ChemicalBook
Chinese english Germany Korea

セフォチアム

セフォチアム 化学構造式
61622-34-2
CAS番号.
61622-34-2
化学名:
セフォチアム
别名:
(6R,7R)-7α-[(2-アミノ-4-チアゾリル)アセチルアミノ]-3-[[[1-[2-(ジメチルアミノ)エチル]-1H-テトラゾール-5-イル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸;セホチアム;セフォチアム;(6R,6β)-7α-[[(2-アミノ-4-チアゾリル)アセチル]アミノ]-3-[[[1-[2-(ジメチルアミノ)エチル]-1H-テトラゾール-5-イル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
英語化学名:
Cefotiam
英語别名:
SCE 963;Texodil;Taketiam;CEFOTIAM;cgp14221e;Pansporin T;CEFOTIAM HCL;(6r-trans)--oxo;Pansporin:Pansporine;Cefotiam Crude N-acetylneuraminic
CBNumber:
CB7367629
化学式:
C18H23N9O4S3
分子量:
525.63
MOL File:
61622-34-2.mol

セフォチアム 物理性質

沸点 :
843℃
RTECS 番号:
XI0366000
闪点 :
>110°(230°F)
水溶解度 :
Soluble
CAS データベース:
61622-34-2(CAS DataBase Reference)

安全性情報

セフォチアム 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

セフォチアム 化学特性,用途語,生産方法

効能

抗生物質, 細胞壁合成阻害薬

使用

Antibacterial

定義

ChEBI: A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalospo in antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.

brand name

Ceradon (Takeda).

抗菌性

A semisynthetic cephalosporin formulated as the dihydrochloride for injection and as a prodrug ester, cefotiam hexetil, for oral administration. Activity is similar to that of cefuroxime, but it is somewhat more active against a range of enterobacteria .
A 30-min intravenous infusion of the dihydrochloride produces a peak serum concentration of 35 mg/L; the corresponding concentration after a 1 g intramuscular dose is 17 mg/L. Oral absorption of the hexetil ester is around 65%. Food delays absorption of the ester. The plasma half-life is 0.6–1.1 h. Around 40% is bound to plasma protein. Urinary excretion is almost complete 4 h after the end of intravenous infusion, but only 50–67% is recovered unchanged; there is substantial non-renal elimination and some evidence of saturation of renal tubular excretion at doses above 2 g. In anuria the plasma elimination half-life rises to 13 h and plasma and renal clearances parallel creatinine clearance. A small amount is excreted in bile. In patients with cholelithiasis given 0.5 or 1 g intravenously, mean concentrations in gallbladder bile and gallbladder wall 30 min after the dose were around 17 and 32 mg/L, respectively. In patients with normal liver function, hepatic bile concentrations can exceed 1 g/L.
It is generally well tolerated and has been used successfully to treat lower respiratory infections, skin and soft-tissue infection. It is not widely used, but is available in Japan and some other countries.

セフォチアム 上流と下流の製品情報

原材料

準備製品


セフォチアム 生産企業

Global( 66)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19923 58
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029 sales@ouhechem.com China 12500 60
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9103 52
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9409 52
Wuhan Fortuna Chemical Co., Ltd +86-27-59207852 85767163
+86-27-59524646 info@fortunachem.com China 2937 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12343 58
(CSR Factory)China Skyrun Industrial CO.,ltd Please Email
manager@chinaskyrun.com sales@chinaskyrun.com China 12128 58

61622-34-2(セフォチアム)キーワード:


  • 61622-34-2
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, (6R-trans)-
  • SCE 963
  • Cefotiam (base and/or unspecified salts)
  • (6R-trans)-7-[[(2-Amino-4-thiazlyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-y1]thio]methyl]-8-oxo-5-thia-1-azabi-cyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Pansporin T
  • Pansporin:Pansporine
  • Taketiam
  • Texodil
  • (6R,7R)-7α-[(2-Amino-4-thiazolyl)acetylamino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-, (6R,7R)-
  • Cefotiam Crude N-acetylneuraminic
  • (6r-trans)--oxo
  • )acetyl)amino)-3-(((1-(2-(dimethylamino)ethyl)-1h-tetrazol-5-yl)thio)methyl)-8
  • cgp14221e
  • 8-[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino-4-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
  • CEFOTIAM
  • CEFOTIAM HCL
  • (6R,7R)-7α-[(2-アミノ-4-チアゾリル)アセチルアミノ]-3-[[[1-[2-(ジメチルアミノ)エチル]-1H-テトラゾール-5-イル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セホチアム
  • セフォチアム
  • (6R,6β)-7α-[[(2-アミノ-4-チアゾリル)アセチル]アミノ]-3-[[[1-[2-(ジメチルアミノ)エチル]-1H-テトラゾール-5-イル]チオ]メチル]-8-オキソ-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸
  • セファロスポリン類
Copyright 2017 © ChemicalBook. All rights reserved