ビラスチン
ビラスチン 物理性質
- 融点 :
- 202 °C
- 沸点 :
- 639.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.16±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 水溶解度 :
- Insoluble in water
- 溶解性:
- DMSO:49.3(Max Conc. mg/mL);106.34(Max Conc. mM)
- 酸解離定数(Pka):
- 4.40±0.10(Predicted)
- 外見 :
- powder to crystal
- 色:
- White to Light yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
B5392 |
ビラスチン >98.0%(HPLC)(T)
Bilastine
>98.0%(HPLC)(T) |
202189-78-4 |
250mg |
￥27200 |
2024-03-01 |
購入 |
|
東京化成工業
|
B5392 |
ビラスチン >98.0%(HPLC)(T)
Bilastine
>98.0%(HPLC)(T) |
202189-78-4 |
1g |
￥81400 |
2024-03-01 |
購入 |
ビラスチン 化学特性,用途語,生産方法
外観
白色～うすい黄色粉末～結晶
効能
抗アレルギー薬, 鎮痒薬, H1受容体拮抗薬
商品名
ビラノア (大鵬薬品工業); ビラノア (大鵬薬品工業)
説明
Bilastine, a potent and selective histamine H1 receptor antagonist, was
approved in Europe in 2010 for the treatment of allergic rhinoconjunctivitis
(AR) and urticaria (hives or skin rash). The original synthesis of bilastine involves alkylation of 2-piperidinyl-1H-benzimidazole with a phenethyltosylate,
the para position of which is substituted with a dimethyloxazoline
moiety serving as a masked carboxylic acid group. Alkylation of the
benzimidazole nitrogen with 2-chloroethyl ethyl ether followed by
unmasking of the oxazoline moiety with sulfuric acid provided bilastine.
In two major clinical trials, bilastine was effective
at relieving allergic rhinitis as assessed by measuring the severity of nasal (obstruction, rhinorrhea, itching, sneezing) and nonnasal (ocular
itching, tearing, ocular redness, itching of ears, and/or palate) symptoms.
使用
Bilastine is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
臨床応用
Bilastine is a selective histamine H1 antagonist approved for the
treatment of allergic rhinoconjunctivitis and urticaria (hives). This drug, which has proven to be well tolerated in toxicology profiling,
46 was discovered by the Spainsh firm FAES Farma and was
approved by the European Union in 2010.
ビラスチン 上流と下流の製品情報
原材料
準備製品
ビラスチン 生産企業
Global( 257)Suppliers
202189-78-4(ビラスチン)キーワード:
- 202189-78-4
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-α,α-diMethylbenzeneacetic Acid
- Benzeneacetic acid,4-[2-[4-[1-(2-ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-a,a-diMethyl-
- BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL-
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzoimidazol-2-yl]-1-piperidyl]ethyl]phenyl]-2-methyl-propanoic acid
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-alpha,alpha-dimethylbenzeneacetic acid
- Bilasten
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid
- the impurity of Bilastine
- 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid
- 2-[4-[2-[4-[1-(2-Ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylproionic acid
- Bilatex
- Benzeneacetic acid, 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-α,α-dimethyl-
- BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL- USP/EP/BP
- 2-[4-[2-[4-[1-(2-Ethoxyethyl)benzimidazol-2-yl]piperidin-1-y...
- 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-3-methylpropanoic acid
- BilastineQ: What is
Bilastine Q: What is the CAS Number of
Bilastine Q: What is the storage condition of
Bilastine Q: What are the applications of
Bilastine
- Bilastine D6Q: What is
Bilastine D6 Q: What is the CAS Number of
Bilastine D6 Q: What is the storage condition of
Bilastine D6 Q: What are the applications of
Bilastine D6
- Bilastine
- Bilastin
- Bilaxten
- 2-(4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZO[D ]IMIDAZOL-2-YL) PIPERIDIN-1-YL)ETHY)PHEN YL)-2-METHYLPROPANOIC ACID
- Bilastine (Form-I)
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoicaci
- Bilastine In-House
- Bilastene
- ビラスチン
- ビラスチン (JAN)
- 2-[4-[2-[4-[1-(2-エトキシエチル)-1H-ベンゾイミダゾール-2-イル]ピペリジン-1-イル]エチル]フェニル]-2-メチルプロパン酸
- 2-[4-(2-{4-[1-(2-エトキシエチル)-1H-1,3-ベンゾジアゾール-2-イル]ピペリジン-1-イル}エチル)フェニル]-2-メチルプロパン酸
- ビラノア