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ジフェンヒドラミン 塩酸塩

ジフェンヒドラミン  塩酸塩 化学構造式
147-24-0
CAS番号.
147-24-0
化学名:
ジフェンヒドラミン 塩酸塩
别名:
ジフェンヒドラミン 塩酸塩;塩酸ジフェンヒドラミン;ジメドロール;ベナ;ジフェンヒドラミン塩酸塩;N,N-ジメチル-2-(ジフェニルメトキシ)エタンアミン·塩酸塩;2-(α-フェニルベンジルオキシ)エチルジメチルアミン·塩酸塩;レスタミン;2-(ジフェニルメトキシ)-N,N-ジメチルエタンアミン·塩酸塩;ベナスミン;ドリエル;レスミン;ベナドリル;2-ジフェニルメトキシ-N,N-ジメチルエタナミン塩酸塩;2-(ベンズヒドリルオキシ)-N,N-ジメチルエチルアミン塩酸塩;2-ジフェニルメトキシ-N,N-ジメチルエチルアミン塩酸塩;ジフェンヒドラミンHCL;2-(ジフェニルメトキシ)-N,N-ジメチルエチルアミン塩酸塩;N,N-ジメチル-2-(ジフェニルメトキシ)エチルアミン塩酸塩;ジフェンヒドラミン 塩酸塩
英語化学名:
Diphenhydramine Hydrochloride
英語别名:
BAX;Contac;Felben;Resmin;BCL2L4;Ambenyl;Actifed;Benylin;Prodryl;Rohydra
CBNumber:
CB7709166
化学式:
C17H22ClNO
分子量:
291.82
MOL File:
147-24-0.mol

ジフェンヒドラミン 塩酸塩 物理性質

融点 :
168-172 °C
沸点 :
163-167 °C(Press: 3 Torr)
比重(密度) :
1.0489 (rough estimate)
屈折率 :
1.5800 (estimate)
闪点 :
9℃
貯蔵温度 :
2-8°C
溶解性:
Very soluble in water, freely soluble in alcohol.
外見 :
Crystalline Powder or Adhering Crystals
色:
White
PH:
pH(100g/L, 25℃) 4.0~5.5
水溶解度 :
1000 g/L
Sensitive :
Light Sensitive
Merck :
14,3309
安定性::
Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.
InChIKey:
PCHPORCSPXIHLZ-UHFFFAOYSA-N
CAS データベース:
147-24-0(CAS DataBase Reference)
NISTの化学物質情報:
diphenhydramine hydrochloride(147-24-0)
EPAの化学物質情報:
Diphenhydramine hydrochloride (147-24-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,T,F
Rフレーズ  22-39/23/24/25-23/24/25-11
Sフレーズ  36-45-36/37-16-7-24/25
RIDADR  2811
WGK Germany  3
RTECS 番号 KR7000000
HSコード  29221990
毒性 LD50 orally in rats: 500 mg/kg (Gruhzit, Fisken)
化審法 (9)-484, (9)-690
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P311 医師に連絡すること。
P330 口をすすぐこと。
P501 内容物/容器を...に廃棄すること。

ジフェンヒドラミン 塩酸塩 価格 もっと(36)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC358131
[2-(diphenylmethoxy)ethyl]dimethylamine hydrochloride
147-24-0 25g ¥16900 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC358131
[2-(diphenylmethoxy)ethyl]dimethylamine hydrochloride
147-24-0 500g ¥138100 2021-03-23 購入
東京化成工業 D0423 ジフェンヒドラミン塩酸塩 >98.0%(HPLC)(T)
Diphenhydramine Hydrochloride >98.0%(HPLC)(T)
147-24-0 500g ¥32700 2021-03-23 購入
東京化成工業 D0423 ジフェンヒドラミン塩酸塩 >98.0%(HPLC)(T)
Diphenhydramine Hydrochloride >98.0%(HPLC)(T)
147-24-0 25g ¥4300 2021-03-23 購入
関東化学株式会社(KANTO) 10560-32 ジフェンヒドラミン塩酸塩 >97.0%
Diphenhydramine hydrochloride >97.0%
147-24-0 25g ¥3900 2021-03-23 購入

ジフェンヒドラミン 塩酸塩 MSDS


N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

ジフェンヒドラミン 塩酸塩 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、ジフェニルメトキシジメチルエタノールアミンの塩酸塩であり、次の化学式で表される。

溶解性

酢酸に極めて溶けやすく、水及びエタノールに溶けやすく、アセトンにやや溶けにくく、ジエチルエーテルにほとんど溶けない。水:1g/ml、エタノール:1g/2ml、アセトン:1g/50ml。氷酢酸, メタノールに極めて易溶。

用途

神経化学研究用。

用途

ジフェンヒドラミン誘導体で す。抗ヒスタミン作用及びケミカルメディ エーター遊離抑制作用を示します。

用途

抗アレルギー剤、抗ヒスタミン剤

化粧品の成分用途

ヘアコンディショニング剤、外用鎮痛剤、薬用収れん剤-皮膚防御剤

効能

抗アレルギー薬, H1受容体拮抗薬

商品名

ジフェンヒドラミン塩酸塩 (日新製薬-山形); レスタミン (興和)

化学的特性

White or almost white, crystalline powder.

Originator

Benadryl,Parke Davis,US,1946

使用

H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic

使用

Diphenhydramine hydrochloride is used as an antihistamine and for its antieholinergie (drying) and sedative effects; for allergic conjunctivitis due to foods; for mild, uncomplicated allergic skin manifestations of urticaria and angioedema; for amelioration of allergic reactions to blood or plasma; for dermatographism; in therapy for anaphylaetie reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; for active and prophylactie treatment of motion sickness; for parkinsonism; an antiemetic; has local anesthetic properties; in preparations for the relief of cough; in the prevention and treatment of radiation sickness, nausea and vomiting; for treatment of allergie cheilitis and stomatitis.

使用

Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.

使用

antihistamine, sedative, treatment of allergic

使用

A histamine H1-receptor antagonist.

定義

ChEBI: The hydrochloride salt of diphenhydramine.

Manufacturing Process

As described in US Patent 2,421,714: (a) benzhydryl
omide is first prepared as follows: 840 parts by weight of diphenylmethane is heated to 130°C with stirring. In the presence of a 200 watt electric light 6 inches from the flask, 880 parts of
omine is added slowly. Liberation of H
occurs and addition requires 1 hour and 45 minutes. The temperature is maintained at 130°C for an additional 30 minutes. A fine stream of air is blown in to remove H
and
2 while the reaction mixture cools. Benzene (180 parts) is added and the solution used immediately in (b) below.
If pure benzhydryl
omide is desired the above reaction mixture is dissolved in ether, washed with water, sodium carbonate solution and finally with water. The ether is removed, benzene added and distilled off and the benzhydryl
omide distilled in vacuo. Yield 85%.
(b) 490 parts β-dimethylaminoethanol and 530 parts of anhydrous sodium carbonate are heated to 110°C with stirring. The addition of the benzenebenzhydryl
omide mixture is then begun. The temperature is raised to 120°- 125°C. As reaction takes place carbon dioxide is evolved, the addition requires1? hours. The mixture is kept at 125°C for 5 hours additional time. After cooling, 3,000 parts of water is added and the mixture stirred until the inorganic salts are dissolved. The mixture is transferred to a large separatory funnel and 1,500 parts of ether added. The ether solution is washed several times with water and then the ether layer extracted with 1 to 4 hydrochloric acid. The acid solution is treated with 30 parts of Darco and 30 parts Filter-Cel and filtered.
The free base is liberated from the acid solution with 20% sodium hydroxide solution and taken up in ether. The ether layer is washed with water, saturated with NaCl and then shaken with solid potassium hydroxide. The ether is removed by distillation, 200 parts of benzene added and distilled off. The residue is distilled in vacuo and the fraction 150°-165°C/2 mm is collected and amounts to 433 parts. The hydrochloride salt is prepared by dissolving the free base in anhydrous ether and slowly adding an alcoholic solution of hydrogen chloride. The solid is recrystallized from absolute alcohol-ether mixture or isopropanol-ether mixture and has a MP of 161-162°C.

brand name

Benadryl (Parke-Davis).

Therapeutic Function

Antihistaminic

一般的な説明

Diphenhydramine hydrochloride, 2-(diphenylmethoxy)- N,N-dimethylethanamine hydrochloride (Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, white crystalline powder soluble in water (1:1), alcohol (1:2) and chloroform (1:2). The salt has a pKa value of 9, and a 1% aqueous solution has a pH of about 5.
In addition to antihistaminic action, diphenhydramine exhibits antidyskinetic, antiemetic, antitussive and antimuscarinic, and sedative properties.As an antihistaminic agent, diphenhydramine is recommended in various allergic conditions and, to a lesser as an antitussive and Parkinsonism drug. It is also used in OTC sleep-aid products. It is administered either orally or parenterally in the treatment of urticaria, seasonal rhinitis (hay fever), and some dermatoses.

一般的な説明

White or almost-white crystalline powder. Odorless with a bitter numbing taste. pH (5% aqueous solution) 4-6.

空気と水の反応

Water soluble. Aqueous solutions are acidic.

反応プロフィール

N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

火災危険

Flash point data for N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride are not available; however, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride is probably combustible.

生物活性

H 1 receptor antagonist. Antihistamine.

接触アレルゲン

This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.

安全性プロファイル

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also ESTERS and ETHERS.

Veterinary Drugs and Treatments

In veterinary medicine, diphenhydramine is used principally for its antihistaminic effects, but also for other pharmacologic actions. Its sedative effects can be of benefit in treating the agitation (pruritus, etc.) associated with allergic responses. It has also been used for treatment and prevention of motion sickness and as an antiemetic in small animals. It has been suggested for use as adjunctive treatment of aseptic laminitis in cattle and it may be useful as an adjunctive treatment for feline pancreatitis. For other suggested uses, refer to the Dosage section below.

ジフェンヒドラミン 塩酸塩 上流と下流の製品情報

原材料

準備製品


ジフェンヒドラミン 塩酸塩 生産企業

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147-24-0(ジフェンヒドラミン 塩酸塩)キーワード:


  • 147-24-0
  • 2-(diphenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride
  • 2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride
  • Actifed
  • alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride
  • alpha-hydroxydiphenylmethane-beta-dimethylaminoethyletherhydrochloride
  • Ambenyl
  • BAX
  • Benacine
  • Benadril hydrochloride
  • Benadryl hydrochloride
  • Bena-fedrin
  • Bendylate
  • Benocten
  • Benylin
  • Benzantin
  • Benzantin hydrochloride
  • Benzehist
  • benzhydrol,beta-dimethylaminoethyletherhydrochloride
  • beta-Dimethylaminoethyl benzhydryl ether hydrochloride
  • beta-dimethylaminoethylbenzhydryletherhydrochloride
  • Carphenamine
  • Carphenex
  • Cathejell
  • component of Benacine
  • component of Bena-Fedrin
  • component of Caladryl
  • Contac
  • Denydryl
  • Difenhydramine hydrochloride
  • difenhydraminehydrochloride
  • ジフェンヒドラミン 塩酸塩
  • 塩酸ジフェンヒドラミン
  • ジメドロール
  • ベナ
  • ジフェンヒドラミン塩酸塩
  • N,N-ジメチル-2-(ジフェニルメトキシ)エタンアミン·塩酸塩
  • 2-(α-フェニルベンジルオキシ)エチルジメチルアミン·塩酸塩
  • レスタミン
  • 2-(ジフェニルメトキシ)-N,N-ジメチルエタンアミン·塩酸塩
  • ベナスミン
  • ドリエル
  • レスミン
  • ベナドリル
  • 2-ジフェニルメトキシ-N,N-ジメチルエタナミン塩酸塩
  • 2-(ベンズヒドリルオキシ)-N,N-ジメチルエチルアミン塩酸塩
  • 2-ジフェニルメトキシ-N,N-ジメチルエチルアミン塩酸塩
  • ジフェンヒドラミンHCL
  • 2-(ジフェニルメトキシ)-N,N-ジメチルエチルアミン塩酸塩
  • N,N-ジメチル-2-(ジフェニルメトキシ)エチルアミン塩酸塩
  • ジフェンヒドラミン 塩酸塩
  • ジフェンヒドラミン塩酸塩 (JP17)
  • 抗ヒスタミン薬成分
  • 生化学
  • 薬理研究用試薬
  • ヒスタミンH1受容体遮断薬
  • 鎮痒剤
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