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ゲフィチニブ

ゲフィチニブ 化学構造式
184475-35-2
CAS番号.
184475-35-2
化学名:
ゲフィチニブ
别名:
ゲフィチニブ;イレッサ
英語化学名:
Gefitinib
英語别名:
IRESSA;ZD 1839;Gefinitib;GEFITINIB;Ji Fei Ji;Getfitnib;Gifitinib;AKOS 91371;Gefitinib WS;Gefitinib, >=99%
CBNumber:
CB8120056
分子式:
C22H24ClFN4O3
分子量:
446.9
MOL File:
184475-35-2.mol

ゲフィチニブ 物理性質

融点 :
119-1200C
貯蔵温度 :
Store at RT
外見 :
powder
色:
white to beige
CAS データベース:
184475-35-2(CAS DataBase Reference)

安全性情報

Sフレーズ  24/25

ゲフィチニブ 価格 もっと(8)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3000 イレッサ
Iressa
184475-35-2 10mg ¥50000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TOC3000 イレッサ
Iressa
184475-35-2 50mg ¥209000 2018-12-26 購入
東京化成工業 G0546 ゲフィチニブ >98.0%(HPLC)(T)
Gefitinib >98.0%(HPLC)(T)
184475-35-2 1g ¥7000 2018-12-04 購入
東京化成工業 G0546 ゲフィチニブ >98.0%(HPLC)(T)
Gefitinib >98.0%(HPLC)(T)
184475-35-2 5g ¥24000 2018-12-04 購入
Sigma-Aldrich Japan SML1657 ≥98% (HPLC)
Gefitinib ≥98% (HPLC)
184475-35-2 10mg ¥17300 2018-12-25 購入

ゲフィチニブ 化学特性,用途語,生産方法

外観

白色~わずかにうすい褐色、結晶性粉末~粉末

溶解性

ジメチルスルホキシド溶状:試験適合ジメチルスルホキシドに溶け、アセトン、エタノール及び水に難溶である。

用途

EGFR チロシンキナーゼ阻害 剤です。特に変異型 EGFR に対してより低濃 度で阻害活性を示します。

化学的特性

Light-Yellow Crystalline Powder

使用

Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

使用

Gefitinib is an antineoplastic.

適応症

The EGFR or ErbB1 inhibitor gefitinib (Iressa(R), AstraZeneca) was originally approved by the US FDA in 2003 under accelerated regulations for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after progression on docetaxel- and platinum-based chemotherapy. AstraZeneca voluntarily withdrew gefitinib from the market in 2005, owing to failed verification of clinical benefit during post-approval studies. In July 2015, FDA reinstated the approval of gefitinib for a different group of patients (i.e., NSCLC patients with EGFR mutations).
Other approved kinase inhibitors targeting the ErbB family, which includes ErbB1/EGFR, ErbB2/human epidermal growth factor receptor 2 (Her2), ErbB3/ Her3, and ErbB4/Her4, are erlotinib (Tarceva(R), OSI Pharm.), lapatinib (Tykerb(R), GlaxoSmithKline), vandetanib (Caprelsa(R), AstraZeneca), afatinib (Gilotrif(R), Boehringer Ingelheim) , and osimertinib (Tagrisso(R), AstraZeneca). All approved EGFR family inhibitors share a common quinazoline scaffold with the exception of osimertinib, which has a pyrimidinylphenylamine scaffold that resembles that of imatinib and nilotinib. Gefitinib and vandetanib adopt the type I binding mode with “DFG-in” and αC-helix “in” conformation, while erlotinib and lapatinib bind to“DFG-in”with the αC-helix adopting an “out” conformation. Afatinib and osimertinib are covalent inhibitors with an electrophilic enone moiety.

brand name

Iressa (AstraZeneca).

生物活性

Orally active, selective inhibitor of EGFR tyrosine kinase (IC 50 = 23-79 nM). Shows minimal activity against ErbB2, KDR, c-flt, PKC, MEK and ERK-2. Blocks EGFR autophosphorylation and inhibits tumor growth in mice bearing a range of human xenografts.

ゲフィチニブ 上流と下流の製品情報

原材料

準備製品


ゲフィチニブ 生産企業

Global( 397)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Frapp's ChemicalNFTZ Co., Ltd.
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+86 (576) 8169-6105 sales@frappschem.com China 887 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
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+86-371-55531817
info@dakenchem.com CHINA 22049 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
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Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60

184475-35-2(ゲフィチニブ)キーワード:


  • 184475-35-2
  • Gefitinib N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
  • IRESSA
  • GEFITINIB
  • AKOS 91371
  • n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
  • N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
  • Gefitinib(TINIBS)
  • 6-(Benzyloxy)-7-methoxyquinazolin-4(3H)-one
  • Gefinitib
  • ZD 1839
  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
  • Ji Fei Ji
  • Gefitinib Tablets
  • 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-(3-morpholinopropoxy)quinazoline
  • (3-chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl]amine
  • N-(4-bromo-2-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
  • Gefitinib, Iressa, ZD1839
  • Getfitnib
  • N-(3-Chloro-4-fluorophenyl)-7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-aMine
  • Gifitinib
  • Gefitinib (ZD1839)
  • Gefitinib WS
  • N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Gefitinib
  • Gefitinib, >=99%
  • N-(3-Chlor-4-fluorophenyl)-7-[methoxy-6-[(3-morpholin-4-yl)propoxyl]-quinazolin-4-yl]amine
  • GEFITINIB RELATED COMPOUND
  • ゲフィチニブ
  • イレッサ
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