イバブラジン塩酸塩
イバブラジン塩酸塩 物理性質
- 融点 :
- 193-196?C
- 比旋光度 :
- 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- H2O: ≥5mg/mL (加温)
- 外見 :
- 粉
- 色:
- 白からベージュ
- 光学活性 (optical activity):
- [α]/D +5 to +9°, c = 1 in DMSO
- Merck :
- 14,5247
- InChIKey:
- HLUKNZUABFFNQS-ZMBIFBSDSA-N
- SMILES:
- C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
- CAS データベース:
- 148849-67-6(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
主な危険性 |
N |
|
|
Rフレーズ |
50/53 |
|
|
Sフレーズ |
60-61 |
|
|
RIDADR |
UN 3077 9 / PGIII |
|
|
WGK Germany |
3 |
|
|
HSコード |
2933.79.1500 |
|
|
絵表示(GHS) |
|
注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H400 |
水生生物に強い毒性 |
水生環境有害性、急性毒性 |
1 |
警告 |
|
P273, P391, P501 |
|
注意書き |
|
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS093576 |
イバブラジン塩酸塩
Ivabradine hydrochloride |
148849-67-6 |
250mg |
¥341300 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01MAS093576 |
イバブラジン塩酸塩
Ivabradine hydrochloride |
148849-67-6 |
1g |
¥757600 |
2024-03-01 |
購入 |
東京化成工業
|
I0847 |
イバブラジン塩酸塩 >98.0%(HPLC)(N)
Ivabradine Hydrochloride
>98.0%(HPLC)(N) |
148849-67-6 |
200mg |
¥19100 |
2023-06-01 |
購入 |
東京化成工業
|
I0847 |
イバブラジン塩酸塩 >98.0%(HPLC)(N)
Ivabradine Hydrochloride
>98.0%(HPLC)(N) |
148849-67-6 |
1g |
¥63100 |
2023-06-01 |
購入 |
Sigma-Aldrich Japan
|
SML0281 |
イバブラジン 塩酸塩 ≥98% (HPLC)
Ivabradine hydrochloride ≥98% (HPLC) |
148849-67-6 |
10mg |
¥23700 |
2024-03-01 |
購入 |
イバブラジン塩酸塩 化学特性,用途語,生産方法
外観
白色~わずかにうすい褐色、結晶性粉末~粉末
用途
If チャンネル阻害剤です。心
臓の収縮機能や血圧に影響を及ぼすさず、心
拍数を低下させます。
効能
強心薬
説明
In an effort to develop angina agents without the unwanted negative
inotropic and hypotensive effects associated with b-adrenergic blockers and
calcium channel blockers, a new class of heart-rate reducing compounds that act
specifically on the sinoatrial (SA) node has been explored. These bradycardic
agents interact directly with the pacemaking cell of the SA node and the hyperpolarization-
activated If , the primary pacemaking current. Ivabradine has
evolved as a specific inhibitor of If current through its contact with f-channels on
the intracellular side of the plasma membrane. As a consequence, ivabradine
reduces the speed of diastolic depolarization and decreases heart rate. It has been
approved for the treatment of chronic stable angina and provides a viable
alternative to patients with a contraindication or intolerance of b-blockers. Evaluation
is also underway for the potential treatment of ischemic heart disease.
Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If
current ranged from 6% (0.03 mM) – 80% (10 mM).
.
化学的特性
White to Off-White Solid
使用
Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).
定義
ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
イバブラジン塩酸塩 上流と下流の製品情報
原材料
3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride
3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
準備製品
イバブラジン塩酸塩 生産企業
Global( 449)Suppliers
イバブラジン塩酸塩 スペクトルデータ(1HNMR)
148849-67-6(イバブラジン塩酸塩)キーワード:
- 148849-67-6
- Ivabradine hydrochloride
- 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
- Ivabradine hydrochloride, >=99%
- IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR
- 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
- Corlentor
- S-16257
- (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride
- 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
- 2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)-
- Ivabridine hydracloride
- 2H-3-Benzazepin-2-one,3-[3-[[[(7S)-3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-,hydrochloride (1:1)
- 3-[3-[[(3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-, Monohydrochloride
- 2H-3-Benzazepin-2-on
- Ivabradine HCl (Procoralan)
- (S)-3-(3-(((3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl)(Methyl)aMino)propyl)-7,8-diMethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
- S 16257-2
- 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride (1:1)
- Ivabradine hydrochloride, 98%, a If inhibitor
- lvabradine hydrochloride
- CS-774
- IvabradineHydrochloride>
- Ivabradine hydrochloride USP/EP/BP
- Ivabradine Hydrochloride Impurities
- (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
- Ivabradine HydrochlorideQ: What is
Ivabradine Hydrochloride Q: What is the CAS Number of
Ivabradine Hydrochloride Q: What is the storage condition of
Ivabradine Hydrochloride Q: What are the applications of
Ivabradine Hydrochloride
- Ivabradine HCl
- Procoralan
- Ivabradine hydrochlorid
- 2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-,(6E)-
- イバブラジン塩酸塩
- イバブラジン塩酸塩 (JAN)