パニツムマブ(遺伝子組換え)

パニツムマブ(遺伝子組換え) 化学構造式
339177-26-3
CAS番号.
339177-26-3
化学名:
パニツムマブ(遺伝子組換え)
别名:
パニツムマブ(遺伝子組換え);パニツムマブ
英語名:
Panitumumab
英語别名:
Abenix;Abx-egf;Vectibix;Panitumumab;Abx-egf mab;Unii-6A901E312a;Panitumumab USP/EP/BP;Research Grade Panitumumab(DHB86903);Research Grade Pintumomab (DHJ57401);Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer
CBNumber:
CB81216039
化学式:
分子量:
0
MOL File:
Mol file

パニツムマブ(遺伝子組換え) 物理性質

貯蔵温度 :
Store at -20°C

安全性情報

パニツムマブ(遺伝子組換え) 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

パニツムマブ(遺伝子組換え) 化学特性,用途語,生産方法

説明

Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody that is highly selective for the epidermal growth factor receptor (EGFR), and it is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression of EGFR is detected in many human cancers, including those of the colon and rectum. Panitumumab blocks the binding of ligands such as epidermal growth factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing cell lines, which results in inhibition of EGF-dependent tumor cell activation, induction of apoptosis, and decreased pro-inflammatory cytokine and vascular growth factor production. In vitro, panitumumab binds EGFR with high affinity (KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431. .

使用

Antineoplastic.

パニツムマブ(遺伝子組換え) 上流と下流の製品情報

原材料

準備製品


パニツムマブ(遺伝子組換え) 生産企業

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LGM Pharma 1-(800)-881-8210
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339177-26-3(パニツムマブ(遺伝子組換え))キーワード:


  • 339177-26-3
  • Panitumumab
  • Abx-egf
  • Abx-egf mab
  • Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer
  • Unii-6A901E312a
  • Vectibix
  • Abenix
  • Panitumumab USP/EP/BP
  • Research Grade Pintumomab (DHJ57401)
  • Research Grade Panitumumab(DHB86903)
  • パニツムマブ(遺伝子組換え)
  • パニツムマブ
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