ChemicalBook
Chinese english Germany Korea

酢酸アビラテロン

酢酸アビラテロン 化学構造式
154229-18-2
CAS番号.
154229-18-2
化学名:
酢酸アビラテロン
别名:
酢酸アビラテロン;3β-17-(3-ピリジル)アンドロスタ-5,16-ジエン-3-オールアセタート;アビラテロンアセタート;アビラテロン酢酸エステル;アビラテロン酢酸エステル (JAN);アビラテロンAcotate
英語化学名:
Abiraterone acetate
英語别名:
ZYTIGA;CS-212;CB 7630;Abirteroneacetate;ABITATERONE ACETATE;Abiraterone Acetate;Abiraterone Acotate;Abiraterone Acetate >Abiraterone Impurity 81;Abiraterone acetate 99.5%
CBNumber:
CB81396153
化学式:
C26H33NO2
分子量:
391.55
MOL File:
154229-18-2.mol

酢酸アビラテロン 物理性質

融点 :
127-130°C
沸点 :
506.7±50.0 °C(Predicted)
比重(密度) :
1.14±0.1 g/cm3(Predicted)
貯蔵温度 :
-20°C
酸解離定数(Pka):
5.31±0.12(Predicted)
外見 :
powder
色:
white to beige
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
WGK Germany  3
RTECS 番号 BV7992100
HSコード  2937290000
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H360 生殖能または胎児への悪影響のおそれ 生殖毒性 1A, 1B 危険
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。

酢酸アビラテロン 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01FLC213789 酢酸アビラテロン
Abiraterone acetate
154229-18-2 250mg ¥44400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC213789 酢酸アビラテロン
Abiraterone acetate
154229-18-2 1g ¥81300 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01FLC213789
Abiraterone acetate
154229-18-2 5g ¥320000 2021-03-23 購入
東京化成工業 A2891 酢酸アビラテロン >98.0%(HPLC)(T)
Abiraterone Acetate >98.0%(HPLC)(T)
154229-18-2 1g ¥45300 2021-03-23 購入
東京化成工業 A2891 酢酸アビラテロン >98.0%(HPLC)(T)
Abiraterone Acetate >98.0%(HPLC)(T)
154229-18-2 200mg ¥15100 2021-03-23 購入

酢酸アビラテロン 化学特性,用途語,生産方法

外観

白色~うすい黄色~うすい黄赤色粉末~結晶

効能

抗悪性腫瘍薬, アンドロゲン合成阻害薬

商品名

ザイティガ (ヤンセンファーマ)

説明

In April 2011, the United States FDA approved abiraterone acetate (CB7630) in combination with the steroid prednisone for the treatment of metastatic castration-resistant prostate cancer (mCRPC) for patients who were previously treated with a docetaxel containing regimen for late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting both the lyase and hydroxylase activity of cytochrome P450 17A (CYP17) signaling pathways (IC50's of 2.9 and 4 nM, respectively) thereby decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).

化学的特性

Off-White Solid

Originator

Institute of Cancer Research, London (United Kingdom)

使用

Abiraterone acetate was approved by the U.S. Food and Drug Administration (FDA) in April 2011 for the treatment of castrationresistant prostate cancer. The drug, marketed under the trade name Zytiga, was originally discovered by researchers at the Cancer Research UK Centre for Cancer Therapeutics in 1990, developed by Cougar Biotechnology, and ultimately commercialized by Johnson & Johnson after its acquisition of Cougar in 2009. Abiraterone acetate inhibits CYP17A1—an enzyme expressed in testicular, adrenal, and prostatic tumor tissues—which has been implied in the production of testosterone and the proliferation of such tumor cell lines.

使用

Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

使用

A novel steroidal inhibitor of human Cytochrome P450(17a-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.

定義

ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance .

brand name

Zytiga

Chemical Synthesis

The most convenient synthesis for scale-up will be highlighted from two published syntheses. Commercially available androstenolone 1 was acylated with acetic anhydride in the presence of boron trifluoride-diethyl etherate to give a near quantitative yield of acetate 2. The conversion of ketone 2 to vinyl triflate 3 involved careful selection of base to prevent elimination of the acetate group. To this extent, subjection of 2 to triflic anhydride in dichloromethane at ambient temperature followed by slow addition of triethylamine minimized undesired side products and delivered triflate 3 in 60% isolated yield. Subsequent Suzuki coupling with diethylborane 4 under standard conditions ultimately furnished abiraterone acetate (I) in 75% yield.

酢酸アビラテロン 上流と下流の製品情報

原材料

準備製品


酢酸アビラテロン 生産企業

Global( 360)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Joyochem Co.,Ltd
+8613290333633 +86-0531-82687558
0531-82687996 sales@joyochem.com;sales@jychem.cc China 28 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58

154229-18-2(酢酸アビラテロン)キーワード:


  • 154229-18-2
  • Abiraterone Acotate
  • Abiraterone Acetate impurity
  • (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
  • [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
  • (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate
  • Abiraterone acetate, >=99%
  • Abirteroneacetate
  • ZYTIGA
  • ABITATERONE ACETATE
  • 2-((3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodec
  • 17-(3-pyridyl)-5,16-androstadien-3beta-acetate
  • (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester)
  • Abiraterone Acetate
  • CB 7630
  • Abiraterone acetate 99.5%
  • Abiraterone acetate(CB7630)
  • 3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene
  • (3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester)
  • 2-((3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetate
  • Abiraterone acetate ester
  • Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-
  • Abiraterone acetate - CB 7630 | JNJ 212082
  • CS-212
  • Androsta-5,16-dien-3-ol,17-(3-pyridinyl)
  • 3-Epi-abiraterone Acetate stereoisomer
  • Abiraterone Acetate >
  • 17-(3-pyridyl)-5,16-androstadien-3beta-acetatee
  • 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
  • Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
  • Abiraterone Impurity 81
  • 酢酸アビラテロン
  • 3β-17-(3-ピリジル)アンドロスタ-5,16-ジエン-3-オールアセタート
  • アビラテロンアセタート
  • アビラテロン酢酸エステル
  • アビラテロン酢酸エステル (JAN)
  • アビラテロンAcotate
Copyright 2017 © ChemicalBook. All rights reserved