ダイレクト ブルー 14 化学特性,用途語,生産方法
外観
暗褐色～暗紫褐色, 結晶～粉末及び小塊
溶解性
水に溶ける。
解説
トリパンブルー，C34H24N6Na4O14S4(960.82)．タンパク質に強く結合するアゾ色素．青灰色の粉末．水に可溶，エタノールに不溶．0.01％ 程度の深青色の生理的塩類溶液で細胞を処理すると，膜に傷害のある細胞にはすみやかに侵入して染色するが，健全な細胞は染色しないので，細胞の生死を判定する色素排除試験に用いられる．血流に加えたとき，血清タンパク質との結合物が貪食作用によって細胞内に取り込まれて，青い顆粒を生じることから，尿細管上皮，そのほかの細胞の生体染色に用いられる．また，トリパノゾーマ症の治療に用いられた．
用途
染料
用途
トリパノゾーマ症の治療に用いられた。死細胞染色色素。細胞死の一般的な判定方法として古くから最も多く用いられているものがTrypan Blueを用いた分染法と呼ばれる一種の生体染色法である。
化学的特性
Trypan Blue is a dark Blue crystalline solid or powder that dissolves in water to form a blue solution. It's slightly soluble in soluble fiber yarn and doesn't dissolve in other organic solvents. When mixed with concentrated sulfuric acid, it turns dark greenish-blue, and when diluted, it becomes reddish-blue. With concentrated nitric acid, it creates a brownish-gray solution. In a 10% sulfuric acid solution, its aqueous solution turns red, while with sodium hydroxide, it becomes reddish-purple.
定義
ChEBI: Trypan blue is an organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid). It has a role as a histological dye, a fluorochrome and a carcinogenic agent. It is an organosulfonate salt and an organic sodium salt. It contains a trypan blue(4-).
製造方法
3,3′-Dimethylbenzidine double nitriding, in alkaline conditions and 4-Amino-5-hydroxynaphthalene-2,7-disulfonic acid(2 Moore) coupled.
一般的な説明
Bluish-gray to dark blue powder.
空気と水の反応
Azo dyes can be explosive when suspended in air at specific concentrations. Slightly soluble in water.
反応プロフィール
Direct Blue 14 is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Direct Blue 14 is incompatible with strong oxidizing agents and strong acids.
健康ハザード
ACUTE/CHRONIC HAZARDS: Direct Blue 14 may cause irritation and may be absorbed through the skin. It is a positive animal carcinogen. When heated to decomposition Direct Blue 14 emits very toxic fumes of nitrogen oxides, sulfur oxides, carbon monoxide and carbon dioxide.
火災危険
Flash point data for Direct Blue 14 are not available; however, Direct Blue 14 is probably combustible.
安全性プロファイル
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intraperitoneal, intravenous, and
subcutaneous routes. Experimental
teratogenic and reproductive effects.
Mutation data reported. When heated to
decomposition it emits very toxic fumes of
NOx NazO, and SOx
職業ばく露
Used in dyeing textiles; leather and
paper; as a biological stain.
輸送方法
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3143 dyes, solid, toxic, n.o.s. or dye
intermediates, solid, toxic, n.o.s., Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required.
不和合性
Dust may form explosive mixture with
air. Trypan Blue is incompatible with strong oxidizing
agents. Incompatible with oxidizers (chlorates, nitrates,
peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides. Azo compounds can detonate. This
applies in particular to organic azides that have been sensitized
by the addition of metal salts or strong acids. Toxic
gases are formed by mixing materials of this class with
acids, aldehydes, amides, carbamates, cyanides, inorganic
fluorides, halogenated organics, isocyanates, ketones,
metals, nitrides, peroxides, phenols, epoxides, acylhalides,
and strong oxidizing or reducing agents. Flammable gases
are formed by mixing materials in this group with alkali
metals. Explosive combinations can occur with strong oxidizing
agents, metal salts, peroxides, and sulfides. Trypan
Blue is sensitive to prolonged exposure to heat.
廃棄物の処理
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste
disposal.
ダイレクト ブルー 14 上流と下流の製品情報
原材料
準備製品