アタパルジャイト 化学特性,用途語,生産方法
定義
本品は、ジョージア州アタパルガス近郊で発見されたフラー土(*)の一種である。他の粘土鉱物の通常の重膜構造よりも、むしろ鎖状構造を有することにより特色付けられている。参照表示名称：フラー土
化粧品の成分用途
不透明化剤、親水性増粘剤、吸着剤、研磨.スクラブ剤、増量剤
化学的特性
Attapulgite occurs as a light cream colored, very fine powder.
Particle size ranges depend on the grade and manufacturer.
使用
Worldwide attapulgite production in 1983 was estimated
at about 1.1 million tons, of which 84% came from the United
States. The primary use of attapulgite is as an animal
waste absorbent (cat litter). Other important uses of attapulgite
in the United States are as a component of drilling muds,
as oil and grease absorbents, and in fertilizer and pesticide
formulations.
調製方法
Attapulgite occurs naturally as the mineral palygorskite.
定義
A
hydrated aluminum-magnesium silicate, the chief
ingredient of fuller’s earth.
危険性
Possible carcinogen.
応用例（製薬）
Attapulgite is widely used as an adsorbent in solid dosage forms.
Colloidal clays (such as attapulgite) absorb considerable amounts of
water to form gels and in concentrations of 2–5% w/v usually form
oil-in-water emulsions. Activated attapulgite, which is attapulgite
that has been carefully heated to increase its absorptive capacity, is
used therapeutically as an adjunct in the management of diarrhea.
安全性プロファイル
Suspected carcinogen with experimental neoplastigenic and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
安全性
Attapulgite is widely used in pharmaceutical formulations and is
generally regarded as an essentially nontoxic and nonirritant
material. It is not absorbed following oral administration. In oral
preparations, activated attapulgite up to 9 g is used in daily divided
doses as an adjunct in the management of diarrhea.
貯蔵
Attapulgite can adsorb water. It should be stored in an airtight
container in a cool, dry, location.
不和合性
Attapulgite may decrease the bioavailability of some drugs such as
loperamide and riboflavin. Oxidation of hydrocortisone is
increased in the presence of attapulgite.
規制状況(Regulatory Status)
Included in nonparenteral medicines licensed in a number of
countries worldwide including the UK and USA.
アタパルジャイト 上流と下流の製品情報
原材料
準備製品