N-(2-(2-(2-メトキシ-4-モルホリノフェニルアミノ)-5-フルオロピリミジン-4-イルアミノ)フェニル)メタンスルホンアミド 化学特性,用途語,生産方法
説明
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC
50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2
G2019S, a mutant linked to neurotoxicity and Parkinson’s disease, with an IC
50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell lysates, Jurkat/Ramos mixed cell lysates, as well as whole mouse brain extracts (IC
50s = >2 μM). It reduces LRRK2
G2019S-induced cell injury in rat primary cortical neurons.
使用
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.
N-(2-(2-(2-メトキシ-4-モルホリノフェニルアミノ)-5-フルオロピリミジン-4-イルアミノ)フェニル)メタンスルホンアミド 上流と下流の製品情報
原材料
準備製品