トカイニド塩酸塩 化学特性,用途語,生産方法
効能
抗不整脈薬, ナトリウムチャネル遮断薬
使用
Tonocard(AstraZeneca).
一般的な説明
Tocainide hydrochloride,2-amino-2＇ ,6 ＇-propionoxyxylidide hydrochloride (Tonocard)(pKa 7.7), is an analog of lidocaine. It is orally active and haselectrophysiological properties like those of lidocaine. Totalbody clearance of tocainide hydrochloride is only166 mL/min, suggesting that hepatic clearance is not large.Because of low hepatic clearance, the hepatic extraction ratiomust be small; therefore, tocainide hydrochloride is unlikelyto be subject to a substantial first-pass effect. The drug differsfrom lidocaine, in that it lacks two ethyl groups, which providestocainide hydrochloride some protection from first-passhepatic elimination after oral ingestion. Tocainide hydrochlorideis hydrolyzed in a manner similar to that of lidocaine.None of its metabolites is active.
臨床応用
Tocainide hydrochloride is classed as a IB antiarrhythmicagent and used orally to prevent or treat ventricular ectopyand tachycardia. The drug is given in 400- to 600-mgdoses every 8 hours.
トカイニド塩酸塩 上流と下流の製品情報
原材料
準備製品