エチルバニリン 化学特性,用途語,生産方法
外観
白色～うすい黄褐色、結晶性粉末～粉末
定義
本品は、次の化学式であらわされるフェノール誘導体である。
製造法
そのほか，オイゲノールまたはサフロールを原料とする方法もある。［エチルバニリンethyl vanillin］ バニリン分子内の－OCH3基の代りに－OC2H5基が入ったものが合成され，バニリンと同様の芳香をもち，かつその強さも強いことが見いだされた。これをエチルバニリン，またはブルボナールbourbonalという。株式会社平凡社 世界大百科事典 第２版について | 情報
化粧品の成分用途
酸化防止剤、香料、香味剤
効能
香料
使用上の注意
アルゴン封入
化学的特性
Ethyl vanillin has an intense vanilla odor and sweet taste. The flavoring power is two to four times stronger than vanillin. Ethyl vanillin has been used in food since the 1930s; it enhances fruity and chocolate odor impression. Its addition is self-limiting,
as too high a level may impart an unpleasant flavor in the product; the product is not stable. In contact with iron or alkali, it exhibits
a red color and loses its flavoring power.
天然物の起源
Not reported found in nature; it can be distinguished from vanillin because of the yellow color developed in
the presence of concentrated H2SO4.
使用
Ethyl Vanillin is a flavoring agent that is a synthetic vanilla flavor
with approximately three and one-half times the flavoring power of
vanillin. it has a solubility of 1 g in 100 ml of water at 50°c. it is
used in ice cream, beverages, and baked goods.
定義
ChEBI: A member of the class of benzaldehydes that is vanillin in which the methoxy group is replaced by an ethoxy group.
調製方法
Unlike vanillin, ethyl vanillin does not occur naturally. It may be
prepared synthetically by the same methods as vanillin, using
guethol instead of guaiacol as a starting material; see Vanillin.
製造方法
From safrole by isomerization to isosafrole and subsequent oxidation to piperonal; the methylene linkage is then broken
by heating piperonal in an alcoholic solution of KOH; finally the resulting protocatechualdehyde is reacted with ethyl alcohol. From
guaethol by condensation with chloral to yield 3-ethoxy-4-hydroxyphenyl trichloromethyl carbinol; this is then boiled with an alcoholic solution of KOH or NaOH, acidified, and extracted with chloroform to yield ethyl vanillin.
一般的な説明
Colorless crystals. More intense vanilla odor and taste than vanillin.
空気と水の反応
Slightly water soluble .
反応プロフィール
Protect from light. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). The addition of stabilizers (antioxidants) to shipments of aldehydes retards autoxidation.
健康ハザード
ACUTE/CHRONIC HAZARDS: Toxic. May cause irritation on contact.
火災危険
Combustible
応用例（製薬）
Ethyl vanillin is used as an alternative to vanillin, i.e. as a flavoring
agent in foods, beverages, confectionery, and pharmaceuticals. It is
also used in perfumery.
Ethyl vanillin possesses a flavor and odor approximately three
times as intense as vanillin; hence the quantity of material necessary
to produce an equivalent vanilla flavor may be reduced, causing less
discoloration to a formulation and potential savings in material
costs. However, exceeding certain concentration limits may impart
an unpleasant, slightly bitter taste to a product due to the intensity
of the ethyl vanillin flavor.
安全性プロファイル
Moderately toxic by
ingestion, intraperitoneal, subcutaneous, and
intravenous routes. A human skin irritant.
Mutation data reported. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also ALDEHYDES and ETHERS.
安全性
Ethyl vanillin is generally regarded as an essentially nontoxic and
nonirritant material. However, cross-sensitization with other
structurally similar molecules may occur.
The WHO has allocated an acceptable daily intake for ethyl
vanillin of up to 3 mg/kg body-weight.
LD50 (guinea pig, IP): 1.14 g/kg
LD50 (mouse, IP): 0.75 g/kg
LD50 (rabbit, oral): 3 g/kg
LD50 (rabbit, SC): 2.5 g/kg
LD50 (rat, oral): 1.59 g/kg
LD50 (rat, SC): 3.5–4.0 g/kg
貯蔵
Store in a well-closed container, protected from light, in a cool, dry
place. See Vanillin for further information.
不和合性
Ethyl vanillin is unstable in contact with iron or steel, forming a redcolored, flavorless compound. In aqueous media with neomycin sulfate or succinylsulfathiazole, tablets of ethyl vanillin produced a yellow color. See Vanillin for other potential incompatibilities.
規制状況(Regulatory Status)
GRAS listed. Included in the FDA Inactive Ingredients Database
(oral capsules, suspensions, and syrups). Included in nonparenteral
medicines licensed in the UK.
エチルバニリン 上流と下流の製品情報
原材料
準備製品