シメプレビル

シメプレビル 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

シメプレビル 化学特性,用途語,生産方法

効能

抗ウイルス薬, プロテアーゼ阻害薬

説明

In September 2013, simeprevir (also known as TMC435) was approved in Japan (trade name Sovriad?) for the treatment of genotype 1 hepatitis C virus (HCV) infection in combination with pegylated interferon and ribavirin (PR). Simeprevir was approved for the same indication in November 2013 in the United States (trade name Olysio?) and Canada (trade name Galexos?). Simeprevir is the third HCV PI to receive approval and was discovered from an effort to optimize a novel series of cyclopentane-core macrocyclic HCV PIs. Unlike the earlier PIs, simeprevir does not rely on formation of a covalent intermediate to inhibit the enzyme, but instead gains binding affinity through a large P2 quinoline substituent that occupies an extended S2 subsite of HCV protease by induced fit. This pocket is not occupied by inhibitors such as telaprevir and boceprevir. Other key features of simeprevir are truncation of the P3 capping group (the N-methyl amide), use of an acylsulfonamide as an acid isostere, and incorporation of an isopropylthiazole group to give improved permeability. Simeprevir is a potent NS3/4A PI (Ki=0.36 nM), with antiviral activity in the HCV replicon assay (genotype 1b EC₅₀=7.8 nM; genotype 1a EC₅₀=28.4 nM). It is 25-fold less potent against HCV genotype 2, >1000 less potent for HCV genotype 3, but has 3-fold better potency for HCV genotype 4.

Originator

Tibotec and Medivir (Ireland and Sweden)

brand name

Sovriad

シメプレビル 上流と下流の製品情報

原材料

準備製品

シメプレビル 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58

923604-59-5(シメプレビル)キーワード:

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• 923604-59-5
• (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide
• TMC 435350
• SiMeprevir
• TMC435,TMC435350,TMC-435350
• (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13, 14,14a-tetradecahydro-2-[[7-
• siMeprevir/TMC435
• (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-Methoxy-8-Methyl-2-[4-(1-Methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-Methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1
• Simeprevir(TMC 435350)
• TMC435
• (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-7-methoxy-8-methyl-2-4-(1-methylethyl)-2-thiazolyl-4-quinolinyloxy-5-methyl-4,14-dioxocyclopentaccyclopropag1,6diazacyclotetradecine-12a(1H)-carboxami
• (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetrad
• JTZZSQYMACOLNN-JMSVMWJJSA-N
• (2R,3aR,11aS,12aR,14aR,Z)-N-(cyclopropylsulfonyl)-2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carb
• CS-954
• TMC435350 (Simeprevir)
• PubChem ID: 24873435
• Simeprevir-13C-d3
• Simeprevir (sodium salt)
• (2R,3aR,11aS,12aR,14aR,Z)-N-(cyclopropylsulfonyl)-2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,12a,13,14,14a-hexadecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a-carboxamide
• Cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, (2R,3aR,10Z,11aS,12aR,14aR)-
• Simeprevir (1.0mg/ml in DMSO)
• (1R,4R,6S,15R,17R)-N-(cyclopropanesulfonyl)-17-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.0,4,6]octadec-7-ene-4-carboxamide
• (2R,3aR,11aS,12aR,14aR,Z)-N-(Cyclopropylsulfonyl)-2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide
• シメプレビル
• シメプレビル (JAN)
• (1R,4S,6R,7Z,15R,17R)-N-(シクロプロピルスルホニル)-13-メチル-17-[2-(4-イソプロピル-2-チアゾリル)-7-メトキシ-8-メチル-4-キノリルオキシ]-2,14-ジオキソ-3,13-ジアザトリシクロ[13.3.0.04,6]オクタデカン-7-エン-4α-カルボアミド
• (1R,4S,6R,7Z,15R,17R)-N-(シクロプロパンスルホニル)-17-({7-メトキシ-8-メチル-2-[4-(プロパン-2-イル)-1,3-チアゾール-2-イル]キノリン-4-イル}オキシ)-13-メチル-2,14-ジオキソ-3,13-ジアザトリシクロ[13.3.0.04,6]オクタデカ-7-エン-4-カルボキサミド
• (1R,4R,6S,7Z,15R,17R)-N-(シクロプロパンスルホニル)-17-({7-メトキシ-8-メチル-2-[4-(プロパン-2-イル)-1,3-チアゾール-2-イル]キノリン-4-イル}オキシ)-13-メチル-2,14-ジオキソ-3,13-ジアザトリシクロ[13.3.0.04,6]オクタデカ-7-エン-4-カルボキサミド
• (2R,3aR,10Z,12S,13R,15aR)-N-(シクロプロピルスルホニル)-2-[[2-(4-イソプロピルチアゾール-2-イル)-7-メトキシ-8-メチル-4-キノリル]オキシ]-5-メチル-4,15-ジオキソ-2,3,3a,4,5,6,7,8,9,12,13,14,15,15a-テトラデカヒドロ-12,13-メタノ-5,14-ジアザ-1H-シクロペンタシクロテトラデセン-13-カルボアミド
• (1R,4R,6S,15R,17R)-N-(シクロプロパンスルホニル)-17-({7-メトキシ-8-メチル-2-[4-(プロパン-2-イル)-1,3-チアゾール-2-イル]キノリン-4-イル}オキシ)-13-メチル-2,14-ジオキソ-3,13-ジアザトリシクロ[13.3.0.04,6]オクタデカ-7-エン-4-カルボキサミド
• (1R,10S,12R,15R,17R)-3-メチル-12-[[(シクロプロピルスルホニル)アミノ]カルボニル]-17-[2-(4-イソプロピルチアゾール-2-イル)-8-メチル-7-メトキシキノリン-4-イルオキシ]-3,13-ジアザトリシクロ[13.3.0.010,12]オクタデカ-8-エン-2,14-ジオン