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コバマミド

コバマミド 化学構造式
13870-90-1
CAS番号.
13870-90-1
化学名:
コバマミド
别名:
5'-デオキシー5'-アデノシル)コバラミド 補酵素;アデノシルコバラミンE(COENZYMコエンザイムB12;コエンザイムB12;コバマミド;コバミド補酵素;コバマミド (JAN)
英語化学名:
5'-Deoxyadenosylcobalamin
英語别名:
lm176;AdoCbl;COBAMIDE;calomide;COBAMAMIDE;funacomide;dbccoenzyme;dibencozide;COENZYME B12;DMBC COENZYME
CBNumber:
CB8433734
化学式:
C72H100CoN18O17P
分子量:
1579.58
MOL File:
13870-90-1.mol

コバマミド 物理性質

貯蔵温度 :
-20°C
酸解離定数(Pka):
3.5(at 25℃)
水溶解度 :
26g/L(24 ºC)
Merck :
13,2476
BRN :
4122932

安全性情報

主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  22-24/25-36-26
WGK Germany  3
RTECS 番号 GG3800000
8
HSコード  2936260000
毒性 LD50 oral in guinea pig: 5gm/kg

コバマミド 価格 もっと(12)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00001433 アデノシルコバラミンe(CoenzymコエンザイムB12
Adenosylcobalamine(Coenzyme B12)
13870-90-1 100mg ¥22500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00001433 アデノシルコバラミンe(CoenzymコエンザイムB12
Adenosylcobalamine(Coenzyme B12)
13870-90-1 25mg ¥12700 2021-03-23 購入
Sigma-Aldrich Japan C0884 コエンザイムB12 ≥97.0%
Coenzyme?B12 ≥97.0%
13870-90-1 100mg ¥25000 2021-03-23 購入
Sigma-Aldrich Japan C0884 コエンザイムB12 ≥97.0%
Coenzyme?B12 ≥97.0%
13870-90-1 25mg ¥12320 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00001433 アデノシルコバラミンe(CoenzymコエンザイムB12
Adenosylcobalamine(Coenzyme B12)
13870-90-1 1g ¥127700 2021-03-23 購入

コバマミド 化学特性,用途語,生産方法

効能

貧血治療薬, ビタミンB12補充薬

商品名

コバマミド (鶴原製薬); ハイコバール (エーザイ)

Originator

Actimide,Tobishi

使用

emulsifying agent

定義

ChEBI: A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.

Manufacturing Process

Isopropylidine adenosine was converted to the p-toluene sulphonyl (tosyl) ester by reaction with tosyl chlorine solution, following the method of Clark et al. (1951) [J. Chem. Soc. 2952]. Because of its tendency to cyclization, the reagent was used directly it was ready. A reaction flask with separating funnels was set up in such a way that the whole system could be evacuated and filled with pure nitrogen two or three times, to eliminate all oxygen, and reagents could then be added when desired, in the closed system.
The flask contained 700.0 mg hydroxocobalamin in 20 ml of water, one funnel 200.0 mg sodium borohydride in 10 ml of water, and another the crude isopropylidine adenosine tosyl ester made from 500 mg isopropylidine adenosine dissolved in 10 ml of 50% aqueous methanol. On adding the borohydride to the vitamin, the color changed instantly from red to brown, then slowly to a greenish black. After 15 min the isopropylidine adenosine tosyl ester was added, and the colour slowly changed to a red-brown. After 45 min at room temperature air was admitted and the mixture was shaken to reoxidise any remaining reduced vitamin B12. The alkaline solution was neutralized with dilute hydrochloric acid and extracted with phenol carbon tetrachloride 3:1 in small portions till the aqueous layer was nearly colorless. The combined extracts were washed with water, mixed with about ten parts of carbon tetrachloride-acetone 10:1 and shaken with small portions of water till all red color was removed.
The product was purified by chromatography on columns of DEAE (diethyl aminoethyl) cellulose (3 x 1) followed by CM (carboxymethyl) cellulose (6 x 1), developed with water. Nearly all the color washed quickly through DEAE cellulose. The effluent and washes were applied to the CM cellulose column, which was further developed with water. Elution was continued as long as this fraction continued to emerge, in a total of 850 ml. One half of this fraction (425 ml) was concentrated to a few ml under reduced pressure; it crystallized slowly after adding acetone to slight turbidity. So cobamamide was obtained.

Therapeutic Function

Anabolic, Analgesic

农业用途

Cobamide enzyme is the cobalt complex formed between the cobalt-porphyrin ring structure and the nucleotide in vitamin B12 co-enzyme.

コバマミド 上流と下流の製品情報

原材料

準備製品


コバマミド 生産企業

Global( 165)Suppliers
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Creative Enzymes
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13870-90-1(コバマミド)キーワード:


  • 13870-90-1
  • DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME, 5,6-
  • DMBC COENZYME
  • COENZYME B12
  • COBAMAMIDE
  • COBAMAMIDE/DIBENCOZIDE
  • COBAMIDE
  • 5'-deoxyadenosylcobalamin
  • 5'-DEOXYADENOSYLCOBALAMINE
  • ADENOSYL COBALAMINE
  • 5,6-DIMETHYLBENZIMIDAZOLYLCOBAMIDE COENZYME
  • ster),innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidaz
  • coenzyme B12 crystalline
  • Cobamamide/VitaminB12
  • Coenzyme B12
  • ADENOSYLCOBALAMINE(COENZYME B12)(RG)
  • COBAMAMIDE (PYROGEN FREE)
  • 5μ-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
  • cobalaminecoenzyme
  • cobinamide,o-(5’-deoxyadenosine-5’)deriv.,hydroxide,dihydrogenphosphate(e
  • dbccoenzyme
  • deoxyadenosylcobalamin
  • dibencozide
  • funacomide
  • lm176
  • ADENOSYLCOBALAMINE(COENZYME B12)(P)
  • Coenzyme B12,5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme
  • ADENOSYLCOBALAMINE(COENZYME B12)(AS)
  • CobinaMide,Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3) (9CI)
  • Cobamamide (Dibencozide, Coenzyme B12)
  • COENZYME B12, >=97.0%
  • 5'-デオキシー5'-アデノシル)コバラミド 補酵素
  • アデノシルコバラミンE(COENZYMコエンザイムB12
  • コエンザイムB12
  • コバマミド
  • コバミド補酵素
  • コバマミド (JAN)
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