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アデノシン

アデノシン 化学構造式
58-61-7
CAS番号.
58-61-7
化学名:
アデノシン
别名:
アデノシン;β-D-アデノシン;6-アミノ-9-β-D-リボフラノシル-9H-プリン;アデノスキャン;ミオコール;アデニンリボシド;β-アデノシン;アデノシンリボシド;ヌクレオカルジル;リボアデノシン;ボニトン;サンデシン;アデノカード;1-(6-アミノ-9H-プリン-9-イル)-1-デオキシ-β-D-リボフラノース;9-(β-D-リボフラノシル)-9H-プリン-6-アミン;アデノカルド;(-)-アデノシン;アデノシン (JAN)
英語化学名:
Adenosine
英語别名:
AR;Myocol;Adesine;Boniton;Adrekar;Adenocor;Adenosin;Sandesin;NSC 7652;ADENOSINE
CBNumber:
CB7304660
化学式:
C10H13N5O4
分子量:
267.24
MOL File:
58-61-7.mol

アデノシン 物理性質

融点 :
234-236 °C (lit.)
比旋光度 :
D11 -61.7° (c = 0.706 in water); 9D -58.2° (c = 0.658 in water)
沸点 :
410.43°C (rough estimate)
比重(密度) :
1.3382 (rough estimate)
屈折率 :
1.7610 (estimate)
貯蔵温度 :
2-8°C
溶解性:
Slightly soluble in water, soluble in hot water, practically insoluble in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute mineral acids.
外見 :
Crystalline Powder
酸解離定数(Pka):
3.6, 12.4(at 25℃)
色:
White
光学活性 (optical activity):
[α]20/D 70±3°, c = 2% in 5% NaOH
水溶解度 :
Soluble in water, ammonium hydroxide and dimethyl sulfoxide. Insoluble in ethanol.
Merck :
14,153
BRN :
93029
安定性::
Stable. Incompatible with strong oxidizing agents.
InChIKey:
OIRDTQYFTABQOQ-KQYNXXCUSA-N
CAS データベース:
58-61-7(CAS DataBase Reference)
NISTの化学物質情報:
adenosine(58-61-7)
EPAの化学物質情報:
Adenosine (58-61-7)

安全性情報

Rフレーズ  36/37/38
Sフレーズ  24/25-36/37/39-26
WGK Germany  2
RTECS 番号 AU7175000
10-23
TSCA  Yes
HSコード  29389090
有毒物質データの 58-61-7(Hazardous Substances Data)
毒性 LD50 oral in mouse: > 20gm/kg
化審法 (9)-46

アデノシン 価格 もっと(39)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC093333 アデノシン
Adenosine
58-61-7 25g ¥10000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC093333 アデノシン
Adenosine
58-61-7 100g ¥25000 2021-03-23 購入
東京化成工業 A0152 アデノシン >99.0%(HPLC)(T)
Adenosine >99.0%(HPLC)(T)
58-61-7 25g ¥8900 2021-03-23 購入
東京化成工業 A0152 アデノシン >99.0%(HPLC)(T)
Adenosine >99.0%(HPLC)(T)
58-61-7 5g ¥2900 2021-03-23 購入
関東化学株式会社(KANTO) 01087-52 アデノシン >98.0%(HLC)
Adenosine >98.0%(HLC)
58-61-7 5g ¥2400 2021-03-23 購入

アデノシン MSDS


Adenosine

アデノシン 化学特性,用途語,生産方法

外観

白色~ほとんど白色、結晶~粉末

定義

本品は、次の化学式で表される複素環式化合物である。

溶解性

水に溶け、エタノールにほとんど溶けない。

用途

核酸研究用。

化粧品の成分用途

皮膚コンディショニング剤

効能

抗不整脈薬, 心抑制薬, 心臓疾患診断の負荷誘導, アデノシン受容体作動薬

商品名

アデノスキャン (第一三共)

化学的特性

White or almost white, crystalline powder.

化学的特性

Adenosine is an important nucleoside composed of adenine and ribose. White, crystalline, odorless powder, mild, saline, or bitter taste, quite soluble in hot water, practically insoluble in alcohol. Formed by isolation following hydrolysis of yeast nucleic acid.

使用

antiarrhythmic, cardiac depressant

使用

Nucleotide.

使用

adenosine is an amino acid. Studies indicate anti-wrinkle and skinsmoothing capacities. Although little is written about its direct skin benefit, adenosine plays an important role in biochemical processes. As adenosine triphosphate (ATP) and adenosine diphosphate (ADP), it is involved in energy transfer, and as cyclic adenosine monophosphate (cAMP) in signal transduction.

定義

adenosine: A nucleoside comprisingone adenine molecule linked to ad-ribose sugar molecule. The phosphate-ester derivatives of adenosine,AMP, ADP, and ATP, are of fundamentalbiological importance as carriersof chemical energy.

定義

ChEBI: A ribonucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a beta1N9-glycosidic bond.

brand name

Adenocard (Astellas); Adenoscan (Astellas).

生物活性

Neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes.

臨床応用

Adenosine (Adenocard) is an endogenous nucleoside that is a product of the metabolism of adenosine triphosphate. It is used for the rapid termination of supraventricular arrhythmias following rapid bolus dosing.
Adenosine is approved for the acute management and termination of supraventricular tachyarrhythmias, including A-V nodal reentrant tachycardia and A-V reciprocating tachycardia. Adenosine may be helpful in the diagnosis of atrial flutter.

副作用

Adverse reactions to the administration of adenosine are fairly common; however, the short half-life of the drug limits the duration of such events.The most common adverse effects are flushing, chest pain, and dyspnea. Adenosine may induce profound bronchospasm in patients with known reactive airway disease. The mechanism for bronchospasm is unclear, and the effect may last for up to 30 minutes despite the short half-life of the drug.

薬物相互作用

Metabolism of adenosine is slowed by dipyridamole, indicating that in patients stabilized on dipyridamole the therapeutically effective dose of adenosine may have to be increased. Methylxanthines antagonize the effects of adenosine via blockade of the adenosine receptors.

純化方法

Crystallise adenosine from distilled water and dry it at 110o. It has been purified via the picrate, where ethanolic picric acid is added to adenosine and the picrate is filtered off and recrystallised from EtOH. It has m 180-185o(dec). Adenosine is recovered by dissolving 0.4g of the picrate in 80mL of hot H2O, treated with a small quantity of Dowex 1 anion exchange resin in the chloride form, and the resin is filtered off. The filtrate is treated with more resin and filtered again. One equivalent of aqueous NaOH is added to the colourless filtrate which is evaporated to 4mL and cooled to give 0.176g of adenosine m 236o. [Davoll et al. J Chem Soc 967 1948, Davoll & Lowy J Am Chem Soc 73 1650 1951, Beilstein 26 III/IV 3598.]

予防処置

Patients with second- or third-degree A-V block should not receive adenosine. As indicated previously, the use of adenosine in asthmatic patients may exacerbate the asthmatic symptoms.

アデノシン 上流と下流の製品情報

原材料

準備製品


アデノシン 生産企業

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58-61-7(アデノシン)キーワード:


  • 58-61-7
  • D-ADENOSINE
  • AR
  • (2R,3R,4S,5R)-2-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL
  • 9-BETA-D-RIBOFURANOSYLADENINE
  • Adenine riboside, Adenine-9-beta-ribofuranoside
  • ADENOSINE extrapure for biochemistry
  • 9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside
  • ADENINENUCLEOSIDE
  • ADENINE RIBOSIDE
  • ADENOSINE
  • ADENINE-9-BETA-D-RIBOFURANOSIDE
  • 6-Amino-9-β-D-ribofuranosyl-[9H]-purine
  • 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • ADENOSINE(FREE BASE)(RG)
  • adenine-9-1'-β-ribofuranoside
  • vidarabine,ara-A
  • 9-D-Ribofuranosyl sdenine
  • ADENOSINE[9-BETA-D-RIBOFURANOSYLADENINE]
  • Adenoside
  • (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • ADENOSINE (Ado)
  • adenosin (german)
  • Adesine
  • MONOCLONAL ANTI-ANDROGEN RECEPTOR PROTEIN antibody produced in mouse
  • Adenosine Vetec(TM) reagent grade, 98%
  • ATP DISODIUM TRIHYDRATE ULTRA PURE GRADE
  • Adenine riboside, low endotoxins
  • Adenine-9-β-D-ribofuranoside, low endotoxis
  • Adenosine free base, low endotoxinsCell culture grade, ≥ 99.5% (HPLC)
  • アデノシン
  • β-D-アデノシン
  • 6-アミノ-9-β-D-リボフラノシル-9H-プリン
  • アデノスキャン
  • ミオコール
  • アデニンリボシド
  • β-アデノシン
  • アデノシンリボシド
  • ヌクレオカルジル
  • リボアデノシン
  • ボニトン
  • サンデシン
  • アデノカード
  • 1-(6-アミノ-9H-プリン-9-イル)-1-デオキシ-β-D-リボフラノース
  • 9-(β-D-リボフラノシル)-9H-プリン-6-アミン
  • アデノカルド
  • (-)-アデノシン
  • アデノシン (JAN)
  • ヌクレオシド,ヌクレオチド&関連試薬
  • ヌクレオシドと類似体
  • 生化学
  • 代謝産物
  • 抗不整脈薬
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