子量:
477.98582
MOL File:
163521-08-2.mol

ビラゾドン塩酸塩 物理性質

融点 :
279°C(lit.)
闪点 :
9℃
貯蔵温度 :
Inert atmosphere,Store in freezer, under -20°C
溶解性:
DMSO: soluble20mg/mL, clear
外見 :
powder
色:
white to beige
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  F,T
Rフレーズ  11-23/24/25-39/23/24/25
Sフレーズ  7-16-36/37-45
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
HSコード  29329990
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。

ビラゾドン塩酸塩 価格 もっと(5)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 V0149 ビラゾドン塩酸塩 >98.0%(HPLC)
Vilazodone Hydrochloride >98.0%(HPLC)
163521-08-2 50mg ¥14500 2021-03-23 購入
東京化成工業 V0149 ビラゾドン塩酸塩 >98.0%(HPLC)
Vilazodone Hydrochloride >98.0%(HPLC)
163521-08-2 200mg ¥40600 2021-03-23 購入
Sigma-Aldrich Japan SML1098 ≥98% (HPLC)
Vilazodone hydrochloride ≥98% (HPLC)
163521-08-2 10mg ¥10080 2021-03-23 購入
Sigma-Aldrich Japan SML1098 ≥98% (HPLC)
Vilazodone hydrochloride ≥98% (HPLC)
163521-08-2 50mg ¥49900 2021-03-23 購入
Sigma-Aldrich Japan V-023 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
Vilazodone hydrochloride solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material
163521-08-2 1ml ¥41600 2018-12-25 購入

ビラゾドン塩酸塩 化学特性,用途語,生産方法

外観

白色~うすい黄色粉末~結晶

効能

抗うつ薬, セロトニン受容体拮抗・再取り込み阻害薬

定義

ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.

臨床応用

Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.

Chemical Synthesis

Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.

ビラゾドン塩酸塩 上流と下流の製品情報

原材料

準備製品


ビラゾドン塩酸塩 生産企業

Global( 215)Suppliers
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Shanghai Yingrui Biopharma Co., Ltd.
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163521-08-2(ビラゾドン塩酸塩)キーワード:


  • 163521-08-2
  • 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide hydrochloride
  • Vilazodone hydrochloride
  • 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxaMide hydrochloride、Vilazodone hydrochloride
  • EMD 68843
  • SB 659746A
  • CS-796
  • 5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride
  • VILAZODONE; EMD 68843; SB 659746A
  • Vilazodone hydrochloride solution
  • Vilazodone HCl, >=98%
  • Vilazodone hydrochloride, 98%, a 5-HT1A receptor partial agonist
  • Vera trazodone hydrochloride
  • Vilazodone hydrochloride(Vilazodone HCl)
  • Vilazodone hydrochloride API
  • vilazodone hydrochloride fandachem
  • 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide hydrochloride fandachem
  • 2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1)
  • 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide hydrochloride
  • Vilazodone Hydrochloride USP/EP/BP
  • Vilazodone hydrochloride salt
  • ビラゾドン塩酸塩
  • 5-[4-[4-(5-シアノ-1H-インドール-3-イル)ブチル]ピペラジン-1-イル]ベンゾフラン-2-カルボキサミド塩酸塩
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