WIN 55,212-2メシル酸塩

WIN 55,212-2メシル酸塩 価格 もっと(10)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01CAY10009023	(+)-WIN 55,212-2 (mesylate)	131543-23-2	5mg	￥12900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CAY10009023	(+)-WIN 55,212-2 (mesylate)	131543-23-2	10mg	￥24600	2024-03-01	購入
Sigma-Aldrich Japan	W102	(R)-(+)-WIN 55,212-2 メシル酸塩 ≥98% (HPLC) (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC)	131543-23-2	25mg	￥99400	2024-03-01	購入
Sigma-Aldrich Japan	W102	(R)-(+)-WIN 55,212-2 メシル酸塩 ≥98% (HPLC) (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC)	131543-23-2	100mg	￥163000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01MAS090582	(R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)methanone methanesulfonate	131543-23-2	250mg	￥652300	2024-03-01	購入

WIN 55,212-2メシル酸塩 化学特性,用途語,生産方法

外観

白色〜黄褐色, 結晶〜粉末

溶解性

N,N-ジメチルホルムアミド溶状：試験適合

説明

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with K_i values of 62.3 and 3.3 nM for human recombinant CB₁ and CB₂ receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca²⁺ concentrations below 0.2 mM, or by the IP₃ receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC₅₀ value of 26 μM.

使用

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

一般的な説明

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

生物活性

Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

WIN 55,212-2メシル酸塩 上流と下流の製品情報

原材料

準備製品

WIN 55,212-2メシル酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Kangcang new material Technology Co., LTD	+8619133911216	Jany1001@kangcang.com.cn	China	338	58
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58

131543-23-2(WIN 55,212-2メシル酸塩)キーワード:

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• 131543-23-2
• R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI
• (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy
• 212-2Mesylate
• WIN55
• (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt
• (R)-(+)-WIN 55,212-2 mesylate salt
• WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt
• (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone
• (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone Methanesulfonate
• (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl
• WIN 55212-2 methanesulfonate
• (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1
• (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE
• R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE
• R(+)-WIN 55,212-2 MESYLATE
• WIN 55,212-2 MESYLATE
• WIN 55,212-2
• (+)-WIN 55,212-2 mesylate - CAS 131543-23-2 - Calbiochem
• CS-754
• WIN552122;WIN-552122
• WIN552122;WIN-552122;(R)-(+)-WIN 55212
• [(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone Monomethanesulfonate
• (R)-(+)-WIN 55,212-2 mesylate salt >=98% (HPLC)
• (R)-(+)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo1,2,3-de-1,4-benzoxazin-6-yl-1-naphthalenylmethan one mesylate
• WIN 55,212-2メシル酸塩
• WIN55,212-2メシル酸塩
• (R)-(+)-WIN 55,212-2 メシル酸塩
• WIN 55212-2メシル酸塩
• [(3R)-2,3-ジヒドロ-5-メチル-3-(モルホリノメチル)ピロロ[1,2,3-de]-1,4-ベンゾオキサジン-6-イル](1-ナフタレニル)メタノン・メタンスルホン酸
• WIN-55212-2メシラート