2'-O-(2-Methoxyethyl)-5-methyluridine
2'-O-(2-Methoxyethyl)-5-methyluridine 物理性質
- 融点 :
- 115.5-116.5 °C
- 比重(密度) :
- 1.41
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO（微量）、メタノール（微量）、水（微量、超音波処理）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 9.55±0.10(Predicted)
- 色:
- オフホワイト
- 安定性：:
- 吸湿性
- InChI:
- InChI=1S/C13H20N2O7/c1-7-5-15(13(19)14-11(7)18)12-10(21-4-3-20-2)9(17)8(6-16)22-12/h5,8-10,12,16-17H,3-4,6H2,1-2H3,(H,14,18,19)/t8-,9-,10-,12-/m1/s1
- InChIKey:
- NEVQCHBUJFYGQO-DNRKLUKYSA-N
- SMILES:
- OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H320 |
眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2B |
警告 |
|
P264, P305+P351+P338,P337+P313 |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P302+P352 |
皮膚に付着した場合：多量の水と石鹸で洗うこと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
2'-O-(2-Methoxyethyl)-5-methyluridine 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
2'-O-(2-Methoxyethyl)-5-methyluridine 化学特性,用途語,生産方法
使用
2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.
主な応用
2'-O-(2-Methoxyethyl)-5-methyluridine (2'-MOE-5-Methyluridine) is a uridine nucleoside that is a combination of amidite with 5-methyluridine. 2'-MOE-5-Methyluridine is an intermediate in the synthesis of oligonucleotides, which are synthesized from phosphoramidites. Its analog 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine is a potent compound used in research of RNA viruses, particularly hepatitis C virus and picornaviruses.
合成
2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.
2'-O-(2-Methoxyethyl)-5-methyluridine 上流と下流の製品情報
原材料
準備製品
2'-O-(2-Methoxyethyl)-5-methyluridine 生産企業
Global( 99)Suppliers
163759-49-7()キーワード:
- 163759-49-7
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- 5-Me-2'-O-MOE U
- Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl-
- 5-Me-2'-O-MOE Uridine
- 2'-O-(2-Methoxyethy)-5-methyluridine
- 2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97%
- 1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE
- 2'-O-MOE-5-Methyluridin
- 2'-O-MOE-Tr
- 2'-O-Methoxyethyl-thyminde
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- 2'-MOE-5-Me-Uridine
- 2’-MOE-5-Methyluridine
- 5-Me-2'-O-MOE-Ur
- MOE-mrU
- 2'-MOE-5-Me-rU
- 2'-O-Methoxyethyl-5-methyluridine
- 2'-O-MOE-5-Me-rU
- 2'-O-(2-Methoxyethyl)-5-methyluridine
- 2’-O-(2-Methoxyethy)-5-methyl uridine