DS-437

1674364-87-4

CAS番号.: 1674364-87-4

化学名:

别名:

英語名:: DS-437

英語别名:: DS-437;DS-437 (DS437;DS-437 >=98% (HPLC);Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-

CBNumber:: CB74669958

化学式:: C15H23N7O4S

分子量:: 397.45

MOL File:: 1674364-87-4.mol

MSDS File:: SDS

物理性質

安全性情報

価格2

用途語

生産企業 15

DS-437 物理性質

比重(密度) :: 1.71±0.1 g/cm3(Predicted)

貯蔵温度 :: 2-8°C

溶解性:: DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)

酸解離定数(Pka):: 13.13±0.70(Predicted)

外見 :: 粉

色:: 白からベージュ

安全性情報

リスクと安全性に関する声明
危険有害性情報のコード(GHS)

RIDADR	UN 2811 6.1 / PGIII

絵表示（GHS）

注意喚起語

危険

危険有害性情報

コード	危険有害性情報	危険有害性クラス	区分	注意喚起語	シンボル	P コード
H301	飲み込むと有毒	急性毒性、経口	3	危険		P264, P270, P301+P310, P321, P330,P405, P501

注意書き

DS-437 価格もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	SML1516	≥98% (HPLC) DS-437 ≥98% (HPLC)	1674364-87-4	5mg	￥17800	2024-03-01	購入
Sigma-Aldrich Japan	SML1516	≥98% (HPLC) DS-437 ≥98% (HPLC)	1674364-87-4	25mg	￥57600	2024-03-01	購入

DS-437 化学特性,用途語,生産方法

説明

DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC₅₀s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC₅₀s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185^erbB2/neu antibody 4D5.

使用

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Biochem/physiol Actions

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

DS-437 上流と下流の製品情報

原材料

準備製品

DS-437 生産企業

Global( 15)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44894	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
InvivoChem	13549236410	sales@invivochem.cn	China	6712	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

1674364-87-4
DS-437
DS-437 (DS437
Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-
DS-437 >=98% (HPLC)