(1S-CIS)-ミルナシプラン塩酸塩
(1S-CIS)-ミルナシプラン塩酸塩 物理性質
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO:57.0(Max Conc. mg/mL);201.55(Max Conc. mM)
- 外見 :
- A crystalline solid
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
(1S-CIS)-ミルナシプラン塩酸塩 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQV-0092 |
(1S-Cis)-milnacipran hydrochloride |
175131-60-9 |
100mg |
￥52500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQV-0092 |
(1S-cis)-ミルナシプラン塩酸塩
(1S-Cis)-milnacipran hydrochloride |
175131-60-9 |
250mg |
￥105000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQV-0092 |
(1S-cis)-ミルナシプラン塩酸塩
(1S-Cis)-milnacipran hydrochloride |
175131-60-9 |
1g |
￥260000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQV-0092 |
(1S-Cis)-milnacipran hydrochloride |
175131-60-9 |
10g |
￥1157500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQV-0092 |
(1S-cis)-ミルナシプラン塩酸塩
(1S-Cis)-milnacipran hydrochloride |
175131-60-9 |
5g |
￥705000 |
2024-03-01 |
購入 |
(1S-CIS)-ミルナシプラン塩酸塩 化学特性,用途語,生産方法
効能
抗うつ薬, セロトニン・ノルアドレナリン再取り込み阻害薬
説明
Levomilnacipran (Fetzima®) is a dual serotonin–norepinephrine
reuptake inhibitor (SNRI) approved by the FDA in 2013 for the
treatment of major depressive disorders (MDD).
Levomilnacipran is the most active enantiomer of the racemate
Milnacipran, which is currently used to treat pain associated
with fibromyalgia. The drug was developed by Forest
Laboratories and the Pierre Fabre group.
使用
The S-enatiomer of Milnacipran (M344600).
合成
Reaction of phenylacetonitrile (100) and commercially available
(R)-epichlorohydrin (101) with NaNH2 led to chloride displacement
and intramolecular cyclopropanation, yielding lactone 102
after a one-pot nitrile hydrolysis and acid-promoted lactonization (75% yield over 3 steps). Lactone ring-opening with Et2NH¨CAlCl3
complex provided amido-alcohol 103, which was converted to its
phthalimido derivative 104 by sequential treatment with thionyl
chloride and potassium phthalimide in 80% over three steps.
Finally, levomilnacipran hydrochloride (XIII) was obtained in
>95% optical purity after phthalimide cleavage, HCl salt formation,
and crystallization from HCl/i-PrOH/i-PrAc. This sequence represents
a highly efficient route to levomilnacipran, requiring no isolation
of intermediates, resulting in >40% overall yield, and
allowing use of the same solvent solution (toluene) for all steps.
(1S-CIS)-ミルナシプラン塩酸塩 上流と下流の製品情報
原材料
準備製品
(1S-CIS)-ミルナシプラン塩酸塩 生産企業
Global( 129)Suppliers
175131-60-9((1S-CIS)-ミルナシプラン塩酸塩)キーワード:
- 175131-60-9
- (1S,2R)-2-(AMinoMethyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide Hydrochloride
- (1S-cis)-Milnacipran Hydrochloride
- LevoMilnacipran hydrochloride
- (1S,2R)-Milnacipran hydrochloride
- F 2695 hydrochloride
- Levomilnacipran HCl
- Milnacipran ((1S-cis) hydrochloride)
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- Milnacipran (1S-cis)
- L-Milnacipran HCl
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- Levomilnacipran HCl (F2695
- Levominaprine
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- Levomilnacipran HClQ: What is
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Levomilnacipran HCl
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- (1S-CIS)-ミルナシプラン塩酸塩
- レボミルナシプラン塩酸塩