[LYS47]ヒルジン(HV2) ヒル由来
[LYS47]ヒルジン(HV2) ヒル由来 物理性質
- 貯蔵温度 :
- 2-8°C
- 外見 :
- 凍結乾燥粉末
- 色:
- 白い
- Merck :
- 13,4737
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| Sフレーズ |
22-24/25 |
|
|
| WGK Germany |
3 |
|
|
| RTECS 番号 |
MR8440000 |
|
|
| F |
10-21 |
|
|
| HSコード |
3504009000 |
|
|
| 絵表示（GHS） |
 
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H317 |
アレルギー性皮膚反応を起こすおそれ |
感作性、皮膚 |
1 |
警告 |
|
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ |
感作性、呼吸器 |
1 |
危険 |
|
P261, P285, P304+P341, P342+P311,P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
|
[LYS47]ヒルジン(HV2) ヒル由来 価格
もっと(6)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
H0393 |
ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
8001-27-2 |
100units |
￥96200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
H0393 |
ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
8001-27-2 |
500units |
￥335000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
94581 |
lyophilized powder, white, >1500?U/vial
Hirudin recombinant from yeast lyophilized powder, white, >1500?U/vial |
8001-27-2 |
1ea |
￥296000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
H0393 |
[Lys47]ヒルジン(HV2) ヒル由来
Hirudin
recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
8001-27-2 |
100un |
￥69800 |
2018-12-25 |
購入 |
|
Sigma-Aldrich Japan
|
H7380 |
ヒルジン ヒル由来 lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units)
Hirudin from leeches lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units) |
8001-27-2 |
100un |
￥34900 |
2018-12-25 |
購入 |
[LYS47]ヒルジン(HV2) ヒル由来 化学特性,用途語,生産方法
説明
Refludan was launched in Germany for heparin-associated
thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis),
the gene for recombinant hirudin was synthesized and expressed in Saccharomyces
cerevisiae. The isolated protein is 65 amino acids differing from the native protein by
the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain
the three disulfide bonds. Refludan is a potent, specific and almost irreversible
inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds
to the active catalytic site of thrombin, while the C-terminal end binds to the anion
binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it
can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ
as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is
a pure, single compound with a single mechanism of action. It is useful for myocardial
infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited
by platelets activated by the Fc fragment of antibodies developed to the antigen of
heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.
使用
Recombinant hirudin from yeast has been used in mannan-binding lectin serine protease 2 (MASP2) activation assay. It has also been used in pre-treating the nanosheets in phosphate buffered saline (PBS) for platelet adhesion assay.
一般的な説明
Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan, arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80°C.
[LYS47]ヒルジン(HV2) ヒル由来 上流と下流の製品情報
原材料
準備製品
[LYS47]ヒルジン(HV2) ヒル由来 生産企業
Global( 78)Suppliers
8001-27-2([LYS47]ヒルジン(HV2) ヒル由来)キーワード:
- 8001-27-2
- hirudex
- recombinanthirudin
- HIRUDIN RECOMBINANT
- DESULFATO-HIRUDIN
- DESULFO-HIRUDIN
- NATIVE HIRUDIN
- [TYR63]HIRUDIN (HV1), LEECH
- (63-tyrosine)hirudin (hv1),leech,rec. F. yeast
- [Tyr63]Hirudin (HV1), leech recombinant, from yeast
- hirudin from leeches
- Hirudin recombinant from yeast
- Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces Cere
- [63-tyrosine]hirudin (HV1), leech recombinant
- [63-TYROSINE]HIRUDIN (HV1), LEECH
- [63-Tyrosine]Hirudin (HV1), leech, Desulfato-hirudin, Desulfo-hirudin
- Hirudin, Hirudo medicinalis, Recombinant, Saccharomyces cerevisiae - CAS 8001-27-2 - Calbiochem
- [LYS47]ヒルジン(HV2) ヒル由来
- ヒルジン ヒル由来