アトシバン
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- CAS番号.
- 90779-69-4
- 化学名:
- アトシバン
- 别名:
- アトシバン;アトシバン、ヒト由来;アトシバンアセタート;3-メルカプト(1)プロピオニル-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2;2-デアミノ-L-Cys(1)-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2;(2S)-5-アミノ-2-{[(2S)-1-[(4R,7S,10S,13S,16R)-13-[(2S)-ブタン-2-イル]-7-(カルバモイルメチル)-16-[(4-エトキシフェニル)メチル]-10-[(1R)-1-ヒドロキシエチル]-6,9,12,15,18-ペンタオキソ-1,2-ジチア-5,8,11,14,17-ペンタアザシクロイコサン-4-カルボニル]ピロリジン-2-イル]ホルムアミド}-N-(カルバモイルメチル)ペンタンアミド;N-[3-メルカプト(1)プロパノイル]-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2;2-デアミノ-L-Cys(1)-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asp(NH2)-L-Cys(1)-L-Pro-L-Orn-Gly-NH2;アントシンII;[Mpa1,D-Tyr(Et)2,Thr4,Orn8]オキシトシン;3-メルカプト(1)プロパノイル-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
- 英語名:
- Atosiban
- 英語别名:
- Antocin;rwj22164;Atosiban;RW-22164;ORF22164;ORF 22164;ORF-22164;14-Deoxy-11;atosiban price;Human Atosiban
- CBNumber:
- CB7497854
- 化学式:
- C43H67N11O12S2
- 分子量:
- 994.19
- MOL File:
- 90779-69-4.mol
- MSDS File:
- SDS
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アトシバン 物理性質
- 融点 :
- >165oC (dec.)
- 沸点 :
- 1469.0±65.0 °C(Predicted)
- 比重(密度) :
- 1.254±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- H2O: ≤100 mg/mL
- 外見 :
- 個体
- 酸解離定数(Pka):
- 12.81±0.70(Predicted)
- 色:
- ホワイトからオフホワイト
- 水溶解度 :
- Soluble to 50 mg/ml in water
- CAS データベース:
- 90779-69-4(CAS DataBase Reference)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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A3480 |
アトシバン ≥98% (HPLC)
Atosiban ≥98% (HPLC) |
90779-69-4 |
10mg |
￥59100 |
2024-03-01 |
購入 |
アトシバン 化学特性,用途語,生産方法
効能
子宮収縮抑制薬, オキシトシン受容体拮抗薬
説明
Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major
cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of
the vasopressin V
1a receptor and of the oxytocin receptor which is found in dramatically
increased concentration in the uterine myometrium of pregnant women near term. It
competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin
and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with
atosiban caused pregnancy prolongation for up to 7 days in women with more than 28
weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic
action (uterine relaxant) to ritodrine but the former was significantly better tolerated,
especially with regards to maternal cardiovascular side effects. In healthy volunteers,
plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.
使用
Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.
適応症
Atosiban is an analogue of oxytocin that is modified at
positions 1, 2, 4, and 8. It is a competitive inhibitor of
oxytocin binding. Early studies have demonstrated that
this drug does decrease and stop uterine contractions.
Atosiban is not available for use in the United States.
抗がん研究
The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).
アトシバン 上流と下流の製品情報
原材料
準備製品
アトシバン 生産企業
Global( 344)Suppliers
90779-69-4(アトシバン)キーワード:
- 90779-69-4
- 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin
- oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l
- rwj22164
- 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin
- [Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2
- (2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
- 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
- 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin
- Atosiban
- Human Atosiban
- 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile, 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
- Atosiban,1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin, 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile
- Atosiban, RWJ 22164
- Oxytropis Falcata
- AtosibanAcetate(Tractocile)
- 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
- Atosiban impurity 1
- Atosiban, >=98%
- (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, Atosiban
- 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
- ATOSIBAN ACETATE
- Glycinamide, O-ethyl-N-(3-mercapto-1-oxopropyl)-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithyl-, cyclic (1→5)-disulfide
- Atosiban impurity
- Atosiban Impurity 41
- Atosiban USP/EP/BP
- Atosiban
DISCONTINUED PLEASE SEE A791890
- Atosiban acetate salt
- (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
- (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)p
- AtosibanQ: What is
Atosiban Q: What is the CAS Number of
Atosiban Q: What is the storage condition of
Atosiban Q: What are the applications of
Atosiban
- アトシバン
- アトシバン、ヒト由来
- アトシバンアセタート
- 3-メルカプト(1)プロピオニル-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
- 2-デアミノ-L-Cys(1)-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
- (2S)-5-アミノ-2-{[(2S)-1-[(4R,7S,10S,13S,16R)-13-[(2S)-ブタン-2-イル]-7-(カルバモイルメチル)-16-[(4-エトキシフェニル)メチル]-10-[(1R)-1-ヒドロキシエチル]-6,9,12,15,18-ペンタオキソ-1,2-ジチア-5,8,11,14,17-ペンタアザシクロイコサン-4-カルボニル]ピロリジン-2-イル]ホルムアミド}-N-(カルバモイルメチル)ペンタンアミド
- N-[3-メルカプト(1)プロパノイル]-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
- 2-デアミノ-L-Cys(1)-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asp(NH2)-L-Cys(1)-L-Pro-L-Orn-Gly-NH2
- アントシンII
- [Mpa1,D-Tyr(Et)2,Thr4,Orn8]オキシトシン
- 3-メルカプト(1)プロパノイル-O-エチル-D-Tyr-L-Ile-L-Thr-L-Asn-L-Cys(1)-L-Pro-L-Orn-Gly-NH2