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m-クレゾール

m-クレゾール 化学構造式
108-39-4
CAS番号.
108-39-4
化学名:
m-クレゾール
别名:
m-クレゾール;m-メチルフェノール;m-クレソール;m-クレシル酸;3-メチルフェノール;m-トルオール;メタクレゾール;m-ヒドロキシトルエン;m-クレゾル;mクレゾール;mクレゾル;M‐クレゾール;M-クレゾール標準品;M-クレゾール 5000ΜG/ML IN METHANOL;M-クレゾール STANDARD;3-メチルフェノール 溶液;m - クレゾール;m-クレゾール Standard, 100 µg/mL in Dichloromethane;m-クレゾール Standard, 1000 µg/mL in Dichloromethane;m-クレゾール Standard, 5.0 mg/mL in MeOH
英語化学名:
m-Cresol
英語别名:
m-Cesol;m-Kresol;m-Toluol;3-Cresol;M-CRESOL;m-Cresole;FEMA 3530;M-CresolGr;KRESOL-META;M-CRESOL 70
CBNumber:
CB7852747
化学式:
C7H8O
分子量:
108.14
MOL File:
108-39-4.mol

m-クレゾール 物理性質

融点 :
8-10 °C(lit.)
沸点 :
203 °C(lit.)
比重(密度) :
1.034 g/mL at 25 °C(lit.)
蒸気密度:
3.72 (vs air)
蒸気圧:
<1 mm Hg ( 20 °C)
FEMA :
3530 | M-CRESOL
屈折率 :
n20/D 1.541(lit.)
闪点 :
187 °F
貯蔵温度 :
2-8°C
溶解性:
23.5g/l
外見 :
Liquid
酸解離定数(Pka):
10.01(at 25℃)
色:
Clear colorless to slight red
PH:
5 (20g/l, H2O, 20℃)
臭気閾値(Odor Threshold):
0.0001ppm
爆発限界(explosive limit):
1.06-1.35%, 150°F
水溶解度 :
20 g/L (20 ºC)
極大吸収波長 (λmax):
273nm(lit.)
JECFA Number:
692
Merck :
14,2579
BRN :
506719
安定性::
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, strong acids, aluminium, aluminium alloys. Air and light sensitive. Hygroscopic.
CAS データベース:
108-39-4(CAS DataBase Reference)
NISTの化学物質情報:
Phenol, 3-methyl-(108-39-4)
EPAの化学物質情報:
m-Cresol (108-39-4)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  24/25-34-39/23/24/25-23/24/25
Sフレーズ  36/37/39-45-36/37
RIDADR  UN 2076 6.1/PG 2
WGK Germany  1
RTECS 番号 GO6125000
8
自然発火温度 626 °C
TSCA  Yes
国連危険物分類  6.1
容器等級  II
HSコード  29071200
有毒物質データの 108-39-4(Hazardous Substances Data)
毒性 LD50 orally in rats: 2.02 g/kg (Deichmann, Witherup)
消防法 危険物第4類第三石油類(非水溶性)
化審法 (3)-499, (4)-57 優先評価化学物質
安衛法 有機則 第二種有機溶剤等
PRTR法 第一種指定化学物質
毒劇物取締法 劇物
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H225 引火性の高い液体および蒸気 引火性液体 2 危険 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H227 引火性液体 引火性液体 4 警告 P210, P280, P370+P378, P403+P235,P501
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 重篤な眼の損傷 眼に対する重篤な損傷性/眼刺激 性 1 危険 P280, P305+P351+P338, P310
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H370 臓器の障害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P307+P311, P321,P405, P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H373 長期にわたる、または反復暴露により臓器の障 害のおそれ 特定標的臓器有害性、単回暴露 2 警告 P260, P314, P501
H401 水生生物に毒性 水生環境有害性、急性毒性 2 P273, P501
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P310 ただちに医師に連絡すること。

m-クレゾール 価格 もっと(31)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSAPP-9-050 m-クレゾール Standard
m-Cresol Standard, 100 ug/mL in Dichloromethane
108-39-4 1mL ¥4400 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSAPP-9-050-10X m-クレゾール Standard
m-Cresol Standard, 1000 ug/mL in Dichloromethane
108-39-4 1mL ¥5500 2018-12-26 購入
東京化成工業 C0401 m-クレゾール >98.0%(GC)
m-Cresol >98.0%(GC)
108-39-4 500g ¥5900 2018-12-04 購入
東京化成工業 C0401 m-クレゾール >98.0%(GC)
m-Cresol >98.0%(GC)
108-39-4 25g ¥2000 2018-12-04 購入
関東化学株式会社(KANTO) 07454-00 m‐クレゾール >98.0%(GC)
m‐Cresol >98.0%(GC)
108-39-4 500mL ¥5600 2018-12-13 購入

m-クレゾール MSDS


m-Cresol

m-クレゾール 化学特性,用途語,生産方法

外観

無色〜褐色, 澄明の液体

溶解性

水, エタノール, エーテルに可溶。エタノールに極めて溶けやすく、水にやや溶けにくい。

用途

水質試験用

用途

防腐剤、消毒剤

効能

抗真菌薬, 外用消毒薬

使用上の注意

不活性ガス封入

化学的特性

colourless to light yellow liquid

化学的特性

Cresol is a mixture of the three isomeric cresols, o-, m-, and p-cresol. Cresols are slightly soluble in water. m-Isomer: Colorless or yellow liquid with characteristic odor.

化学的特性

m-Cresol has a dry, tarry, medicinal–leathery odor. m-Cresol and p-cresol very often occur together and are difficult to separate.

天然物の起源

Reported found in beer, coffee, egg, grape, Oriental tobacco, roasted barley, rum, sherry and whiskey.

使用

m-Cresol is used as a disinfectant and solvent. LysolTM disinfectant is a 50% (v/v) mixed-cresol isomer in a soap emulsion formed on mixing with water. The isomer m-cresol is an oily liquid with low volatility. Besides disinfection at solutions of 1–5%, the cresols are used in degreasing compounds, paintbrush cleaners, and additives in lubricating oils. Cresols were once widely used for disinfection of poultry houses, but this use has been discontinued because they cause respiratory problems and abdominal edema in young chicks. m-Cresol has been used in synthetic resins, explosives, petroleum, photographic, paint, and agricultural industries.

使用

Antiseptic; antimicrobial preservative.

定義

ChEBI: A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.

調製方法

The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. m-Cresol is prepared from m-toluic acid or obtained from coal tar or petroleum (352, 355, 356). Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ~180–201°C. The m-cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluidine or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

製造方法

One process involving butylation and separation and followed by dealkylation produces m-cresol and ditertiary butyl p-cresol. From m, p-cresol (which is the main product of the recovery process) pure m-cresol can be obtained by extraction.

Aroma threshold values

Aroma characteristics at 1.0%: phenolic, spicy eugenol-like, medicinal, smoky powdery with a leatherlike note.

Taste threshold values

Taste characteristics at 2 ppm: phenolic, smoky, balsamic, medicinal and spicy eugenol-like

一般的な説明

Colorless liquid with a sweet tarry odor. Sinks and mixes slowly with water.

空気と水の反応

Water soluble.

反応プロフィール

m-Cresol is sensitive to air, light and heat. m-Cresol is also hygroscopic. m-Cresol can react vigorously with strong oxidizers and strong bases. m-Cresol reacts violently with nitric acid, oleum, chlorosulfonic acid, metals and strong acids. If the water content is below approximately 0.3% and the temperature above 248° F, the corrosion of aluminum and its alloys may occur violently. m-Cresol will attack some forms of plastics, coatings and rubber.

危険性

Questionable carcinogen.

健康ハザード

INHALATION: Mucosal irritation and systemic poisoning EYES: Intense irritation and pain, swelling of conjunctiva, and corneal damage may occur. SKIN: Intense burning, loss of feeling, wrinkling, white discoloration, and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Acute exposure by all routes may cause muscular weakness, gastroenteric disturbances, severe depression, collapse. Effects are primarily on CNS and edema of lungs. Injury of spleen and pancreas may occur.

接触アレルゲン

Metacresol is contained as a preservative in almost all human insulin. It has been reported as a cause of allergic reaction due to injected insulin.

安全性プロファイル

v Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by skin contact. Severe eye and skin irritant. An experimental teratogen. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. Flammable when exposed to heat or flame. Moderately explosive in the form of vapor when exposed to heat or flame. See also other cresol entries and PHENOL.

職業ばく露

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

Carcinogenicity

m-Cresol has induced a few papillomas but no carcinomas in tumor studies.

輸送方法

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

純化方法

Separation of the m-and p-cresols requires chemical methods, such as conversion to their sulfonates [Brüchner Anal Chem 75 289 1928]. An equal volume of H2SO4 is added to m-cresol, stirred with a glass rod until solution is complete. Heat for 3hours at 103-105o. Dilute carefully with 1-1.5 volumes of water, heat to boiling point and steam distil until all unsulfonated cresol has been removed. Cool and extract the residue with ether. Evaporate the solution until the boiling point reaches 134o and steam distil off the m-cresol. Another purification method involves distillation, fractional crystallisation from the melt, then redistillation. Free from p-cresol by solution in glacial acetic acid and bromination by about half of an equivalent amount of bromine in glacial acetic acid. The acetic acid is distilled off, then fractional distillation of the residue under vacuum gives bromocresols from which 4-bromo-m-cresol is obtained by crystallisation from hexane. Addition of the bromocresol in glacial acetic acid slowly to a reaction mixture of HI and red phosphorus or (more smoothly) of HI and hypophosphorus acid, in glacial acetic acid, at reflux, removes the bromine. After an hour, the solution is distilled at atmospheric pressure until layers are formed. Then it is cooled and diluted with water. The cresol is extracted with ether, washed with water, NaHCO3 solution and again with water, dried with a little CaCl2 and distilled [Baltzly et al. J Am Chem Soc 77 2522 1955]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 165o. [Beilstein 6 IV 2035.]

不和合性

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

廃棄物の処理

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

m-クレゾール 上流と下流の製品情報

原材料

準備製品


m-クレゾール 生産企業

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108-39-4(m-クレゾール)キーワード:


  • 108-39-4
  • m-CresolUSPXXIII
  • m-Cresylic acid
  • m-cresylicacid
  • meta-cresolsaka3-methylphenol
  • meta-cresylicacid
  • m-Kresol
  • m-Oxytoluene
  • m-Toluol
  • Phenol,3-methyl-
  • rover’sdogshampoo
  • M-CresolGr
  • m-Cresol, 99+%
  • m-Cresol, USP
  • m-Cesol
  • m-cresol,3-methyl-phenol
  • 3-methylphenol solution
  • M-CRESOL,HIGHPURITY
  • META-METHYLPHENOL
  • META-OXYTOLUENE
  • KRESOL-META
  • m-CRESOL extrapure
  • m-CRESOL pure
  • 3-Methylphenol, m-Cresol solution
  • 3-Methylphenol, m-Cresol
  • 2-Oxo-5-methyl-2,3-dihydrofuran
  • 5-Methyl-2,3-dihydro-2-furanone
  • g-Angelica lactone
  • m-Cresol Standard
  • m-Cresol, synthesis grade
  • m-Cresol, reagent grade
  • m-クレゾール
  • m-メチルフェノール
  • m-クレソール
  • m-クレシル酸
  • 3-メチルフェノール
  • m-トルオール
  • メタクレゾール
  • m-ヒドロキシトルエン
  • m-クレゾル
  • mクレゾール
  • mクレゾル
  • M‐クレゾール
  • M-クレゾール標準品
  • M-クレゾール 5000ΜG/ML IN METHANOL
  • M-クレゾール STANDARD
  • 3-メチルフェノール 溶液
  • m - クレゾール
  • m-クレゾール Standard, 100 µg/mL in Dichloromethane
  • m-クレゾール Standard, 1000 µg/mL in Dichloromethane
  • m-クレゾール Standard, 5.0 mg/mL in MeOH
  • m-クレゾール, 99%
  • 3-クレゾール
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