A-1210477
|
|
- CAS番号.
- 1668553-26-1
- 化学名:
- 别名:
- 英語名:
- A-1210477
- 英語别名:
- CS-2151;CS-2202;A-1210477;Abbvie Mcl-1 Inhibitor;A-1210477;A 1210477;A1210477;A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis;7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
- CBNumber:
- CB73040415
- 化学式:
- C46H55N7O7S
- 分子量:
- 850.04
- MOL File:
- 1668553-26-1.mol
|
A-1210477 物理性質
- 沸点 :
- 1027.4±65.0 °C(Predicted)
- 比重(密度) :
- 1.32±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- insoluble in DMSO; insoluble in H2O; insoluble in EtOH
- 外見 :
- Powder
- 酸解離定数(Pka):
- 4.43±0.30(Predicted)
- 色:
- White to off-white
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
A-1210477 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
A-1210477 化学特性,用途語,生産方法
説明
A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; K
i = 0.43 nM and IC
50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (K
is > 0.66 μM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1). It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.
A-1210477 上流と下流の製品情報
原材料
準備製品
A-1210477 生産企業
Global( 79)Suppliers
- 1668553-26-1
- A-1210477
- Abbvie Mcl-1 Inhibitor
- 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid
- 7-(5-((4-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid
- CS-2202
- CS-2151
- A-1210477;A 1210477;A1210477
- 1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-
- A-1210477,inhibit,Inhibitor,A 1210477,Bcl-2 Family,A1210477,Apoptosis