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ジムピラート

ジムピラート 化学構造式
333-41-5
CAS番号.
333-41-5
化学名:
ジムピラート
别名:
チオりん酸=O-(2-イソプロピル-6-メチル-4-ピリミジニル)=O,O-ジエチル;バスジン;ジアジノン;ダイアジノン;スペクトラシド;チオりん酸O,O-ジエチルO-(2-イソプロピル-6-メチル-4-ピリミジニル);チオりん酸O,O-ジエチル-O-(2-イソプロピル-6-メチル-4-ピリミジニル);ネオシドール;ジムピラート;サロレックス;ホスホロチオ酸O,O-ジエチルO-(2-イソプロピル-6-メチルピリミジン-4-イル);ヌシドール;ジアジトール;スペクトラシード;ダイアジトール;ダイアジノン標準液;ダイアジノン標準品;O,O-ジエチルO-(2-イソプロピル-6-メチルピリジン-4-イル)ホスホロチオアート;2-イソプロピル-4-メチルピリミジル-6-ジエチルチオホスフェイト;チオりん酸O,O-ジエチル-O-(2-イソプロピル-6-メチル-4-ピリミジニル) (別名 ダイアジノン)
英語化学名:
Diazinon
英語别名:
Anti;g301;Dicid;dyzol;G 301;pt265;DIAZOL;DIANON;Anti-Y;AG-500
CBNumber:
CB7702086
化学式:
C12H21N2O3PS
分子量:
304.35
MOL File:
333-41-5.mol

ジムピラート 物理性質

融点 :
>120°C (dec.)
沸点 :
306°C
比重(密度) :
1.117
蒸気圧:
1.2 x 10-2 Pa (25 °C)
屈折率 :
nD20 1.4978-1.4981
闪点 :
104.4 °C
貯蔵温度 :
APPROX 4°C
酸解離定数(Pka):
1.21±0.30(Predicted)
外見 :
neat
水溶解度 :
Slightly soluble. 0.004 g/100 mL
Merck :
13,3019
BRN :
273790
暴露限界値:
OSHA PEL: TWA 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3.
CAS データベース:
333-41-5(CAS DataBase Reference)
IARC:
2A (Vol. 112) 2017
NISTの化学物質情報:
Diazinone(333-41-5)
EPAの化学物質情報:
Diazinon (333-41-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn;N,N,Xn,F
Rフレーズ  22-50/53-36-20/21/22-11-51/53
Sフレーズ  24/25-60-61-36-26-16-36/37
RIDADR  UN 2783/2810
WGK Germany  3
RTECS 番号 TF3325000
国連危険物分類  6.1(b)
容器等級  III
HSコード  29335990
有毒物質データの 333-41-5(Hazardous Substances Data)
毒性 LD50 in male, female rats (mg/kg): 250, 285 orally (Gaines)
消防法 危-4-3-III
化審法 一般化学物質
安衛法 57,57-2
PRTR法 第1種指定化学物質
毒劇物取締法 III
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H312 皮膚に接触すると有害 急性毒性、経皮 4 警告 P280,P302+P352, P312, P322, P363,P501
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H350 発がんのおそれ 発がん性 1A, 1B 危険
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
H411 長期的影響により水生生物に毒性 水生環境有害性、慢性毒性 2
注意書き
P201 使用前に取扱説明書を入手すること。
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。

ジムピラート 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSM-8140-06 ダイアジノン Standard
Diazinon Standard, 1000 ug/mL in Hexane
333-41-5 1mL ¥7400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01ACSM-622-06 ダイアジノン Standard
Diazinon Standard, 1000 ug/mL in Hexane
333-41-5 1mL ¥7400 2021-03-23 購入
関東化学株式会社(KANTO) 49833-57 ダイアジノン標準液
Diazinon standard solution
333-41-5 10mL ¥7000 2021-03-23 購入
関東化学株式会社(KANTO) 49801-25 ダイアジノン標準品
Diazinon standard
333-41-5 250mg ¥11000 2021-03-23 購入
Sigma-Aldrich Japan 68486 ダイアジノン certified reference material, TraceCERT?
Diazinon certified reference material, TraceCERT?
333-41-5 50mg ¥5600 2021-03-23 購入

ジムピラート 化学特性,用途語,生産方法

解説

ダイアジノン,有機リン殺虫剤の一種。スイスのガイギー社が1952年に開発した有機リン酸エステル系殺虫剤の一種。各種の衛生・農業害虫に対し使用。一般名,商品名ともダイアジノンである。ニカメイチュウ,ウンカ,ヨコバイなどのイネ害虫をはじめ広範囲の害虫に対して殺虫力を示し,哺乳類に対する急性毒性は,50%致死量LD50=250mg/kg(ラット(雄),経口)とかなり低い。沸点 83~84℃の無色液体。水に難溶,有機溶媒によく溶ける。果樹,蔬菜の各種害虫,はえ,蚊,ごきぶりなどの衛生害虫の防除に用いられる。接触毒,食毒のほかガス毒として作用。茎葉散布,土壌施用剤,水面施用剤,燻煙剤など用途が広い。

用途

農薬(殺虫剤) (NITE CHRIP)

効能

殺虫薬 (獣医薬), アセチルコリンエステラーゼ阻害薬

農薬用途

動物薬、殺虫剤、ダニ駆除剤

説明

Diazinon is a non-systemic organophosphate insecticide formerly used to control cockroaches, silverfish, ants, and fleas in residential, non-food buildings. Diazinon functions as the inhibitor of acetylcholinesterase (AChE), which breaks down the neurotransmitter acetylcholine (ACh) into [choline] and an acetate group. The inhibition of the AChE causes an abnormal accumulation of ACh in the synaptic cleft. However, recent studies have shown that diazinon and other kinds of organophosphate can cause neural toxicity through causing oxidative stress in the neural cells.

化学的特性

Diazinon is available as a colorless or dark brown liquid. It is sparingly soluble in water but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control of a variety of agricultural and household pests. These include pests in soil, on ornamental plants, fruit, vegetable, crops pests, and household pests like fl ies, fl eas, and cockroaches. Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes, such as nitrogen oxides, phosphorous oxides, and sulfur oxides. It reacts with strong acids and alkalis with the possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon is classifi ed as an RUP. Depending on the type of formulation, diazinon is classifi ed as toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic.

使用

Diazinon is used to control a wide range of sucking and chewing insects and mites in a very wide range of crops and is also used as a veterinary ectoparasiticide.

定義

ChEBI: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.

作用機構

作用機構はアセチルコリンエステラーゼ活性阻害である。本剤は他の有機リン酸エステル系殺虫剤およびカーバメート系殺虫剤に対して抵抗性を取得したツマグロヨコバイに殺虫力を示し,また有機リン酸エステル系殺虫剤などによって薬害を生じやすいトマト,ウリ類,果樹などに薬害が生じにくいという特徴を有する。

一般的な説明

Diazinon is available in the form of a colourless or dark brown liquid. It is sparingly soluble in water but very soluble in petroleum ether, alcohol, and benzene. Diazinon is used for the control of a variety of agriculture and household pests. These include pests in soil, on ornamental plants, fruit, vegetable, and crops and household pests like flies, fleas, and cockroaches. Diazinon undergoes decomposition on heating above 120°C and produces toxic fumes such as nitrogen oxides, phosphorus oxides, and sulphur oxides. It reacts with strong acids and alkalis with possible formation of highly toxic tetra ethyl thiopyrophosphates. Diazinon is classified as a RUP. Depending on the type of formulation, diazinon is classified as toxicity class II, meaning moderately toxic, or toxicity class III, meaning slightly toxic.

空気と水の反応

The neat compound is susceptible to oxidation and should be protected from prolonged exposure to air . Insoluble in water.

健康ハザード

Humans are exposed to diazinon during manufacture and professional applications. Diazinon causes poisoning with symptoms such as headache, dizziness, nausea, weakness, feelings of anxiety, vomiting, pupillary constriction, convulsions, respiratory distress or labored breathing, unconsciousness, muscle cramp, excessive salivation, respiratory failure, and coma.

火災危険

Not flammable. POISONOUS GASES ARE PRODUCED WHEN HEATED. Oxides of sulfur and of phosphorus are generated in fires.

製品名

AG-500®; AI3-19507®; ALFA-TOX®[C]; ANTIGAL®; ANTLAK®; BASUDIN®; BAZUDEN®; CASWELL No. 342®; DACUTOX®; DASSITOX®; DAZZEL®; DIAGRAN®; DIANON®; DIATERR-FOS®; DIAZAJET®; DIAZATOL®; DIAZIDE®; DIAZINON AG 500 WBC®; DIAZINONE®; DIAZITOL®; DIAZOL®; DICID®; DIMPYLATE®; DIPOFENE®; DIZIKTOL®; DIZINON®[C]; DRAWIZON®; DYMET®; DYZOL®); D.Z.N.®; EXODIN®; FEZUDIN®; FLYTROL®; G 301®; G-24480®; GALESAN®; GARDENTOX®; GEIGY 24480®; KAYAZINON®; KAYAZOL®; NEOCIDOL® (OIL); NEOCIDOL®; NIPSAN®; NUCIDOL®; OLEODIAZINON®; ROOT GUARD; SAROLEX®[C]; SPECTRACIDE®; SROLEX®; SUZON®

安全性プロファイル

Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by ingestion: changes in motor activity, muscle weakness, and sweating. Experimental teratogenic and reproductive effects. A skin and severe eye irritant. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, POx, and SOx.

職業ばく露

roducers, formulators and applicators of this nonsystemic pesticide and acaricide. Diazinon is used in the United States on a wide variety of agricultural crops, ornamentals, domestic animals; lawns and gardens; and household pests.

発がん性

Among 23,106 male applicators participating in the Agricultural Health Study who reported using diazinon, there was an increased risk with exposure to diazinon for lung cancer, leukemia, and all cancer sites combined, although the small number of cases observed makes these estimates unreliable .

代謝経路

The main route of diazinon metabolism in soil, plants and animals is through cleavage of the P-O-pyrimidine group to yield 2-isopropyl-4- methyl-6-hydroxypyrimidine. As with most other phosphorothioates, loss of the pyrimidinyl function in mammalian metabolism probably occurs either through oxidative desulfuration of the thiono group, catalysed by microsomal mixed function oxidases, to give diazoxon followed by hydrolysis catalysed by an A-esterase, or via an oxidative mechanism catalysed by a mixed function oxidase acting directly on diazinon. In the first case the second product is diethyl phosphate and in the second, diethyl phosphorothioate (Yang et al., 1971). Further metabolism then leads to hydroxylation of the methyl and isopropyl groups on the pyrimidine ring. This oxidative metabolism may the act on the pyrimidinol, diazoxon or diazinon itself, the last of which seems to be important in mammalian and avian liver and gives rise to metabolites which still have anticholinesterase or latent anticholinesterase activity.

代謝

The main biodegradation pathway in mammals, plants, and soils is pyrimidinyl ester bond cleavage; the principal metabolites are diethyl phosphorothioate and diethyl phosphate. Degradation in the environment involves oxidation to diazoxon and hydrolysis.

輸送方法

UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

不和合性

Reaction with nitrosating agents (e.g., nitrites, nitrous gases, nitrous acid) capable of releasing carci- nogenic nitrosamines. Hydrolyzes slowly in water and dilute acid. Reacts with strong acids and alkalis with possible forma- tion of highly toxic tetraethyl thiopyrophosphates. Incompatible with copper-containing compounds. Contact with oxidizers may cause the release of phosphorous oxides. Contact with strong reducing agents, such as hydrides; may cause the formation of flammable and toxic phosphine gas.

廃棄物の処理

Diazinon is hydrolyzed in acid media about 12 times as rapidly as parathion, and at about the same rate as parathion in alkaline media. In excess water this compound yields diethylthiophosphoric acid and 2-isopropyl-4-methyl-6-hydroxypyrimidine. With insufficient water, highly toxic tetraethyl monothiopyropho- sphate is formed. Therefore, incineration would be a prefer- able ultimate disposal method with caustic scrubbing of the incinerator effluent . In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by follow- ing package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

予防処置

Workers should avoid eye contact with diazinon, wear chemical safety glasses or goggles, protective clothing or equipment, wear waterproof boots, long-sleeved shirts, long pants, and a hat. Workers should avoid contamination of food and feed, wash thoroughly after handling and before eating or smoking. In fact, occupational workers should avoid eating, drinking, or smoking in areas of work with the chemical.

参考文献

Uner, N, et al. "Effects of diazinon on acetylcholinesterase activity and lipid peroxidation in the brain of Oreochromis niloticus." Environmental Toxicology & Pharmacology 21.3(2006):241.
Shishido, Takashi, K. Usui, and J. I. Fukami. "Oxidative metabolism of diazinon by microsomes from rat liver and cockroach fat body." Pesticide Biochemistry & Physiology 2.1(1972):27-38.
Giordano, G, et al. "Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency." Toxicology & Applied Pharmacology 219.2-3(2007):181.

ジムピラート 上流と下流の製品情報

原材料

準備製品


ジムピラート 生産企業

Global( 232)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
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Zhuozhou Wenxi import and Export Co., Ltd
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333-41-5(ジムピラート)キーワード:


  • 333-41-5
  • O,O-diethylO-(2-isopropyl-6-methyl-4-pyrimidinyl)thiophosphate
  • O,O-diethylO-(2-isopropyl-6-methyl-4-pyrimidinyl)-thiophosphate
  • O,O-diethylO-(2-isopropyl-6-methyl-4-pyrimidinyl)thio-phosphate
  • o,o-diethylo-6-methyl-2-isopropyl-4-pyrimidinylphosphorothioate
  • o,o-dietil-o-(2-isopropil-4-metil-pirimidin-6-il)-monotiofosfato
  • O-2-Isopropyl-4-methylpyrimidyl-O,O-diethyl phosphorothioate
  • o-2-isopropyl-4-methylpyrimidyl-o,o-diethylphosphorothioate
  • O,O-DIETHYL-O-[2-ISOPROPYL-4-METHYL-6-PYRIMIDYL]PHOSPHOROTHIOATE
  • O,O-DIETHYL-O-(2-ISOPROPYL)-(4-METHYL-6-PYRIMIDYL)THIOPHOSPHATE
  • O,O-DIETHYL O-(2-ISOPROPYL-6-METHYL-4-PYRIMIDINYL)PHOSPHOROTHIOATE
  • O,O-Diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) phosophorothioate
  • NEOCIDOL
  • ALFA-TOX(R)
  • NUCIDOL(R)
  • SPECTACIDE(R)
  • SAROLEX(R)
  • BASUDIN
  • BASUDIN(R)
  • CEKUZINON
  • Dazzel,DBD
  • DIAZOL
  • DIAZINON
  • DIANON
  • DIANOZYL
  • G 24480(R)
  • Anti-SF3b10
  • Anti-SF3B5 (1-15) antibody produced in rabbit
  • Anti-Splicing factor 3b, subunit 5, 10kDa
  • Anti-MGC117302
  • Anti-MGC125802
  • チオりん酸=O-(2-イソプロピル-6-メチル-4-ピリミジニル)=O,O-ジエチル
  • バスジン
  • ジアジノン
  • ダイアジノン
  • スペクトラシド
  • チオりん酸O,O-ジエチルO-(2-イソプロピル-6-メチル-4-ピリミジニル)
  • チオりん酸O,O-ジエチル-O-(2-イソプロピル-6-メチル-4-ピリミジニル)
  • ネオシドール
  • ジムピラート
  • サロレックス
  • ホスホロチオ酸O,O-ジエチルO-(2-イソプロピル-6-メチルピリミジン-4-イル)
  • ヌシドール
  • ジアジトール
  • スペクトラシード
  • ダイアジトール
  • ダイアジノン標準液
  • ダイアジノン標準品
  • O,O-ジエチルO-(2-イソプロピル-6-メチルピリジン-4-イル)ホスホロチオアート
  • 2-イソプロピル-4-メチルピリミジル-6-ジエチルチオホスフェイト
  • チオりん酸O,O-ジエチル-O-(2-イソプロピル-6-メチル-4-ピリミジニル) (別名 ダイアジノン)
  • CS_N-11621-250MG_ダイアジノン-O-アナログ
  • ダイアジノン STANDARD
  • ダイアジノン標準物質
  • ダイアジノン Standard, 100 µg/mL in MeOH
  • ダイアジノン Standard, 1000 µg/mL in Hexane
  • ダイアジノン Standard, 1000 µg/mL in MeOH
  • コリンエステラーゼ阻害剤
  • 防疫用殺虫剤
  • 有機リン系殺虫剤
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