AHU-377 (heMicalciuM salt)
AHU-377 (heMicalciuM salt) 物理性質
- 融点 :
- >140°C (dec.)
- 比重(密度) :
- 1.24g/cm3 at 20℃
- 蒸気圧:
- 0.001Pa at 20℃
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO（微量、加熱）、メタノール（微量）
- 外見 :
- 粉
- 色:
- 白からベージュ
- LogP:
- -0.66-2.9 at 20℃ and pH2-7
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| RIDADR |
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
|
|
| 絵表示（GHS） |
 
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
| H400 |
水生生物に強い毒性 |
水生環境有害性、急性毒性 |
1 |
警告 |
|
P273, P391, P501 |
|
| 注意書き |
|
AHU-377 (heMicalciuM salt) 価格
もっと(10)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-5920 |
Ahu-377 hemicalcium salt |
1369773-39-6 |
1g |
￥22000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-5920 |
Ahu-377 hemicalcium salt
Ahu-377 hemicalcium salt |
1369773-39-6 |
5g |
￥77500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-3237 |
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methylpentan-2-yl)amino)-4-oxobutanoic acid |
1369773-39-6 |
100mg |
￥25000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-3237 |
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methylpentan-2-yl)amino)-4-oxobutanoic acid |
1369773-39-6 |
250mg |
￥50000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-3237 |
4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methylpentan-2-yl)amino)-4-oxobutanoic acid |
1369773-39-6 |
1g |
￥130000 |
2024-03-01 |
購入 |
AHU-377 (heMicalciuM salt) 化学特性,用途語,生産方法
使用
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Biochem/physiol Actions
Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.
AHU-377 (heMicalciuM salt) 上流と下流の製品情報
原材料
準備製品
AHU-377 (heMicalciuM salt) 生産企業
Global( 278)Suppliers
1369773-39-6()キーワード:
- 1369773-39-6
- AHU-377 (heMicalciuM salt)
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
- (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)
- AHU-377 hemicalcium salt (2:1)
- Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate)
- Sacubitril Hemicalcium salt
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
- [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
- (alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt
- LCZ696(valsartan + sacubitril) impurity 1
- Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
- (alphar
- 1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
- gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1
- LCZ696-1
- monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate)
- Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt)
- AHU377 Calcium Salt
- AHU-377 Hemicalcium
- LCZ696 Impurity 534-06
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal
- LCZ696 intermediates，AHU-377 (heMicalciuM salt)
- (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m...
- SACUBITRIL-13C4 CALCIUM
- Sacubitril-d5 Calcium Salt
- Sacubitril 13C4 CalciumQ: What is
Sacubitril 13C4 Calcium Q: What is the CAS Number of
Sacubitril 13C4 Calcium
- (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
- Sacubitril Calcium
- Sacubitril calcium salt