キナルジン 化学特性,用途語,生産方法
外観
無色～黄褐色, 澄明の液体
溶解性
水に不溶。エーテル, アセトンに易溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。
用途
有機合成原料。
使用上の注意
不活性ガス封入
化学的特性
Quinaldine or 2-methylquinoline is an organic compound with the formula CH3C9H6N. It is one of the methyl derivative of a heterocyclic compound quinoline. It is bioactive and is used in the preparation of various dyes. It is a colorless oil but commercial samples can appear colored.
使用
Quinaldine is an anaesthetic used in fish transportation. Also used in anti-malaria drugs, in manufacturing dyes, food colorants , pharmaceuticals and pH indicators.
定義
ChEBI: A quinoline compound in which the quinoline skeleton is substituted at C-2 with a methyl group.
調製方法
High-temperature coal tar contains an average of 0.2% quinaldine. It is recovered from the quinoline base mixture by rectification and hydration. Quinaldine can be synthesized by the Skraup method from aniline and crotonaldehyde with sulfuric acid in the presence of a dehydrogenating agent.
一般的な説明
A colorless oily liquid darkening to red-brown on exposure to air. Flash point 175°F. Denser than water and slightly soluble in water. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used to make dyes, pharmaceuticals and other chemicals.
空気と水の反応
Slightly soluble in water.
反応プロフィール
Quinaldine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Keep tightly closed and protected from light .
危険性
Strong irritant to mucous membranes.
火災危険
Quinaldine is probably combustible.
純化方法
Dry it with Na2SO4 or by refluxing with BaO, then fractionally distil it under reduced pressure and redistil it from zinc dust. Purify it further by conversion to its phosphate (m 220o) or picrate (m 192o) from which after recrystallisation, the free base is regenerated. [Packer et al. J Am Chem Soc 80 905 1958.] Its ZnCl2 complex can be used for the same purpose. [Beilstein 20 III/IV 3454, 20 V 375.]
キナルジン 上流と下流の製品情報
原材料
イソキノリン
Column plate
Dibromo
コールタールナフサ （MIDDLE TAR DISTILLATE (COAL)）
Polishing oil
ブチルアルデヒド
Quinoline, 1,2-dihydro-2-methyl-
Quinoline, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methyl-
キノリンN-オキシド水和物
2-メチルキノリン1-オキシド
2-アミノベンジルアルコール
1,2,3,4-テトラヒドロキナルジン
6-メトキシ-2-メチルキノリン
2-メチル-N-フェニル-1,2,3,4-テトラヒドロキノリン-4-アミン
4-クロロ-2-メチルキノリン
2-ニトロベンズアルデヒド
N-エチルアニリン
準備製品