UnifiraM
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- CAS番号.
- 272786-64-8
- 化学名:
- 别名:
- 英語名:
- UnifiraM
- 英語别名:
- UnifiraM;sunifiram
DM-232;2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro-;(8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one;2-[(4- fluorophenyl) sulfonyl] hexahydropyrrolo [1,2-A] pyrazine -6(2H)- one;2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
- CBNumber:
- CB82651143
- 化学式:
- C13H15FN2O3S
- 分子量:
- 298.3332032
- MOL File:
- 272786-64-8.mol
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UnifiraM 物理性質
- 沸点 :
- 479.5±55.0 °C(Predicted)
- 比重(密度) :
- 1.47±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
- 外見 :
- A solid
- 酸解離定数(Pka):
- -0.82±0.20(Predicted)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
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注意喚起語 |
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危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
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P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
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P264, P280, P305+P351+P338,P337+P313P |
H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露; 気道刺激性 |
3 |
警告 |
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注意書き |
P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
P264 |
取扱い後は皮膚をよく洗うこと。 |
P264 |
取扱い後は手や顔をよく洗うこと。 |
P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
P271 |
屋外または換気の良い場所でのみ使用すること。 |
P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
P301+P312 |
飲み込んだ場合:気分が悪い時は医師に連絡する こと。 |
P302+P352 |
皮膚に付着した場合:多量の水と石鹸で洗うこと。 |
P304+P340 |
吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
P321 |
特別な処置が必要である(このラベルの... を見よ)。 |
P330 |
口をすすぐこと。 |
P332+P313 |
皮膚刺激が生じた場合:医師の診断/手当てを受けるこ と。 |
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UnifiraM 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
UnifiraM 化学特性,用途語,生産方法
説明
Unifiram (DM-232) is structurally similar to Sunifiram, and is a highly potent AMPAkine-line compound with effective cognition-enhancing and anti-amnesiac effects in animal models. Although sometimes grouped with racetam compounds, Unifiram is technically not a racetam due to the broken pyrrolidone backbone.
Animal research has shown that Unifiram has a significantly greater Nootropic potency than Piracetam or Phenylpiracetam. Unifiram is shares structural similarities to Sunifiram. Animal models show similar modes of action for both compounds – increased cognitive performance and anti-amnesiac effects through interactions with the glutamatergic system and particularly through AMPA-receptor activation.
使用
Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam.
利点
Unifiram is believed to improve learning, memory, concentration, mental energy and basic cognition.
Mode of action
Although the Unifiram did not show any affinity for several important binding sites, it was found to prevent amnesia through modulation of various neurotransmitter systems and by increasing acetylcholine release in the cerebral cortex.
Unifiram's mechanism of action is known to be similar to that of Sunifiram. Sunifiram's mechanism of action is better defined than that of Unifiram, and we will briefly explain it here.
At a dosage range of 10-100nM, Sunifiram enhances NMDA-dependent signaling by increasing PKCα phosphorylation – dependent on glycine binding site availability and as an antagonist to glycine. The observable increase in AMPA receptor activation activity post-administration has been associated with increases in CAMKII and PKCα phosphorylation. Furthermore, the increased activity of AMPA receptor activation has been associated with increased CAMKII and PKCα phosphorylation.
UnifiraM 上流と下流の製品情報
原材料
準備製品
UnifiraM 生産企業
Global( 86)Suppliers
272786-64-8()キーワード:
- 272786-64-8
- 2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
- (8aR)-2-[(4-fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
- Pyrrolo[1,2-a]pyrazin-6(2H)-one, 2-[(4-fluorophenyl)sulfonyl]hexahydro-
- UnifiraM
- 2-(4-fluorophenyl)sulfonyl-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one
- sunifiram
DM-232
- 2-[(4- fluorophenyl) sulfonyl] hexahydropyrrolo [1,2-A] pyrazine -6(2H)- one