D-エリスロ-スフィンゴシン,N-アセチル- 化学特性,用途語,生産方法
外観
白色～ほとんど白色, 粉末又は顆粒
溶解性
クロロホルムに溶ける。
用途
情報伝達系の研究、有機合成原料(医薬、農薬、化粧品）。
説明
C2 ceramide is a cell-
permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-
60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. C2 ceramide also enhances the expression of COX-
2 in human dermal fibroblasts and stimulates the growth of bovine aortic smooth muscle cells. The ability of C2 ceramide to destabilize membranes may be responsible for its inhibition of platelet aggregation.
化学的特性
White Crystalline Solid
使用
A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2
生物活性
A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro .
D-エリスロ-スフィンゴシン,N-アセチル- 上流と下流の製品情報
原材料
準備製品