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シクラミン酸ナトリウム

シクラミン酸ナトリウム 化学構造式
139-05-9
CAS番号.
139-05-9
化学名:
シクラミン酸ナトリウム
别名:
N-シクロヘキシルスルファミン酸 ナトリウム;N-シクロヘキシルスルファミン酸ナトリウム;シクロ;シクラム酸ナトリウム;N-シクロヘキシルアミド硫酸ナトリウム;シクロヘキシルスルファミン酸ナトリウム;シクラミン酸ナトリウム;チクロ;サイクラミン酸ナトリウム;ナトリウム=シクロヘキシルスルファミダト;シクラメート;N-シクロヘキサンスルファミン酸ナトリウム;サイクラミン酸ナトリウム標準品;シクロヘキシルアミド硫酸ナトリウム;ナトリウムシクラメート;ナトリウムシクラメート, 98%
英語化学名:
Sodium N-cyclohexylsulfamate
英語别名:
asugryn;ibiosuc;sucrum7;sugarin;sugaron;cyclamic;suessette;suestamin;CYCLAMATE;Acofarinas
CBNumber:
CB8713674
化学式:
C6H12NNaO3S
分子量:
201.22
MOL File:
139-05-9.mol

シクラミン酸ナトリウム 物理性質

融点 :
>300 °C (lit.)
貯蔵温度 :
room temp
溶解性:
200g/l
外見 :
Powder
色:
White
PH:
5.5-7.5 (100g/l, H2O, 20℃)
水溶解度 :
>=10 g/100 mL at 20 ºC
Merck :
14,2703
BRN :
4166868
InChIKey:
UDIPTWFVPPPURJ-UHFFFAOYSA-M
CAS データベース:
139-05-9(CAS DataBase Reference)
IARC:
3 (Vol. Sup 7, 73) 1999
EPAの化学物質情報:
Sodium cyclamate (139-05-9)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn
Rフレーズ  22
Sフレーズ  36/37-24/25
WGK Germany  3
RTECS 番号 GV7350000
TSCA  Yes
HSコード  29299000
化審法 (3)-2480
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P330 口をすすぐこと。
P501 内容物/容器を...に廃棄すること。

シクラミン酸ナトリウム 価格 もっと(23)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA18666 ナトリウムシクラメート, 98%
Sodium cyclamate, 98%
139-05-9 250g ¥8640 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01AFAA18666 ナトリウムシクラメート, 98%
Sodium cyclamate, 98%
139-05-9 1000g ¥20410 2021-03-23 購入
東京化成工業 C0487 N-シクロヘキシルスルファミン酸ナトリウム >98.0%(N)
Sodium N-Cyclohexylsulfamate >98.0%(N)
139-05-9 500g ¥9200 2021-03-23 購入
東京化成工業 C0487 N-シクロヘキシルスルファミン酸ナトリウム >98.0%(N)
Sodium N-Cyclohexylsulfamate >98.0%(N)
139-05-9 25g ¥1800 2021-03-23 購入
関東化学株式会社(KANTO) 37154-30 シクロヘキシルスルファミン酸ナトリウム >98.0%(T)
Sodium cyclohexylsulfamate >98.0%(T)
139-05-9 25g ¥2300 2021-03-23 購入

シクラミン酸ナトリウム MSDS


Sodium N-cyclohexylsulfamate

シクラミン酸ナトリウム 化学特性,用途語,生産方法

外観

白色〜ほとんど白色, 結晶〜結晶性粉末

溶解性

水に溶ける。水よく溶け、エタノールに難溶、クロロホルム、ベンゼン、エーテルに不溶。

用途

チクロ(サイクラミン酸ナトリウム)は、人工甘味料のひとつ。IUPAC名はN-シクロヘキシルスルファミン酸ナトリウム sodium N-cyclohexylsulfamate。甘さは砂糖の30倍から50倍といわれる。後味がわずかに苦い(特に高濃度の場合)が、サッカリンやアセスルファムカリウムほどではなく、それらの高甘味度甘味料に比べてすっきりした砂糖に近い甘味をもつ。

用途

人工甘味料

効能

甘味料 (無栄養素)

化学的特性

Sodium cyclamate occurs as white, odorless or almost odorless crystals, or as a crystalline powder with an intensely sweet taste.

化学的特性

White powder

来歴

Cyclamate was first synthesized in 1937. Like the other sweeteners, its sweet taste was accidentally discovered (U.S. Pat. 2,275,125 (Mar. 3, 1942), L. F. Andrieth and M. Sveda (to E. I. du Pont de Nemours & Co., Inc.). The FDA in 1958 classified sodium cyclamate as a GRAS sweetener. In 1969, a 2-year chronic toxicity study with a sodium cyclamate–sodium saccharin (10:1) mixture found bladder tumors in rats. The FDA took cyclamate off the GRAS list, banning it from foods and beverages, but permitting its sale in pharmacies. In 1970, after a congressional investigation, the FDA banned the use of cyclamate entirely. Abbott Laboratories, which has conducted additional toxicity and carcinogenicity studies with cyclamate, a 10:1 mixture of cyclamate–saccharin, and cyclohexylamine, claimed to be unable to confirm the 1969 findings. Abbott then filed a food additive petition for cyclamate in 1973, which was denied by the FDA in 1980. In 1982, the Calorie Control Council and Abbott Laboratories filed a second food additive petition containing the results of additional safety studies (The Calorie Control Council and Abbott Laboratories, Food Additive Petition for cyclamate 2A3672 (Sept. 22, 1982). That petition remains active.

使用

Cyclamate (cyclohexylsulfamic acid and its calcium and sodium salts) were discovered in the United States in 1937. They are 30 to 80 times as sweet as sucrose and were widely used until late 1969, when it was banned by the FDA because of questions on safety. It is not banned in Canada and the European Union.
Cyclamate is produced by reacting cyclohexylamine with sulfonating agents, followed by reactions with sodium or calcium hydroxides to produce cyclamates and free cyclohexylamine as follows.
Owing to their good stability, cyclamates are suitable for all applications of intense sweeteners without a significant interfering taste sensation, and are heat stable. The main application of cyclamates is in blends with saccharin in a 10:1 ratio by weight. The mixture is more than twice as sweet as either component alone, making them an important sweetener in countries approving the use of both sweeteners.

使用

Sweetening agent.

調製方法

Cyclamates are prepared by the sulfonation of cyclohexylamine in the presence of a base. Commercially, the sulfonation can involve sulfamic acid, a sulfate salt, or sulfur trioxide. Tertiary bases such as triethylamine or trimethylamine may be used as the condensing agent. The amine salts of cyclamate that are produced are converted to the sodium, calcium, potassium, or magnesium salt by treatment with the appropriate metal oxide.

brand name

Adocyl;Ampenoline balsamoco;Assugrin;Azucrona;Cyclarin;Glusac super;Ilgon;Sladicin;Sucaryl calcium;Sucaryl sodium;Sucrum 7.

世界保健機関(WHO)

Cyclamates, non-nutritive sweetening agents, have been used as additives in food and drugs since 1950. They have been demonstrated to have a carcinogenic potential at very high and long-sustained dosage in experimental animals. Some countries have consequently banned their use as food additives, whereas in others they remain available for this purpose. Most countries, however, continue to allow their use in small quantities in pharmaceutical preparations. (Reference: (WHODI) WHO Drug Information, 77.2, 12, 1977)

一般的な説明

Odorless or almost odorless white crystals or crystalline powder. Intensely sweet taste, even in dilute solution. pH (10% solution in water): 5.5-7.5. Used as a non-nutritive sweetener.

空気と水の反応

Water soluble.

反応プロフィール

Sodium N-cyclohexylsulfamate is incompatible with strong oxidizing agents, strong acids and strong bases. Also incompatible with nitrites in acid solution. Has only limited compatibility with potassium salts .

危険性

Some evidence of causing cancer in lab- oratory animals. Prohibited by FDA for food use. Questionable carcinogen.

火災危険

Flash point data for Sodium N-cyclohexylsulfamate are not available; however, Sodium N-cyclohexylsulfamate is probably combustible.

応用例(製薬)

Sodium cyclamate is used as an intense sweetening agent in pharmaceutical formulations, foods, beverages, and table-top sweeteners. In dilute solution, up to about 0.17% w/v, the sweetening power is approximately 30 times that of sucrose. However, at higher concentrations this is reduced and at a concentration of 0.5% w/v a bitter taste becomes noticeable. Sodium cyclamate enhances flavor systems and can be used to mask some unpleasant taste characteristics. In most applications, sodium cyclamate is used in combination with saccharin, often in a ratio of 10 : 1.

安全性プロファイル

Moderately toxic by intravenous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NazO, SOx, and NOx.

毒性学

Sodium cyclamate is an odorless powder. It is about 30 times as sweet as sucrose in dilute solution. The structure of sodium cyclamate is shown in Figure 10.10 Capillary transitional cell tumors were found in the urinary bladders of 8 out of 80 rats that received 2600 mg/kg body weight per day of a mixture of sodium cyclamate and sodium saccharin (10:1) for up to 105 weeks. When the test mixture was fed at dietary levels designed to furnish 500, 1120, and 2500 mg/ kg body weight to groups of 35 and 45 female rats, the only significant finding was the occurrence of papillar carcinomas in the bladders of 12 of 70 rats fed the maximum dietary level of the mixture (equivalent of about 25 g/kg body weight) for periods ranging from 78 to 105 weeks (except for one earlier death). In vivo conversion from sodium cyclamate to cyclohexylamine was observed particularly in the higher dosage group. Cyclohexylamine is very toxic (LD50 rat oral=157 mg/dg) compared to sodium cyclamate (LD50 oral=12g/kg).

安全性

There has been considerable controversy concerning the safety of cyclamate following the FDA decision in 1970 to ban its use in the USA. This decision resulted from a feeding study in rats that suggested that cyclamate could cause an unusual form of bladder cancer. However, that study has been criticized because it involved very high doses of cyclamate administered with saccharin, which has itself been the subject of controversy concerning its safety; see Saccharin. Although excreted almost entirely unchanged in the urine, a potentially harmful metabolite of sodium cyclamate, cyclohexylamine, has been detected in humans. In addition, there is evidence to suggest cyclamate is metabolized to cyclohexylamine by the microflora in the large intestine of some individuals (approximately 25% of the population with higher precedence in Japanese than Europeans or North Americans). Cyclohexylamine, following absorption, is metabolized to an extent of 1-2% to cyclohexanol and cyclohexane-1,2-diol. Established no-observedeffect level (NOEL) and acceptable daily intake (ADI) values are based on cyclohexylamine levels of high cyclamate converters.(6,7) Extensive long-term animal feeding studies and epidemiological studies in humans have failed to show any evidence that cyclamate is carcinogenic or mutagenic. As a result, sodium cyclamate is now accepted in many countries for use in foods and pharmaceutical formulations.
Few adverse reactions to cyclamate have been reported, although its use has been associated with instances of photosensitive dermatitis.
The WHO has set an estimated acceptable daily intake for sodium and calcium cyclamate, expressed as cyclamic acid, at up to 11 mg/kg body-weight. In Europe, a temporary acceptable daily intake for sodium and calcium cyclamate, expressed as cyclamic acid, has been set at up to 1.5 mg/kg body-weight.
LD50 (mouse, IP): 1.15 g/kg
LD50 (mouse, IV): 4.8 g/kg
LD50 (mouse, oral): 17 g/kg
LD50 (rat, IP): 1.35 g/kg
LD50 (rat, IV): 3.5 g/kg
LD50 (rat, oral): 15.25 g/kg

貯蔵

Sodium cyclamate is hydrolyzed by sulfuric acid and cyclohexylamine at a very slow rate that is proportional to the hydrogen ion concentration. Therefore, for all practical considerations, it can be regarded as stable. Solutions are also stable to heat, light, and air over a wide pH range.
Samples of tablets containing sodium cyclamate and saccharin have shown no loss in sweetening power following storage for up to 20 years.
The bulk material should be stored in a well-closed container in a cool, dry place.

規制状況(Regulatory Status)

The use of cyclamates as artificial sweetners in food, soft drinks, and artificial sweetening tablets was at one time prohibited in the UK and some other countries owing to concern about the metabolite cyclohexylamine. However, this is no longer the case, and cyclamates are now permitted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral powder, solutions, chewable tablets, and suspensions). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

シクラミン酸ナトリウム 上流と下流の製品情報

原材料

準備製品


シクラミン酸ナトリウム 生産企業

Global( 243)Suppliers
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139-05-9(シクラミン酸ナトリウム)キーワード:


  • 139-05-9
  • assurgrinfeinsuss
  • assurgrinvollsuss
  • asugryn
  • cyclamate,sodiumsalt
  • cyclamic
  • cyclohexanesulfamicacid,monosodiumsalt
  • cyclohexanesulphamicacid,monosodiumsalt
  • cyclohexyl-sulfamicacimonosodiumsalt
  • cyclohexylsulphamatesodium
  • cyclohexylsulphamicacid,monosodiumsalt
  • dulzor-etas
  • hachi-sugar
  • ibiosuc
  • natriumzyklamate
  • n-cyklohexylsulfamatsodny
  • sodiumcyclohexanesulphamate
  • sodiumcyclohexylamidosulphate
  • sodiumcyclohexylsulphamate
  • sodiumcyclohexylsulphamidate
  • sodiumsucaryl
  • sucarylsodium
  • sucrum7
  • suessette
  • suestamin
  • sugarin
  • sugaron
  • Sulfamicacid,cyclohexyl-,monosodiumsalt
  • N-Cyclohexanesulfamic Acid Sodium Salt N-Cyclohexylsulfamic Acid Sodium Salt Sodium N-Cyclohexanesulfamate
  • SodiuM N-cyclohexylsulfaMate >=99.0% (T)
  • SODIUM N-CYCLOHEXANESULFAMATE
  • N-シクロヘキシルスルファミン酸 ナトリウム
  • N-シクロヘキシルスルファミン酸ナトリウム
  • シクロ
  • シクラム酸ナトリウム
  • N-シクロヘキシルアミド硫酸ナトリウム
  • シクロヘキシルスルファミン酸ナトリウム
  • シクラミン酸ナトリウム
  • チクロ
  • サイクラミン酸ナトリウム
  • ナトリウム=シクロヘキシルスルファミダト
  • シクラメート
  • N-シクロヘキサンスルファミン酸ナトリウム
  • サイクラミン酸ナトリウム標準品
  • シクロヘキシルアミド硫酸ナトリウム
  • ナトリウムシクラメート
  • ナトリウムシクラメート, 98%
  • 人工甘味料
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