N-(4-フルオロベンジル)-1,1-ジフェニル-3-オキソヘキサヒドロオキサゾロ[3,4-a]ピリジン-7-カルボアミド 化学特性,用途語,生産方法
説明
SHA-68 is an antagonist of the neuropeptide S receptor (NPSR; IC
50s = 22 and 23.8 nM for the NPSR Asn
107 and NPSR Ile
107 isoforms, respectively). It is selective for NPSR over a panel of 14 G protein-coupled receptors exhibiting no activity at a concentration of 10 μM. SHA-68 (50 mg/kg) reduces NPS-induced horizontal activity and vertical rearing and climbing in mice. SHA-68 also reduces conditioned reinstatement of cocaine seeking in rats.
使用
SHA 68 is a selective neuropeptide S antagonist.
N-(4-フルオロベンジル)-1,1-ジフェニル-3-オキソヘキサヒドロオキサゾロ[3,4-a]ピリジン-7-カルボアミド 上流と下流の製品情報
原材料
準備製品