酢酸ヒストレリン
酢酸ヒストレリン 物理性質
- 比旋光度 :
- D20 -33.9° (c = 1 in acetic acid)
- 比重(密度) :
- 1.46±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
- 外見 :
- 粉
- 酸解離定数(Pka):
- 9.82±0.15(Predicted)
- 安定性：:
- Hygroscopic
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H360 |
生殖能または胎児への悪影響のおそれ |
生殖毒性 |
1A, 1B |
危険 |
|
|
|
| 注意書き |
| P201 |
使用前に取扱説明書を入手すること。 |
| P308+P313 |
暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。 |
|
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
L2761 |
[des-Gly10, D-His(Bzl)6]-LH-RHエチルアミド ≥97% (HPLC), powder
[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder |
76712-82-8 |
0.5mg |
￥21900 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
L2761 |
[des-Gly10, D-His(Bzl)6]-LH-RHエチルアミド ≥97% (HPLC), powder
[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder |
76712-82-8 |
1mg |
￥37700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
L2761 |
[des-Gly10, D-His(Bzl)6]-LH-RHエチルアミド ≥97% (HPLC), powder
[des-Gly10, D-His(Bzl)6]-LH-RH ethylamide ≥97% (HPLC), powder |
76712-82-8 |
.5mg |
￥28700 |
2018-12-25 |
購入 |
酢酸ヒストレリン 化学特性,用途語,生産方法
効能
抗悪性腫瘍薬, 性腺刺激ホルモン放出ホルモン受容体作動薬
説明
Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced
as a first-line therapy for the treatment of central precocious puberty. When administered over
a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular
steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with
progestational agents, histrelin appears to have decelerating effects on skeletal maturation
allowing more statural growth and significantly increased final adult height. Histrelin has also
been used to treat other disorders including endometriosis, polycystic ovarian disease,
uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent
porphyria.
使用
LHRH agonist.
定義
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro
in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.
酢酸ヒストレリン 上流と下流の製品情報
原材料
準備製品
酢酸ヒストレリン 生産企業
Global( 144)Suppliers
76712-82-8(酢酸ヒストレリン)キーワード:
- 76712-82-8
- Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
- 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
- RWJ-17070
- Supprelin
- 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
- Histreline Acetate
- ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
- (n-ethyl-l-prolinamide)-10-deglycinamide-
- 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
- orf17070
- PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
- PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET
- (HIS(BZL)6)-HISTRELIN
- HISTRELIN
- (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
- (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
- (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
- (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
- DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
- (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
- (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
- [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
- (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
- (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
- [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
- Histrelin USP/EP/BP
- Histrelin Acetate(net)
- 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
- PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
- histrelin acetate
- 5-オキソ-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-ベンジル-D-His-L-Leu-L-Arg-L-Pro-N-エチル-NH2
- ヒストレリン
- [DES-GLY10, D-HIS(BZL)6]-LH-RHエチルアミド
- 酢酸ヒストレリン
- (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(1-ベンジル-1H-イミダゾール-4-イル)-2-[(2S)-2-[(2S)-3-ヒドロキシ-2-[(2S)-2-[(2S)-3-(1H-イミダゾール-4-イル)-2-{[(2S)-5-オキソピロリジン-2-イル]ホルムアミド}プロパンアミド]-3-(1H-インドール-3-イル)プロパンアミド]プロパンアミド]-3-(4-ヒドロキシフェニル)プロパンアミド]プロパンアミド]-4-メチルペンタンアミド]-5-カルバムイミドアミドペンタノイル]-N-エチルピロリジン-2-カルボキサミド