(3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド

(3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド 価格 もっと(4)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC5960	TMI 1	287403-39-8	10mg	￥93000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC5960	TMI 1	287403-39-8	50mg	￥392000	2024-03-01	購入
Sigma-Aldrich Japan	PZ0336	≥98% (HPLC) TMI-1 ≥98% (HPLC)	287403-39-8	5mg	￥22400	2024-03-01	購入
Sigma-Aldrich Japan	PZ0336	≥98% (HPLC) TMI-1 ≥98% (HPLC)	287403-39-8	25mg	￥72000	2024-03-01	購入

(3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド 化学特性,用途語,生産方法

説明

TMI 1 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17/TACE; IC₅₀ = 8.4 nM in a cell-free enzyme assay). It inhibits matrix metalloproteinase-1 (MMP-1), -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC₅₀s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively). It also inhibits ADAM8, -10, -12, and -17/TACE in cell-free enzyme assays with K_i values of 21, 16, 1.8, and 0.079 nM, respectively, with slow-binding inhibition of ADAM17/TACE but not the other ADAM enzymes. TMI 1 inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC₅₀s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC₅₀s = 190 and 300 nM, respectively). It inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis with IC₅₀ values of less than 100 nM without inhibiting TNF-α expression in vitro. TMI 1 inhibits LPS-induced TNF-α production in mice (ED₅₀ = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis. It also decreases cell viability of (ED₅₀s = 1.3-8.1 μM), and induces caspase-3/7 activity in, a variety of cancer cell lines and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer when administered at a dose of 100 mg/kg.

使用

TMI 1 is a dual TACE/MMP inhibitor, which represents a unique class of orally bioavailable small molecule TNF inhibitors that may be effective and beneficial for treating rhuematoid arthritis.

(3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド 上流と下流の製品情報

原材料

準備製品

(3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Nantong Hi-Future Biotechnology Co., Ltd	18051384581	sales@chemhifuture.com	China	2996	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

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• 287403-39-8
• TMI 1
• (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
• 3-Thiomorpholinecarboxamide, 4-[[4-(2-butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-, (3S)-
• TMI-1 >=98% (HPLC)
• TMI 1,TMI1
• (3S)-N-ヒドロキシ-2,2-ジメチル-4-[4-(2-ブチニルオキシ)フェニルスルホニル]チオモルホリン-3-カルボアミド
• (3S)-4-[4-(ブタ-2-イン-1-イルオキシ)ベンゼンスルホニル]-N-ヒドロキシ-2,2-ジメチルチオモルホリン-3-カルボキサミド