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フェノペリジン

フェノペリジン 化学構造式
562-26-5
CAS番号.
562-26-5
化学名:
フェノペリジン
别名:
1-(3-ヒドロキシ-3-フェニルプロピル)-4-フェニル-4-ピペリジンカルボン酸エチル;1-(3-ヒドロキシ-3-フェニルプロピル)-4-フェニルピペリジン-4-カルボン酸エチル;フェノペリジン
英語化学名:
phenoperidine
英語别名:
phenoperidine;IPOPQVVNCFQFRK-UHFFFAOYSA-N;ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate;1-(3-Hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester;4-Piperidinecarboxylic acid, 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-, ethyl ester
CBNumber:
CB7930605
化学式:
C23H29NO3
分子量:
367.48
MOL File:
562-26-5.mol

フェノペリジン 物理性質

沸点 :
508.8±50.0 °C(Predicted)
比重(密度) :
1.122±0.06 g/cm3(Predicted)
酸解離定数(Pka):
14.31±0.20(Predicted)

安全性情報

RIDADR  3249
国連危険物分類  6.1(b)
容器等級  III

フェノペリジン 価格

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フェノペリジン 化学特性,用途語,生産方法

効能

麻酔薬, 麻薬性鎮痛薬

Originator

Operidine ,Janssen ,US ,1965

Manufacturing Process

The starting materials for the overall process are phenylacetonitrile with bischloroethyl toluene sulfonyl amide. These react to give a product which hydrolyzes to normeperidine (4-carboethoxy-4-phenylpiperidine). Condensation of that material with benzoylethylene gives the ketone: β-(4carboethoxy-4-phenylpiperidino)propiophenone.
A reaction mixture was prepared containing 4 grams of β-(4-carboethoxy-4phenylpiperidino)-propiophenone hydrochloride, 100 ml of methanol and about 0.5 gram of platinum oxide catalyst. The mixture was placed in a low pressure hydrogenation apparatus and was hydrogenated at a temperature of about 27°C and a pressure of about 3.5 atmospheres of hydrogen to convert the keto group of the β-(4-carboethoxy-4-phenylpiperidino)-propiophenone to a hydroxy group, and to form 3-(4-carboethoxy-4-phenylpiperidino)-1-phenyl-1propanol hydrochloride. After the hydrogenation was complete, the catalyst was separated from the reaction mixture by filtration, and the filtrate was evaporated to dryness in vacuo leaving a residue containing 3-(4carboethoxy-4-phenylpiperidino)-1-phenyl-l-propanol hydrochloride. The residue was digested with ethyl acetate thereby causing 3-(4-carboethoxy-4phenylpiperidino)-1-phenyl-1-propanol hydrochloride to crystallize. This compound melted at about 188°-189°C after being recrystallized three times from an ethyl acetate-methanol solvent mixture, according to US Patent 2,951,080.

Therapeutic Function

Analgesic

フェノペリジン 上流と下流の製品情報

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562-26-5(フェノペリジン)キーワード:


  • 562-26-5
  • phenoperidine
  • 1-(3-Hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester
  • IPOPQVVNCFQFRK-UHFFFAOYSA-N
  • ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate
  • 4-Piperidinecarboxylic acid, 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-, ethyl ester
  • 1-(3-ヒドロキシ-3-フェニルプロピル)-4-フェニル-4-ピペリジンカルボン酸エチル
  • 1-(3-ヒドロキシ-3-フェニルプロピル)-4-フェニルピペリジン-4-カルボン酸エチル
  • フェノペリジン
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