ChemicalBook
Chinese english Germany Korea

サリチル酸メチル

サリチル酸メチル 化学構造式
119-36-8
CAS番号.
119-36-8
化学名:
サリチル酸メチル
别名:
サリチル酸メチル;アナルギット;メチルサリシラート;アントラポールND;ティーベリーオイル;冬緑油;ウィンターグリーン油;ウインターグリーン油;o-ヒドロキシ安息香酸メチル;フルカルミット;ウインターグリーンオイル;エキサギエン;ベツラオイル;ベツロール;2-ヒドロキシベンゼンカルボン酸メチル;メチルサリシレート;2-ヒドロキシ安息香酸メチル;スウィートバーチオイル;o-ヒドロキシ安息香酸メチル(サリチル酸メチル);メチル=2-ヒドロキシベンゾアート
英語化学名:
Methyl salicylate
英語别名:
Linsal;Betula;analgit;exagien;NSC 8204;FEMA 2745;FEMA 2154;Flucarmit;PredaLure;BETULA OIL
CBNumber:
CB8491046
化学式:
C8H8O3
分子量:
152.15
MOL File:
119-36-8.mol

サリチル酸メチル 物理性質

融点 :
-8 °C
沸点 :
222 °C(lit.)
比重(密度) :
1.174 g/mL at 25 °C(lit.)
蒸気密度:
5.26 (vs air)
蒸気圧:
1 mm Hg ( 54 °C)
屈折率 :
n20/D 1.536(lit.)
FEMA :
2745 | METHYL SALICYLATE
闪点 :
226 °F
溶解性:
Very slightly soluble in water, miscible with ethanol (96 per cent) and with fatty and essential oils.
酸解離定数(Pka):
pKa 9.90 (Uncertain)
外見 :
Liquid
色:
Clear colorless to pale yellow
水溶解度 :
0.07 g/100 mL (20 ºC)
Merck :
14,6120
JECFA Number:
899
BRN :
971516
安定性::
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey:
OSWPMRLSEDHDFF-UHFFFAOYSA-N
CAS データベース:
119-36-8(CAS DataBase Reference)
NISTの化学物質情報:
2-Hydroxybenzoic acid methyl ester(119-36-8)
EPAの化学物質情報:
Benzoic acid, 2-hydroxy-, methyl ester(119-36-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22-36/38-36/37/38
Sフレーズ  26-36-24/25
RIDADR  3082
WGK Germany  1
RTECS 番号 VO4725000
8
自然発火温度 847 °F
TSCA  Yes
国連危険物分類  6.1(b)
容器等級  III
HSコード  29182300
有毒物質データの 119-36-8(Hazardous Substances Data)
毒性 LD50 orally in rats: 887 mg/kg (Jenner)
消防法 危険物第4類第三石油類(非水溶性)
化審法 (3)-1585
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

サリチル酸メチル 価格 もっと(40)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01W0113-0306 サリチル酸メチル 98.0+% (Capillary GC)
Methyl Salicylate 98.0+% (Capillary GC)
119-36-8 25mL ¥1600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01W0113-0306 サリチル酸メチル 98.0+% (Capillary GC)
Methyl Salicylate 98.0+% (Capillary GC)
119-36-8 500mL ¥4100 2018-12-26 購入
東京化成工業 S0015 サリチル酸メチル >99.0%(GC)
Methyl Salicylate >99.0%(GC)
119-36-8 25g ¥1600 2018-12-04 購入
東京化成工業 S0015 サリチル酸メチル >99.0%(GC)
Methyl Salicylate >99.0%(GC)
119-36-8 500g ¥3600 2018-12-04 購入
関東化学株式会社(KANTO) 25343-00 サリチル酸メチル >99.0%(GC)
Methyl salicylate >99.0%(GC)
119-36-8 500g ¥3900 2018-12-13 購入

サリチル酸メチル MSDS


Birch-Me

サリチル酸メチル 化学特性,用途語,生産方法

外観

無色~わずかにうすい黄色, 澄明の液体

定義

本品は、サリチル酸(*)のメチルエステルであり、次の化学式で表される。
参照表示名称:サリチル酸

溶解性

エタノール及びアセトンに極めて溶けやすく、水に溶けにくい。

用途

香料、医薬品原料

用途

サリチル酸にメチル基が付加 された化合物です。プロスタグランジン生合 成阻害作用を示します。

用途

サリチル酸にメチル基が付加 された化合物です。プロスタグランジン生合 成阻害作用を示します。

化粧品の成分用途

変性剤、口腔衛生剤、外用鎮痛剤、香料、香味剤

効能

鎮痛薬, 抗炎症薬

商品名

サリチル酸メチル (東豊薬品)

説明

Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester that is naturally produced by many species of plants. Some of the plants which produce it are called wintergreens, hence the common name. This compound is used as a fragrance. It is also found in liniments (rubbing ointments).

化学的特性

Methyl Salicylate is the main component of wintergreen oil and occurs in small quantities in other essential oils and fruits. It is a colorless liquid with a sweet, phenolic odor.

化学的特性

colourless liquid with an odour of wintergreen

化学的特性

Methyl salicylate has a characteristic wintergreen-like odor. May be prepared by extraction from natural sources; or by esterification of salicylic acid with methanol.

化学的特性

Methyl salicylate has a minty, spicy, sweet, wintergreen-like odor.

化学的特性

Wintergreen is an evergreen shrub with slender, creeping stems, assurgent, flowering branches with toothed leaves clustered at the top, white, bell-shaped flowers blossoming July to August, followed by red berries (checkerberries). The plant grows extensively in the woods of Canada and the United States (Pennsylvania). The leaves are harvested between June and September. Wintergreen has an aromatic odor and flavor similar to methyl salicylate.

天然物の起源

Numerous plants produce methyl salicylate in very small amounts. Some plants, such as the following, produce more:
Some species of the genus Gaultheria in the family Ericaceae, including Gaultheria procumbens, the wintergreen or eastern teaberry;
Some species of the genus Betula in the family Betulaceae, particularly those in the subgenus Betulenta such as B. lenta, the black birch;
All species of the genus Spiraea in the family Rosaceae, also called the meadowsweets.
This compound is produced most likely as an anti-herbivore defense. If the plant is infected with herbivorous insects, the release of methyl salicylate may function as an aid in the recruitment of beneficial insects to kill the herbivorous insects.Aside from its toxicity, methyl salicylate may also be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus.

使用

Methyl salicylate occurs in the leaves ofGaultheria procumbens L. and in the barkof Betulaceae. It is produced by esterificationof salicylic acid with methanol. It is used inperfumery and as a flavoring agent.

使用

In high concentrations as a rubefacient in deep heating liniments (such as Bengay) to treat joint and muscular pain. Randomised double blind trial reviews report evidence of its effectiveness that is weak, but stronger for acute pain than chronic pain, and that effectiveness may be due entirely to counter-irritation. However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID.
In low concentrations as a flavoring agent (no more than 0.04%; it is toxic).
providing fragrance to various products and as an odor-masking agent for some organophosphate pesticides. If used excessively, it can cause stomach and kidney problems.
Attracting male orchid bees, who apparently gather the chemical to synthesize pheromones; it is commonly used as bait to attract and collect these bees for study.
Clear plant or animal tissue samples of color, and as such is useful for microscopy and immunohistochemistry when excess pigments obscure structures or block light in the tissue being examined. This clearing generally only takes a few minutes, but the tissue must first be dehydrated in alcohol.
A mint flavoring in some kinds of chewing gum and candy, as an alternative to the more common peppermint and spearmint oils. It can also be found as a flavoring of root beer. It is also a potentially entertaining source of tri boluminescence ; when mixed with sugar and dried, it gains the tendency to build up electrical charge when crushed or rubbed. This effect can be observed by crushing wintergreen Life Savers candy in a dark room.

使用

Methyl salicylate is used in high concentrations as a rubefacient in deep heating liniments (such as Bengay) to treat joint and muscular pain. Randomised double blind trial reviews report evidence of its effectiveness that is weak, but stronger for acute pain than chronic pain, and that effectiveness may be due entirely to counter-irritation. However, in the body it metabolizes into salicylates, including salicylic acid, a known NSAID.
It is used in low concentrations as a flavoring agent (no more than 0.04 %; it is toxic). It is also used to provide fragrance to various products and as an odor-masking agent for some organophosphate pesticides . If used excessively, it can cause stomach and kidney problems.
Methyl salicylate is among the compounds that attract male orchid bees, who apparently gather the chemical to synthesize pheromones; it is commonly used as bait to attract and collect these bees for study.

使用

In perfumery; for flavoring candies, etc.

使用

antipyretic analgesics

使用

Methyl salicylate is an organic ester that is commonly produced naturally by wintergreens. Methyl salicylate is utilize as a anti-herbivore defense system in various plants that produces it. Methyl sa licylate is also used in high concentrations as a rubefacient to treat joint, muscular pain and acute pain. Methyl slicylate is also used as a flavoring agent and often used to provide fragrance to pr oducts.

使用

Potent inhibitor of ornithine decarboxylase

定義

ChEBI: A benzoate ester that is the methyl ester of salicylic acid.

調製方法

Methyl acetate, a novel acyl acceptor for biodiesel production has been developed, and a comparative study on Novozym 435-catalyzed transesterification of soybean oil for biodiesel production with different acyl acceptors has been studied (Noureddini et al., 2005).

Figure 1 shows the effect of the molar ratio of methanol to sunflower oil on the methyl ester yield for catalytic (3% CaO) transesterification in supercritical methanol at 523 K.

製造方法

Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or winter green).

Composition

The leaves of wintergreen are reported to contain arbutin, caffeic acid, ericolin, ferulic acid, gaultherase, gaultheric acid, gaultherin, gentisinc acid, methyl salicylate (5445 to 7920 ppm) o-pyrocatachuic acid, p-coumaric acid, p-hydroxybenzoic acid, primverose, protocatachuic acid, syringic acid, tannic acid, tannin, tricontane and vallininc acid.

Aroma threshold values

Detection: 40 ppb

Taste threshold values

Taste characteristics at 10 ppm: sweet, salicylate and root beer with aromatic and balsamic nuances

一般的な説明

Colorless yellowish or reddish liquid with odor of wintergreen.

空気と水の反応

Insoluble in water.

反応プロフィール

Methyl Salicylate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Birch-Me is incompatible with oxidizers. Birch-Me is also incompatible with strong bases. Birch-Me may react with iron salts.

危険性

Toxic by ingestion; use in foods restrictedby FDA, lethal dose 30 cc in adults, 10 cc in chil-dren.

健康ハザード

Methyl salicylate is a highly toxic compound.The toxic symptoms in humans include nausea, vomiting, gastritis, diarrhea, respiratorystimulation, labored breathing, pulmonaryedema, convulsions, and coma. Ingestion of15 to 25 mL of this compound may befatal to humans. Application of the liquidon the skin and eyes produced severe irrita tion in rabbits. Oral, subcutaneous, or der mal administration of methyl salicylate intest animals produced specific developmen tal abnormalities affecting the eyes, ears, andcentral nervous system
Toxicity of this compound is relativelymore severe in humans than in many com mon laboratory animals. The oral LD50 values in test animals were within the range800–1300 mg/kg.

健康ハザード

Harmful if swallowed, inhaled, absorbed through skin. Vapor mist is irritating to the eyes, mucous membranes, upper respiratory tract and skin. Ingestion of relatively small amount causes severe poisoning and death. Causes nausea, vomiting, acidosis, pulmonary edema, pneumonia, convulsions and death.

火災危険

Methyl salicylate is combustible.

接触アレルゲン

This anti-inflammatory agent is found in a wide number of ointments and can induce allergic contact dermatitis.

安全性

In pure form, methyl salicylate is toxic, especially when taken internally. A single teaspoon (5ml) of methyl salicylate contains 7g of salicylate, which is equivalent to more than twenty- three 300 mg aspirin tablets. The lowest published lethal dose is 101 mg / kg body weight in adult humans , (or 7.07 grams for a 70 - kg adult). It has proven fatal to small children in doses as small as 4 ml.[6] A seventeen-year- old cross - country runner at Notre Dame Academy on Staten Island, died in April 2007, after her body absorbed methyl salicylate through excessive use of topical muscle-pain relief products.
Most instances of human toxicity due to methyl salicylate are a result of over-application of topical analgesics, especially involving children. Some people have intentionally ingested large amounts of oil of wintergreen. Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood, plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy.

安全性プロファイル

Human poison by ingestion. Moderately toxic to humans by an unspecified route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: flaccid paralysis without anesthesia, general anesthesia, dyspnea, nausea, vomiting, and respiratory stimulation. Experimental reproductive effects. A severe skin and eye irritant. Ingestion of relatively small amounts has caused severe poisoning and death. Combustible liquid when exposed to heat or flame; can react with oxibzing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Chemical Synthesis

By esterification from natural sources; by esterification of salicylic acid with methanol

純化方法

Dilute the ester with Et2O, wash with saturated NaHCO3 (it may effervesce due to the presence of free acid), brine, dry MgSO4, filter, evaporate and distil it. Its solubility is 1g/1.5L of H2O. The benzoyl derivative has m 92o (b 270-280o/120mm), and the 3,5-dinitrobenzoate has m 107.5o, and the 3,5-dinitrocarbamoyl derivative has m 180-181o. [Hallas J Chem Soc 5770 1965, Beilstein 10 IV 143.]

サリチル酸メチル 上流と下流の製品情報

原材料

準備製品


サリチル酸メチル 生産企業

Global( 406)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2909 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58

119-36-8(サリチル酸メチル)キーワード:


  • 119-36-8
  • SYNTHETIC OIL OF WINTERGREEN
  • SWEET BIRCH OIL
  • RARECHEM AL BF 0029
  • o-Hydroxybenzoic acid methyl ester
  • OIL OF WINTERGREEN
  • WINTERGREEN
  • WINTERGREEN OIL, SYNTHETIC
  • analgit
  • 2-HYDROXYBENZOIC ACID METHYL ESTER
  • 2-(methoxycarbonyl)phenol
  • 2-Carbomethoxyphenol
  • FEMA 2745
  • FEMA 2154
  • exagien
  • Flucarmit
  • Gaultheria oil
  • BETULA OIL
  • BIRCH OIL, SWEET
  • Linsal
  • METHYL 2-HYDROXYBENZOATE
  • METHYL HYDROXYBENZOATE
  • METHYLIS SALICYLAS
  • METHYL SALICYLATE
  • METHYL-O-HYDROXYBENZOATE
  • METHYL SALICYLATE BP/USP GRADE
  • THYL SALICYLATE
  • Methyl Salicylate 2-Hydroxybenzoic acid methyl ester Wintergreen oil
  • METHYL SALICYLATE NF FCC
  • METHYL SALICYLATE EXTRA PURE, DAB, PH. E UR., B. P., PH. FRANC.
  • 2-Hydroxybenzoic acid methyl
  • サリチル酸メチル
  • アナルギット
  • メチルサリシラート
  • アントラポールND
  • ティーベリーオイル
  • 冬緑油
  • ウィンターグリーン油
  • ウインターグリーン油
  • o-ヒドロキシ安息香酸メチル
  • フルカルミット
  • ウインターグリーンオイル
  • エキサギエン
  • ベツラオイル
  • ベツロール
  • 2-ヒドロキシベンゼンカルボン酸メチル
  • メチルサリシレート
  • 2-ヒドロキシ安息香酸メチル
  • スウィートバーチオイル
  • o-ヒドロキシ安息香酸メチル(サリチル酸メチル)
  • メチル=2-ヒドロキシベンゾアート
  • メチル=サリチラート
  • サリチル酸メチル (JP17)
  • 抗炎症薬成分
  • 生化学
  • 薬理研究用試薬
  • 非ステロイド系消炎薬
Copyright 2017 © ChemicalBook. All rights reserved