メチルエフェドリン

メチルエフェドリン 化学特性,用途語,生産方法

効能

気管支拡張薬, アドレナリン受容体作動薬

説明

The Chinese plant 'Ma-Huang' contains this alkaloid, first isolated by Smith. According to Read, the name 'Ma-Huang' is the name for various Ephedra species but the material principally used in China is E. sinica Stapf. (Syn. E. j7ava Porter Smith, E. Mahuang Liu). It has subsequently been discovered in European species, notably E. helvetica C. A. Meyer and E. distachya Linn. The alkaloid crystallizes in stout, colourless needles and has [α]_D - 29.2° (MeOH). It yields several crystalline salts and derivatives: hydrochloride, m.p. 188-9°C; [α]²⁰_D - 29.8° (H20); oxalate, m.p. 187°C; aurichloride, m.p. 128-9°C; picrate, m.p. 144°C and the methiodide, m.p. 212-3°C; [α]_D - 21.8° (H20).

化学的特性

White crystals or adhering crystalline powder

使用

adrenergic agonist, analeptic

純化方法

N-Methylephedrine has been recrystallised from Et2O, pet ether, of aqueous EtOH or aqueous MeOH and has been distilled under reduced pressure. [Smith J Chem Soc 2056 1927, Tanaka & Sugawa Yakugaku Zasshi (J Pharm Soc Japan) 72 1548 1952 (Chem Abstr 47 8682 1953), Takamatsu Yakugaku Zasshi (J Pharm Soc Japan) 76 1227 1956, Chem Abstr 51 4304 1957.] The hydrochloride has m 192-193o and [] D (c 5,H2O)[Prelog & Hüfliger Helv Chim Acta 33 2021 1950].20+30o [Beilstein 13 IV 1884.]

参考文献

Smith., J. Chern. Soc., 2056 (1927)
Smith., ibid, 51 (1928)
Smith., ibid, 2755 (1929)
Wolfes., Arch. Pharrn., 268,327 (1930)
Preparation:
Nagai., J. Pharrn. Soc., Japan, No. 120, 109 (1892)
Nagai, Kanao., ibid, 48, 145 (1928)

メチルエフェドリン 上流と下流の製品情報

原材料

準備製品

552-79-4(メチルエフェドリン)キーワード:

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• 552-79-4
• METHYLESCULETIN, 4-(RG)
• (1R,2S)-3-Dimethylamino-1-phenyl-1-propanol
• Benzenemethanol, α-[(1S)-1-(dimethylamino)ethyl]-, (αR)-
• Benzenemethanol, α-[1-(dimethylamino)ethyl]-, [R-(R*,S*)]-
• N-Methyl-L-ephedrine
• (1R,2S)-(-)-N-METHYLEPHEDRINE
• (-)-1R,2S-METHYLEPHEDRINE
• (-)-(1R,2S)-2-DIMETHYLAMINO-1-PHENYLPROPANOL
• (IR,2S)-I-N-Methylephedrine Base
• METHYLEPHEDRINE, (-)-1R,2S SNAPN 1.0mg/mL(SH)
• N-Methylephedrine (base and/or unspecified salts)
• (-)-N-Methylephedrine, 98+%
• (-)-N-Methylephedrine, (-)-(1R,2S)-2-Dimethylamino-1-phenylpropanol, [R-(R*,S*)]-α-[1-(Dimethylamino)ethyl]benzenemethanol
• (-)-N-Methylephedrine,99%
• [R-(R,S)]-α-[1-(Dimethylamino)ethyl]benzenemethanol
• Methanol(Test Methylephedrine, 1.0 mg/mL)
• N-METHYL (-)EPHEDRINE [1R,2S]
• Methylephedrine solution
• (1Rs,2Rs)-2-dimethylamino-1-phenylpropan-1-ol
• -[1-(Dimethylamino)ethyl]benzenemethanol
• [R,(-)]-α-[(S)-1-(Dimethylamino)ethyl]benzyl alcohol
• Dimethyl-ephedrine
• METHYLEPHEDRINE, (-)-1R,2S-
• METHYLEPHEDRINE, (-)-1R,2S N-
• Benzenemethanol, alpha-[1-(dimethylamino)ethyl]-, [R-(R*,S*)]-
• Erythro-alpha-[1-(dimethylamino)ethyl]benzyl alcohol
• N,N-Dimethylnorephedrine
• N,N-Dimethylnorephedrine2-dimethylamino-1-phenylpropanol
• [R-(R*,S*)]-ALPHA-[1-(DIMETHYLAMINO)ETHYL]BENZENEMETHANOL
• (-)-N-METHYLEPHEDRINE
• (1R,2S)-1-フェニル-2-(ジメチルアミノ)-1-プロパノール
• (-)-メチルエフェドリン
• (R)-α-[(S)-1-(ジメチルアミノ)エチル]ベンゼンメタノール
• (αR)-α-[(S)-1-(ジメチルアミノ)エチル]ベンゼンメタノール
• l-N-メチルエフェドリン
• (1R,2S)-N-メチルエフェドリン
• [R,(-)]-α-[(S)-1-(ジメチルアミノ)エチル]ベンゼンメタノール
• (1R,2S)-1-フェニル-2-(ジメチルアミノ)プロパン-1-オール
• ジメチルエフェドリン
• (1R,2S)-2-(ジメチルアミノ)-1-フェニル-1-プロパノール
• (1R,2S)-1-フェニル-2-ジメチルアミノ-1-プロパノール
• l-メチルエフェドリン
• (-)-N-メチルエフェドリン
• [R,(-)]-α-[(S)-1-(ジメチルアミノ)エチル]ベンジルアルコール
• メチルエフェドリン
• (1R,2S)-N,N-ジメチルノルエフェドリン
• (1R,2S)-2-(ジメチルアミノ)-1-フェニルプロパン-1-オール
• (1R,2S)-2-ジメチルアミノ-1-フェニル-1-プロパノール