4-アミノアンチピリン 化学特性,用途語,生産方法
外観
わずかにうすい黄色～うすい黄褐色, 結晶～結晶性粉末
溶解性
水及びエタノールに溶けやすく、ジエチルエーテルに溶けにくい。水及びエタノールに溶けやすく、ジエチルエーテルに溶けにくい。
用途
フェノール定量、有機合成用。
用途
アンピロン（英:Ampyrone）は、抗炎症剤、解熱鎮痛剤、解熱剤の特性を有するアミノピリンの代謝産物である。顆粒球減少症の危険性のために薬剤としての使用は推奨されていない。その代わりに、過酸化物またはフェノールを生成する生化学反応の試薬として使用されている。アンピロンは、肝ミクロソームを刺激し、また、細胞外液を測定するために使用されている。
使用上の注意
不活性ガス封入
化学的特性
Amber crystalline powder
主な応用
4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample.
使用
4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.
定義
ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine.
製造方法
synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine.
一般的な説明
4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals.
純化方法
It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]
4-アミノアンチピリン 上流と下流の製品情報
原材料
準備製品