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ポリミキシンB/硫酸

ポリミキシンB/硫酸 化学構造式
1405-20-5
CAS番号.
1405-20-5
化学名:
ポリミキシンB/硫酸
别名:
ポリミキシンB/硫酸;硫酸ポリミキシンB;ポリミキシンB硫酸塩;ポリミキシン-B2,5-硫酸塩標準品;バチルスセレウス選択サプリメント;バチルスセレウス選択寒天基礎培地;ポリミキシン‐B2,5‐硫酸塩標準品;ポリミキシンB硫酸塩, 細胞培養用;POLYMYXIN B 硫酸;ポリミキシンB 硫酸塩;ポリミキシンB 溶液;ポリミキシン B 硫酸塩;ポリミキシンB硫酸塩 (JP17)
英語化学名:
Polymyxin B sulfate
英語别名:
Poly-RX;APPLISORB;AEROSPORIN;MASTIMYXIN;POLYMYXIN B;MYP SUPPLEMENT;POLYMYXIN B (PMB);PolymyxineBsulfate;POLYMIXIN B SULFATE;POLYMYXIN B SULFATE
CBNumber:
CB8666707
化学式:
C56H100N16O17S
分子量:
1301.56
MOL File:
1405-20-5.mol

ポリミキシンB/硫酸 物理性質

融点 :
217-220°C (dec.)
貯蔵温度 :
2-8°C
溶解性:
H2O: 50 mg/mL
外見 :
powder
酸解離定数(Pka):
pKa 8.9 (Uncertain)
色:
colorless or slightly yellow
PH:
pH (10g/L, 25℃) : 4.5~7.0
光学活性 (optical activity):
[α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
水溶解度 :
Soluble in water at 50mg/ml/n
Merck :
14,7573
CAS データベース:
1405-20-5(CAS DataBase Reference)
EPAの化学物質情報:
Polymixin B sulfate (1405-20-5)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22
Sフレーズ  22-24/25
RIDADR  3249
WGK Germany  3
RTECS 番号 TR1150000
3-8-10
HSコード  2941 90 00
国連危険物分類  6.1(b)
容器等級  III
絵表示(GHS)
注意喚起語
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P330 口をすすぐこと。

ポリミキシンB/硫酸 価格 もっと(48)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQC-8583
Polymixin B sulphate
1405-20-5 1g ¥13400 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBQC-8583
Polymixin B sulphate
1405-20-5 5g ¥46100 2021-03-23 購入
東京化成工業 P1923 ポリミキシンB硫酸塩
Polymyxin B Sulfate
1405-20-5 1g ¥9800 2021-03-23 購入
東京化成工業 P1923 ポリミキシンB硫酸塩
Polymyxin B Sulfate
1405-20-5 5g ¥33900 2021-03-23 購入
関東化学株式会社(KANTO) 711617-5 バチルスセレウス選択寒天基礎培地
Bacillus cereus selective agar base
1405-20-5 500g ¥24000 2021-03-23 購入

ポリミキシンB/硫酸 化学特性,用途語,生産方法

外観

白色〜黄褐色, 粉末

溶解性

水に溶けやすく、エタノールに極めて溶けにくく、エーテルにほとんど溶けない。水に溶ける。

用途

ポリミキシン系抗菌剤です。 細菌細胞質膜の透過性を変化させることによ り、抗菌作用を示します。緑膿菌、肺炎桿菌 といったグラム陰性桿菌に対して、優れた抗 菌作用を示します。

用途

薬理研究用。

効能

抗生物質, 細胞膜機能阻害薬

商品名

硫酸ポリミキシンB (ファイザー); 硫酸ポリミキシンB (ファイザー); 硫酸ポリミキシンB (ファイザー)

説明

The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.

化学的特性

White Solid

使用

antibacterial

使用

Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixtu re of Polymyxin B1 and B2 sulfate. Biological potency (dry basis): >6000U/mg.

使用

Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.

適応症

Polymyxin B is one of a group of cyclic polypeptides elaborated by Bacillus polymyxa. The drug is a surface-active agent. It is thought to alter the lipoprotein membrane of bacteria so that it no longer functions as an effective barrier, thereby allowing the cell contents to escape. Polymyxin B is effective against Pseudomonas, E. coli, and other gram-negative bacteria except the Proteus and Serratia species. It has little effect on gram-positive organisms.

brand name

(GlaxoSmithKline); Poly-Rx (X Gen).

一般的な説明

Polymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, thename B. polymyxa is used to refer to all of the strains thatproduce the closely related polypeptides called polymyxins.Other organisms (e.g., see “Colistin” later) also producepolymyxins. Identified so far are polymyxins A, B1,B2, C, D1, D2, M, colistin A (polymyxin E1), colistin B(polymyxin E2), circulins A and B, and polypeptin. Theknown structures of this group and their properties havebeen reviewed by Vogler and Studer. Of these,polymyxin B as the sulfate usually is used in medicine because,when used systemically, it causes less kidney damagethan the others. Polymyxin B sulfate is a nearly odorless, white to buff powder. It is freely soluble in water and slightly soluble in alcohol.

Biochem/physiol Actions

Polymyxin B?is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant?Enterobacteriaceae.

臨床応用

Polymyxin B is produced by fermentation of Bacillus polymyxa. It is separated from a mixture of related cyclic peptides and is primarily active against Gram-negative microorganisms. It apparently binds to phosphate groups in bacterial cytoplasmic membranes and disrupts their integrity. It is used IM or IV as a sulfate salt to treat serious urinary tract infections, meningitis, and septicemia, primarily caused by Pseudomonas aeruginosa, but some other Gram-negative bacteria also will respond. Irrigation of the urinary bladder with solutions of polymyxin B sulfate is employed as well by some to reduce the incidence of infections subsequent to installation of indwelling catheters. Additionally, it is used ophthalmically to treat infections by P. aeruginosa. When given parenterally, the drug is neuro- and nephrotoxic and, therefore, is employed only after other drugs have failed.

ポリミキシンB/硫酸 上流と下流の製品情報

原材料

準備製品


ポリミキシンB/硫酸 生産企業

Global( 418)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Shenzhen Shengda Pharma Limited
+86-755-85269922
WeChat:shengdapharm sales@shengdapharm.com CHINA 309 58
NANJING SUNSHINE BIOTECH CO.,LTD
+86-25-86189929
+86-25-86189616 brian@sunshine-bio.com CHINA 143 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58

1405-20-5(ポリミキシンB/硫酸)キーワード:

N2-(6-メチル-1-オキソヘプチル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Thr-L-A2bu-L-A2bu-L-Thr-) ポリミキシンアシラーゼ PSEUDOMONASSP. (シュードモナス)由来 N2-(6-メチルオクタノイル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Thr-L-A2bu-L-A2bu-L-Thr-) N2-(6-メチルヘプタノイル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Leu-) N2-(6-メチル-1-オキソヘプチル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) N2-(6-メチルヘプタノイル-L-A2bu-L-Thr-D-Ser-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Thr-L-A2bu-L-A2bu-L-Thr-) N2-(6-メチルオクタノイル-L-A2bu-L-Thr-D-Ser-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Thr-L-A2bu-L-A2bu-L-Thr-) N2-(L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-) (-)-N2-[[(6S)-6-メチルオクタノイル]-L-A2bu-L-Thr-L-A2bu-]シクロ(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-) N2-(6-メチルオクタノイル-L-A2bu-L-Thr-D-Ser-)シクロ(L-A2bu*-L-A2bu-D-Phe-L-Thr-L-A2bu-L-A2bu-L-Thr-) (-)-N2-(6-メチルオクタノイル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Leu-) 亜鉛バシトラシン N2-(6-メチルオクタノイル-L-A2bu-L-Thr-L-A2bu-)シクロ(L-A2bu*-L-A2bu-D-Leu-L-Leu-L-A2bu-L-A2bu-L-Thr-) ベンジルラジカル イソシアン酸 ベンジル ニコチン酸 ベンジル コンドロイチン硫酸ナトリウム ポリミキシンB

  • 1405-20-5
  • POLYMYXIN B
  • POLYMYXIN-B 2,5-SULFATE
  • POLYMYXIN B SULFATE
  • POLYMYXIN B SULFATE, BACILLUS POLYMYXA
  • POLYMYXIN B SULFATE SALT
  • POLYMYXIN B SULPHATE
  • POLYMYXIN B (PMB)
  • POLYMIXIN B SULFATE
  • POLYMIXIN B SULPHATE
  • MYP SUPPLEMENT
  • AEROSPORIN
  • N-[3-AMino-1-[[1-[[3-aMino-1-[[6,9,18-tris(2-aMinoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-Methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbaMoyl]propyl]carbaMoyl]-2-hydroxy-propyl]carbaMoyl]pro
  • Listeria monocytogenes Selective Supplement I, Polymyxin B sulfate salt
  • Polymyxin B/Sulfuric acid
  • Listeria mono Selective Supplement I,Listeria monocytogenes Selective Supplement I, Polymyxin B sulfate salt
  • Polymyxin B Sulfate (200 mg)
  • Polymyxin B Sulfate (200 mg) (COLD SHIPMENT REQUIRED)
  • N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-15-(phenylmethyl)-1,4
  • MASTIMYXIN
  • LISTERIA MONOCYTOGENES SELECTIVE SUPPLEMENT I
  • LISTERIA MONO SELECTIVE SUPPLEMENT I
  • CEREUS SELECTIVE SUPPLEMENT
  • BACILLUS CEREUS SELECTIVE AGAR BASE
  • BACILLUS CEREUS SELECTIVE SUPPLEMENT
  • APPLISORB
  • Polymyxin B solution
  • polymyxin B standard solution
  • polymyxin B sulfate usp
  • B POLYMYXIN B-SULFATE USP
  • POLYMYXIN B SULFATE CELL CULTURE TESTED
  • ポリミキシンB/硫酸
  • 硫酸ポリミキシンB
  • ポリミキシンB硫酸塩
  • ポリミキシン-B2,5-硫酸塩標準品
  • バチルスセレウス選択サプリメント
  • バチルスセレウス選択寒天基礎培地
  • ポリミキシン‐B2,5‐硫酸塩標準品
  • ポリミキシンB硫酸塩, 細胞培養用
  • POLYMYXIN B 硫酸
  • ポリミキシンB 硫酸塩
  • ポリミキシンB 溶液
  • ポリミキシン B 硫酸塩
  • ポリミキシンB硫酸塩 (JP17)
  • ペプチド系抗生物質
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