N,N-ビス(トリメチルシリル)ホルムアミド
N,N-ビス(トリメチルシリル)ホルムアミド 物理性質
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| Rフレーズ |
10 |
|
|
| RIDADR |
UN 1993 3/PG 3 |
|
|
| WGK Germany |
3 |
|
|
| F |
10-21 |
|
|
| 国連危険物分類 |
3.2 |
|
|
| 容器等級 |
III |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
|
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H226 |
引火性の液体および蒸気 |
引火性液体 |
3 |
警告 |
|
|
|
| 注意書き |
|
N,N-ビス(トリメチルシリル)ホルムアミド 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
N,N-ビス(トリメチルシリル)ホルムアミド 化学特性,用途語,生産方法
物理的性質
81–82 °C/20 mmHg; 154 °C/760 mmHg;
mp 16–17 °C; n20
D 1.4388.
使用
N,N-Bis(trimethylsilyl)formamide can be used as source of nucleophilic formamide and N-silylaldimine synthon.
N,N-Bis(trimethylsilyl)formamide (BSF) exists in the amide form with both silyl groups attached to the nitrogen atom. This is in contrast to most other bis(TMS)amides (e.g., bis(TMS)- acetamide), which favor the N,O-bis(TMS)imidate isomer. BSF behaves as an N-formamido nucleophile, reacting with the carbonyl group of aldehydes and activated ketones to give N-formyl-O-trimethylsilyl-N,O-acetals. Similarly, reaction with imines (or their precursors) can in some cases give N-formylN,N-acetals. BSF undergoes reactions with a range of other electrophiles including acid chlorides, chloroformate esters, and isocyanates to give a range of interesting products. When treated with organolithium nucleophiles, attack occurs at the carbonyl function, to provide N-silylaldimines after elimination of a silyloxy unit. Such imines are reported to undergo further reactions to give heterocycles. There are also reports of BSF acting as a silylating agent, to give silyl enol ethers, although it is not commonly used for this application.
製造方法
chlorotrimethylsilane was added at room
temperature to a solution of formamide and triethylamine in
dry benzene and the mixture was heated at reflux for 1 h. The
reaction mixture was filtered, and the filtrate was evaporated to
give a crude oil. This was purified by high-vacuum distillation
to afford N,N-bis(trimethylsilyl)formamide (BSF) as an oil in
75% yield.
N,N-ビス(トリメチルシリル)ホルムアミド 上流と下流の製品情報
原材料
準備製品
N,N-ビス(トリメチルシリル)ホルムアミド 生産企業
Global( 38)Suppliers
15500-60-4(N,N-ビス(トリメチルシリル)ホルムアミド)キーワード:
- 15500-60-4
- n,n-bis(trimethylsilyl)-formamid
- N,N-BIS(TRIMETHYLSILYL)FORMAMIDE
- BSF
- BIS-N N-(TRIMETHYLSILYL)FORMAMIDE
- N,N-Bis-(trimethylsilyl)-formamide(BSF)
- BIS-N N-(TRIMETHYLSILYL)FORMAMIDE 97%
- Formamide, N,N-bis(trimethylsilyl)-
- N,N-ビス(トリメチルシリル)ホルムアミド