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BGC 20-1531 (hydrochloride)

化学構造式
1962928-26-2
CAS番号.
1962928-26-2
化学名:
别名:
英語名:
BGC 20-1531 (hydrochloride)
英語别名:
AP 1531;BGC20-1531 (PGN-1531;AP-1531 hydrochloride;GTPL3380 hydrochloride;BGC 20-1531 (hydrochloride);BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base);4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
CBNumber:
CB74666962
化学式:
C26H25ClN2O6S
分子量:
529
MOL File:
1962928-26-2.mol

BGC 20-1531 (hydrochloride) 物理性質

貯蔵温度 :
Store at -20°C
溶解性:
DMF: 1 mg/ml; DMSO: 1 mg/ml
外見 :
A crystalline solid

安全性情報

BGC 20-1531 (hydrochloride) 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

BGC 20-1531 (hydrochloride) 化学特性,用途語,生産方法

説明

BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; ) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs.

BGC 20-1531 (hydrochloride) 上流と下流の製品情報

原材料

準備製品

BGC 20-1531 (hydrochloride) 生産企業

Global( 26)Suppliers
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Career Henan Chemica Co 		+86-0371-86658258 15093356674;
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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TargetMol Chemicals Inc. 		+1-781-999-5354
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Shanghai Hongye Biotechnology Co. Ltd 400-9205774
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Shanghai Luofa Biochemical Technology Co., Ltd. 021-51111890 15317326293
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Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
3477467573@qq.com China 8618 58

  スペクトルデータ(1HNMR)

BGC 20-1531 (hydrochloride)(1962928-26-2)1HNMR
  • 1962928-26-2
  • BGC 20-1531 (hydrochloride)
  • AP 1531
  • BGC20-1531 (PGN-1531
  • 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
  • GTPL3380 hydrochloride
  • AP-1531 hydrochloride
  • BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base)
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