(R)-(-)-1,2-プロパンジオール 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
溶解性
水、エタノール及びジエチルエーテルと任意の割合で混和する。
用途
光学活性物質合成原料。
化学的特性
Colorless to light yellow liqui
使用
R-(-)-1,2-Propanediol, is a chiral building blocks that can be used for variety of chemical synthesis.
調製方法
Propylene is converted to chlorohydrin by chlorine water and
hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2-
propylene oxide is converted to propylene glycol.
応用例（製薬）
Propylene glycol has become widely used as a solvent, extractant,
and preservative in a variety of parenteral and nonparenteral
pharmaceutical formulations. It is a better general solvent than
glycerin and dissolves a wide variety of materials, such as
corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A
and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is
similar to glycerin and only slightly less effective than ethanol.
Propylene glycol is commonly used as a plasticizer in aqueous
film-coating formulations.
Propylene glycol is also used in cosmetics and in the food
industry as a carrier for emulsifiers and as a vehicle for flavors in
preference to ethanol, since its lack of volatility provides a more
uniform flavor.
貯蔵
At cool temperatures, propylene glycol is stable in a well-closed
container, but at high temperatures, in the open, it tends to oxidize,
giving rise to products such as propionaldehyde, lactic acid, pyruvic
acid, and acetic acid. Propylene glycol is chemically stable when
mixed with ethanol (95%), glycerin, or water; aqueous solutions
may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed
container, protected from light, in a cool, dry place.
不和合性
Propylene glycol is incompatible with oxidizing reagents such as
potassium permanganate.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (dental
preparations; IM and IV injections; inhalations; ophthalmic, oral,
otic, percutaneous, rectal, topical, and vaginal preparations).
Included in nonparenteral and parenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
(R)-(-)-1,2-プロパンジオール 上流と下流の製品情報
原材料
準備製品