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アニレリジン

アニレリジン 化学構造式
144-14-9
CAS番号.
144-14-9
化学名:
アニレリジン
别名:
英語化学名:
Anileridine
英語别名:
Adopol;Apidol;Alidine;Adopol-d4;Ethyl 1-(4;anileridine base;LKYQLAWMNBFNJT-UHFFFAOYSA-N;1-(p-AMinophenethyl)-4-phenylisonipecotic Acid Ethyl Ester;1-(p-AMinophenethyl)-4-phenylisonipecotic Acid-d4 Ethyl Ester;1-(p-AMinophenethyl)-4-phenylpiperidine-4-carboxylic Acid Ethyl Ester
CBNumber:
CB81178032
化学式:
C22H28N2O2
分子量:
352.47
MOL File:
144-14-9.mol

アニレリジン 物理性質

融点 :
83°C
沸点 :
486.07°C (rough estimate)
比重(密度) :
1.1096 (rough estimate)
屈折率 :
1.6500 (estimate)
外見 :
Solid
酸解離定数(Pka):
8.41±0.10(Predicted)

安全性情報

RIDADR  1544
国連危険物分類  6.1(b)
容器等級  III
毒性 LD50 orl-rat: 175 mg/kg 27ZIAQ -,-,65

アニレリジン 価格

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アニレリジン 化学特性,用途語,生産方法

効能

麻薬性鎮痛薬, オピオイド受容体作動薬

Originator

Leritine HCl,Merck Sharp and Dohme,US,1958

使用

A synthetic analgesic drug. 4-phenylpiperidine derivative that is an analog of Meperidine (M223900) with increased analgesic activity.

定義

ChEBI: A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl) thyl group.

Manufacturing Process

A mixture of 7.8 grams (0.05 mol) of β-(p-aminophenyl)ethyl chloride hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of anhydrous ethanol are mixed, stirred and heated under reflux for a period of approximately 40 hours and then concentrated in vacuum to dryness. The residual material is triturated with 50 cc of water, decanted, washed by decantation with an additional 50 cc of water, and then dried in vacuum to give N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine.
The N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine is dissolved in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic hydrochloric acid solution is added; upon scratching the side of the container crystals form. One hundred cubic centimeters of ether are then added to the mixture, the ethereal mixture is cooled, and the crystalline material which precipitates is recovered by filtration, washed with ether, and dried to give 12.7 grams of N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine dihydrochloride which can be further purified by recrystallization from ethanol or methanal to give substantially pure material; MP 275-277°C.

brand name

Leritine (Merck).

Therapeutic Function

Narcotic analgesic

安全性プロファイル

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.When heated to decomposition it emits toxic fumes ofNOx.

アニレリジン 上流と下流の製品情報

原材料

準備製品


アニレリジン 生産企業

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144-14-9(アニレリジン)キーワード:


  • 144-14-9
  • anileridine base
  • 1-(p-AMinophenethyl)-4-phenylisonipecotic Acid Ethyl Ester
  • 1-(p-AMinophenethyl)-4-phenylpiperidine-4-carboxylic Acid Ethyl Ester
  • 1-[2-(4-AMinophenyl)ethyl]-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester
  • Adopol
  • Alidine
  • Apidol
  • Ethyl 1-(4
  • 1-(p-AMinophenethyl)-4-phenyl(piperidine-d4)-4-carboxylic Acid Ethyl Ester
  • 1-(p-AMinophenethyl)-4-phenylisonipecotic Acid-d4 Ethyl Ester
  • 1-[2-(4-AMinophenyl)ethyl]-4-phenyl-4-(piperidinec-d4)arboxylic Acid Ethyl Ester
  • Adopol-d4
  • LKYQLAWMNBFNJT-UHFFFAOYSA-N
  • 4-Piperidinecarboxylic acid, 1-[2-(4-aminophenyl)ethyl]-4-phenyl-, ethyl ester
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